TY - JOUR
T1 - A standard numbering scheme for class C β-lactamases
AU - Mack, Andrew R.
AU - Barnes, Melissa D.
AU - Taracila, Magdalena A.
AU - Hujer, Andrea M.
AU - Hujer, Kristine M.
AU - Cabot, Gabriel
AU - Feldgarden, Michael
AU - Haft, Daniel H.
AU - Klimke, William
AU - Van Den Akker, Focco
AU - Vila, Alejandro J.
AU - Smania, Andrea
AU - Haider, Shozeb
AU - Papp-Wallace, Krisztina M.
AU - Bradford, Patricia A.
AU - Rossolini, Gian Maria
AU - Docquier, Jean Denis
AU - Frère, Jean Marie
AU - Galleni, Moreno
AU - Hanson, Nancy D.
AU - Oliver, Antonio
AU - Plésiat, Patrick
AU - Poirel, Laurent
AU - Nordmann, Patrice
AU - Palzkill, Timothy G.
AU - Jacoby, George A.
AU - Bush, Karen
AU - Bonomo, Robert A.
N1 - Funding Information:
Research reported in this publication was supported by the National Institute of Allergy and Infectious Diseases of the National Institutes of Health (NIH) to R.A.B. under award numbers R01AI100560, R01AI063517, and R01AI072219. This study was also supported in part by funds and/or facilities provided by the Cleveland Department of Veterans Affairs to K.M.P.-W. and R.A.B., Veterans Affairs Merit Review Program award number 1I01BX002872 to K.M.P.-W., Veterans Affairs Merit Review Program award number 1I01BX001974 to R.A.B. from the Biomedical Laboratory Research & Development Service of the VA Office of Research and Development, and by the Geriatric Research Education and Clinical Center VISN 10. The work of Michael Feldgarden, Daniel H. Haft, and William Klimke was supported by the Intramural Research Program of the National Library of Medicine, National Institutes of Health.
PY - 2020
Y1 - 2020
N2 - Unlike for classes A and B, a standardized amino acid numbering scheme has not been proposed for the class C (AmpC) β-lactamases, which complicates communication in the field. Here, we propose a scheme developed through a collaborative approach that considers both sequence and structure, preserves traditional numbering of catalytically important residues (Ser64, Lys67, Tyr150, and Lys315), is adaptable to new variants or enzymes yet to be discovered and includes a variation for genetic and epidemiological applications.
AB - Unlike for classes A and B, a standardized amino acid numbering scheme has not been proposed for the class C (AmpC) β-lactamases, which complicates communication in the field. Here, we propose a scheme developed through a collaborative approach that considers both sequence and structure, preserves traditional numbering of catalytically important residues (Ser64, Lys67, Tyr150, and Lys315), is adaptable to new variants or enzymes yet to be discovered and includes a variation for genetic and epidemiological applications.
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U2 - 10.1128/AAC.01841-19
DO - 10.1128/AAC.01841-19
M3 - Article
C2 - 31712217
AN - SCOPUS:85079905565
VL - 64
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
SN - 0066-4804
IS - 3
M1 - e01841-19
ER -