A simple and efficient approach for the synthesis of 2-aminated quinazoline derivatives via metal free oxidative annulation

Amit N. Pandya; Eric Villa; E. Jeffrey North

doi:10.1016/j.tetlet.2017.02.033

A simple and efficient approach for the synthesis of 2-aminated quinazoline derivatives via metal free oxidative annulation

Amit N. Pandya, Eric Villa, E. Jeffrey North

Research output: Contribution to journal › Article

3 Citations (Scopus)

Abstract

A simple and efficient approach for the synthesis of 2-aminoquinazoline derivatives in moderate to good yields. This reaction employs mild reaction conditions, is metal-free and utilizes readily available starting materials making it a more viable reaction for scale up synthesis and ligand diversity. Notably, this methodology allows for the synthesis of 2-aminoquinazolines using a free amine or cyclic amine enabling structural diversity and good atom economy.

Original language	English (US)
Pages (from-to)	1276-1279
Number of pages	4
Journal	Tetrahedron Letters
Volume	58
Issue number	13
DOIs	https://doi.org/10.1016/j.tetlet.2017.02.033
State	Published - Mar 29 2017

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Quinazolines

Amines

Metals

Derivatives

Ligands

Atoms

All Science Journal Classification (ASJC) codes

Biochemistry
Drug Discovery
Organic Chemistry

Cite this

Pandya, A. N., Villa, E., & North, E. J. (2017). A simple and efficient approach for the synthesis of 2-aminated quinazoline derivatives via metal free oxidative annulation. Tetrahedron Letters, 58(13), 1276-1279. https://doi.org/10.1016/j.tetlet.2017.02.033

A simple and efficient approach for the synthesis of 2-aminated quinazoline derivatives via metal free oxidative annulation. / Pandya, Amit N.; Villa, Eric ; North, E. Jeffrey.

In: Tetrahedron Letters, Vol. 58, No. 13, 29.03.2017, p. 1276-1279.

Research output: Contribution to journal › Article

Pandya, AN, Villa, E & North, EJ 2017, 'A simple and efficient approach for the synthesis of 2-aminated quinazoline derivatives via metal free oxidative annulation', Tetrahedron Letters, vol. 58, no. 13, pp. 1276-1279. https://doi.org/10.1016/j.tetlet.2017.02.033

Pandya AN, Villa E , North EJ. A simple and efficient approach for the synthesis of 2-aminated quinazoline derivatives via metal free oxidative annulation. Tetrahedron Letters. 2017 Mar 29;58(13):1276-1279. https://doi.org/10.1016/j.tetlet.2017.02.033

Pandya, Amit N. ; Villa, Eric ; North, E. Jeffrey. / A simple and efficient approach for the synthesis of 2-aminated quinazoline derivatives via metal free oxidative annulation. In: Tetrahedron Letters. 2017 ; Vol. 58, No. 13. pp. 1276-1279.

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10.1016/j.tetlet.2017.02.033