A standard numbering scheme for class C β-lactamases

Andrew R. Mack; Melissa D. Barnes; Magdalena A. Taracila; Andrea M. Hujer; Kristine M. Hujer; Gabriel Cabot; Michael Feldgarden; Daniel H. Haft; William Klimke; Focco Van Den Akker; Alejandro J. Vila; Andrea Smania; Shozeb Haider; Krisztina M. Papp-Wallace; Patricia A. Bradford; Gian Maria Rossolini; Jean Denis Docquier; Jean Marie Frère; Moreno Galleni; Nancy D. Hanson; Antonio Oliver; Patrick Plésiat; Laurent Poirel; Patrice Nordmann; Timothy G. Palzkill; George A. Jacoby; Karen Bush; Robert A. Bonomo

doi:10.1128/AAC.01841-19

A standard numbering scheme for class C β-lactamases

Andrew R. Mack, Melissa D. Barnes, Magdalena A. Taracila, Andrea M. Hujer, Kristine M. Hujer, Gabriel Cabot, Michael Feldgarden, Daniel H. Haft, William Klimke, Focco Van Den Akker, Alejandro J. Vila, Andrea Smania, Shozeb Haider, Krisztina M. Papp-Wallace, Patricia A. Bradford, Gian Maria Rossolini, Jean Denis Docquier, Jean Marie Frère, Moreno Galleni, Nancy D. HansonAntonio Oliver, Patrick Plésiat, Laurent Poirel, Patrice Nordmann, Timothy G. Palzkill, George A. Jacoby, Karen Bush, Robert A. Bonomo

Department of Medical Microbiology and Immunology

Research output: Contribution to journal › Article

2 Scopus citations

Abstract

Unlike for classes A and B, a standardized amino acid numbering scheme has not been proposed for the class C (AmpC) β-lactamases, which complicates communication in the field. Here, we propose a scheme developed through a collaborative approach that considers both sequence and structure, preserves traditional numbering of catalytically important residues (Ser⁶⁴, Lys⁶⁷, Tyr¹⁵⁰, and Lys³¹⁵), is adaptable to new variants or enzymes yet to be discovered and includes a variation for genetic and epidemiological applications.

Original language	English (US)
Article number	e01841-19
Journal	Antimicrobial agents and chemotherapy
Volume	64
Issue number	3
DOIs	https://doi.org/10.1128/AAC.01841-19
State	Published - Jan 1 2020

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All Science Journal Classification (ASJC) codes

Pharmacology
Pharmacology (medical)
Infectious Diseases

Cite this

Mack, A. R., Barnes, M. D., Taracila, M. A., Hujer, A. M., Hujer, K. M., Cabot, G., Feldgarden, M., Haft, D. H., Klimke, W., Van Den Akker, F., Vila, A. J., Smania, A., Haider, S., Papp-Wallace, K. M., Bradford, P. A., Rossolini, G. M., Docquier, J. D., Frère, J. M., Galleni, M., ... Bonomo, R. A. (2020). A standard numbering scheme for class C β-lactamases. Antimicrobial agents and chemotherapy, 64(3), [e01841-19]. https://doi.org/10.1128/AAC.01841-19

A standard numbering scheme for class C β-lactamases. / Mack, Andrew R.; Barnes, Melissa D.; Taracila, Magdalena A.; Hujer, Andrea M.; Hujer, Kristine M.; Cabot, Gabriel; Feldgarden, Michael; Haft, Daniel H.; Klimke, William; Van Den Akker, Focco; Vila, Alejandro J.; Smania, Andrea; Haider, Shozeb; Papp-Wallace, Krisztina M.; Bradford, Patricia A.; Rossolini, Gian Maria; Docquier, Jean Denis; Frère, Jean Marie; Galleni, Moreno; Hanson, Nancy D.; Oliver, Antonio; Plésiat, Patrick; Poirel, Laurent; Nordmann, Patrice; Palzkill, Timothy G.; Jacoby, George A.; Bush, Karen; Bonomo, Robert A.

In: Antimicrobial agents and chemotherapy, Vol. 64, No. 3, e01841-19, 01.01.2020.

Research output: Contribution to journal › Article

Mack, AR, Barnes, MD, Taracila, MA, Hujer, AM, Hujer, KM, Cabot, G, Feldgarden, M, Haft, DH, Klimke, W, Van Den Akker, F, Vila, AJ, Smania, A, Haider, S, Papp-Wallace, KM, Bradford, PA, Rossolini, GM, Docquier, JD, Frère, JM, Galleni, M, Hanson, ND, Oliver, A, Plésiat, P, Poirel, L, Nordmann, P, Palzkill, TG, Jacoby, GA, Bush, K & Bonomo, RA 2020, 'A standard numbering scheme for class C β-lactamases', Antimicrobial agents and chemotherapy, vol. 64, no. 3, e01841-19. https://doi.org/10.1128/AAC.01841-19

Mack, Andrew R. ; Barnes, Melissa D. ; Taracila, Magdalena A. ; Hujer, Andrea M. ; Hujer, Kristine M. ; Cabot, Gabriel ; Feldgarden, Michael ; Haft, Daniel H. ; Klimke, William ; Van Den Akker, Focco ; Vila, Alejandro J. ; Smania, Andrea ; Haider, Shozeb ; Papp-Wallace, Krisztina M. ; Bradford, Patricia A. ; Rossolini, Gian Maria ; Docquier, Jean Denis ; Frère, Jean Marie ; Galleni, Moreno ; Hanson, Nancy D. ; Oliver, Antonio ; Plésiat, Patrick ; Poirel, Laurent ; Nordmann, Patrice ; Palzkill, Timothy G. ; Jacoby, George A. ; Bush, Karen ; Bonomo, Robert A. / A standard numbering scheme for class C β-lactamases. In: Antimicrobial agents and chemotherapy. 2020 ; Vol. 64, No. 3.

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10.1128/AAC.01841-19