Aberrantly upregulated trap1 is required for tumorigenesis of breast cancer

Bo Zhang, Jing Wang, Zhen Huang, Peng Wei, Ying Liu, Junfeng Hao, Lijing Zhao, Fenglin Zhang, Yaping Tu, Taotao Wei

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Tumor necrosis factor receptor-associated protein 1 (TRAP1) is abnormally expressed in many cancers. In this study, we showed that TRAP1 is aberrantly upregulated in breast tumors compared to control tissues. TRAP1 knockdown downregulates mitochondrial aerobic respiratory, sensitizes cells to lethal stimuli, and inhibited tumor growth in MDA-MB-231 and MCF-7 breast cancer cells in vivo. TRAP1 overexpression, however, enhances the capacity to cope with stress conditions. These evidences suggested that TRAP1 is required for tumorigenesis. We also found that TRAP1 regulates the mitochondrial morphology. Relatively lower TRAP1 levels are associated with the rod-shaped mitochondrial phenotype in invasive and metastatic MDA-MB-231 breast cancer cells; on the contrary, higher TRAP1 levels are associated with the tubular network-shaped mitochondrial phenotype in non-invasive MCF-7 cells. Interestingly, the expression of TRAP1 in human breast cancer specimens inversely correlates with tumor grade. Overexpression of TRAP1 in MDA-MB-231 cells causes mitochondrial fusion, triggers mitochondria to form tubular networks, and suppresses cell migration and invasion in vitro and in vivo. These data link TRAP1-regulated mitochondrial dynamics and function with tumorigenesis of breast cancer and suggested that TRAP1 may therefore be a potential target for breast cancer drug development.

Original languageEnglish
Pages (from-to)44495-44508
Number of pages14
JournalOncotarget
Volume6
Issue number42
DOIs
StatePublished - 2015

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Tumor Necrosis Factor Receptors
Carcinogenesis
Breast Neoplasms
Proteins
Mitochondrial Dynamics
Phenotype
Neoplasms
MCF-7 Cells
Cell Movement
Mitochondria
Down-Regulation

All Science Journal Classification (ASJC) codes

  • Oncology

Cite this

Zhang, B., Wang, J., Huang, Z., Wei, P., Liu, Y., Hao, J., ... Wei, T. (2015). Aberrantly upregulated trap1 is required for tumorigenesis of breast cancer. Oncotarget, 6(42), 44495-44508. https://doi.org/10.18632/oncotarget.6252

Aberrantly upregulated trap1 is required for tumorigenesis of breast cancer. / Zhang, Bo; Wang, Jing; Huang, Zhen; Wei, Peng; Liu, Ying; Hao, Junfeng; Zhao, Lijing; Zhang, Fenglin; Tu, Yaping; Wei, Taotao.

In: Oncotarget, Vol. 6, No. 42, 2015, p. 44495-44508.

Research output: Contribution to journalArticle

Zhang, B, Wang, J, Huang, Z, Wei, P, Liu, Y, Hao, J, Zhao, L, Zhang, F, Tu, Y & Wei, T 2015, 'Aberrantly upregulated trap1 is required for tumorigenesis of breast cancer', Oncotarget, vol. 6, no. 42, pp. 44495-44508. https://doi.org/10.18632/oncotarget.6252
Zhang, Bo ; Wang, Jing ; Huang, Zhen ; Wei, Peng ; Liu, Ying ; Hao, Junfeng ; Zhao, Lijing ; Zhang, Fenglin ; Tu, Yaping ; Wei, Taotao. / Aberrantly upregulated trap1 is required for tumorigenesis of breast cancer. In: Oncotarget. 2015 ; Vol. 6, No. 42. pp. 44495-44508.
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