A simple and efficient approach for the synthesis of 2-aminated quinazoline derivatives via metal free oxidative annulation

Amit N. Pandya, Eric Villa, E. Jeffrey North

Research output: Contribution to journal › Article

4 Citations (Scopus)

Abstract

A simple and efficient approach for the synthesis of 2-aminoquinazoline derivatives in moderate to good yields. This reaction employs mild reaction conditions, is metal-free and utilizes readily available starting materials making it a more viable reaction for scale up synthesis and ligand diversity. Notably, this methodology allows for the synthesis of 2-aminoquinazolines using a free amine or cyclic amine enabling structural diversity and good atom economy.

Original languageEnglish (US)
Pages (from-to)1276-1279
Number of pages4
JournalTetrahedron Letters
Volume58
Issue number13
DOIs
StatePublished - Mar 29 2017

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Quinazolines
Amines
Metals
Derivatives
Ligands
Atoms

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Cite this

A simple and efficient approach for the synthesis of 2-aminated quinazoline derivatives via metal free oxidative annulation. / Pandya, Amit N.; Villa, Eric; North, E. Jeffrey.

In: Tetrahedron Letters, Vol. 58, No. 13, 29.03.2017, p. 1276-1279.

Research output: Contribution to journal › Article

Pandya, AN, Villa, E & North, EJ 2017, 'A simple and efficient approach for the synthesis of 2-aminated quinazoline derivatives via metal free oxidative annulation', Tetrahedron Letters, vol. 58, no. 13, pp. 1276-1279. https://doi.org/10.1016/j.tetlet.2017.02.033
Pandya AN, Villa E, North EJ. A simple and efficient approach for the synthesis of 2-aminated quinazoline derivatives via metal free oxidative annulation. Tetrahedron Letters. 2017 Mar 29;58(13):1276-1279. https://doi.org/10.1016/j.tetlet.2017.02.033
Pandya, Amit N. ; Villa, Eric ; North, E. Jeffrey. / A simple and efficient approach for the synthesis of 2-aminated quinazoline derivatives via metal free oxidative annulation. In: Tetrahedron Letters. 2017 ; Vol. 58, No. 13. pp. 1276-1279.
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