A standard numbering scheme for class C β-lactamases

Andrew R. Mack, Melissa D. Barnes, Magdalena A. Taracila, Andrea M. Hujer, Kristine M. Hujer, Gabriel Cabot, Michael Feldgarden, Daniel H. Haft, William Klimke, Focco Van Den Akker, Alejandro J. Vila, Andrea Smania, Shozeb Haider, Krisztina M. Papp-Wallace, Patricia A. Bradford, Gian Maria Rossolini, Jean Denis Docquier, Jean Marie Frère, Moreno Galleni, Nancy D. HansonAntonio Oliver, Patrick Plésiat, Laurent Poirel, Patrice Nordmann, Timothy G. Palzkill, George A. Jacoby, Karen Bush, Robert A. Bonomo

Research output: Contribution to journalArticlepeer-review

28 Scopus citations


Unlike for classes A and B, a standardized amino acid numbering scheme has not been proposed for the class C (AmpC) β-lactamases, which complicates communication in the field. Here, we propose a scheme developed through a collaborative approach that considers both sequence and structure, preserves traditional numbering of catalytically important residues (Ser64, Lys67, Tyr150, and Lys315), is adaptable to new variants or enzymes yet to be discovered and includes a variation for genetic and epidemiological applications.

Original languageEnglish (US)
Article numbere01841-19
JournalAntimicrobial agents and chemotherapy
Issue number3
StatePublished - 2020

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases


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