A simple and efficient approach for the synthesis of 2-aminated quinazoline derivatives via metal free oxidative annulation

Amit N. Pandya, Eric Villa, E. Jeffrey North

Research output: Contribution to journalArticle

4 Scopus citations


A simple and efficient approach for the synthesis of 2-aminoquinazoline derivatives in moderate to good yields. This reaction employs mild reaction conditions, is metal-free and utilizes readily available starting materials making it a more viable reaction for scale up synthesis and ligand diversity. Notably, this methodology allows for the synthesis of 2-aminoquinazolines using a free amine or cyclic amine enabling structural diversity and good atom economy.

Original languageEnglish (US)
Pages (from-to)1276-1279
Number of pages4
JournalTetrahedron Letters
Issue number13
StatePublished - Mar 29 2017


All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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