Absent or reduced expression of the caspase 8 gene occurs frequently in neuroblastoma, but not commonly in Ewing sarcoma or rhabdomyosarcoma

Junko Takita; Hong Wei Yang; Fumio Bessho; Ryoji Hanada; Keiko Yamamoto; Vincent Kidd; Tal Teitz; Tie Wei; Yasuhide Hayashi

doi:10.1002/1096-911X(20001201)35:6<541::AID-MPO9>3.0.CO;2-T

Absent or reduced expression of the caspase 8 gene occurs frequently in neuroblastoma, but not commonly in Ewing sarcoma or rhabdomyosarcoma

Junko Takita, Hong Wei Yang, Fumio Bessho, Ryoji Hanada, Keiko Yamamoto, Vincent Kidd, Tal Teitz, Tie Wei, Yasuhide Hayashi

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

Procedure. To clarify whether the caspase 8 gene is involved in the pathogenesis of neuroblastoma (NB), we examined alterations of the caspase 8 gene in 15 NB, seven Ewing sarcoma (ES), and eight rhabdomyosarcoma (RMS) cell lines, using reverse transcription-polymerase chain reaction (RT-PCR) and RT-PCR singlestrand conformation polymorphism (SSCP) analyses. Results. The caspase 8 gene was not expressed in 11 (73%) of 15 NB cell lines, it was absent in only one of seven ES cell lines, but was present in all eight RMS cell lines examined. No mutations were detected in any cell lines examined. Conclusions. Inactivation of the caspase 8 gene is considered to be involved in the pathogenesis of NB, but not ES or RMS. (C) 2000 Wiley-Liss, Inc.

Original language	English (US)
Pages (from-to)	541-543
Number of pages	3
Journal	Medical and Pediatric Oncology
Volume	35
Issue number	6
DOIs	https://doi.org/10.1002/1096-911X(20001201)35:6<541::AID-MPO9>3.0.CO;2-T
State	Published - 2000
Externally published	Yes

All Science Journal Classification (ASJC) codes

Pediatrics, Perinatology, and Child Health
Oncology
Cancer Research

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10.1002/1096-911X(20001201)35:6<541::AID-MPO9>3.0.CO;2-T

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Takita, J., Yang, H. W., Bessho, F., Hanada, R., Yamamoto, K., Kidd, V., Teitz, T., Wei, T., & Hayashi, Y. (2000). Absent or reduced expression of the caspase 8 gene occurs frequently in neuroblastoma, but not commonly in Ewing sarcoma or rhabdomyosarcoma. Medical and Pediatric Oncology, 35(6), 541-543. https://doi.org/10.1002/1096-911X(20001201)35:6<541::AID-MPO9>3.0.CO;2-T

Takita, J, Yang, HW, Bessho, F, Hanada, R, Yamamoto, K, Kidd, V, Teitz, T, Wei, T & Hayashi, Y 2000, 'Absent or reduced expression of the caspase 8 gene occurs frequently in neuroblastoma, but not commonly in Ewing sarcoma or rhabdomyosarcoma', Medical and Pediatric Oncology, vol. 35, no. 6, pp. 541-543. https://doi.org/10.1002/1096-911X(20001201)35:6<541::AID-MPO9>3.0.CO;2-T

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title = "Absent or reduced expression of the caspase 8 gene occurs frequently in neuroblastoma, but not commonly in Ewing sarcoma or rhabdomyosarcoma",

abstract = "Procedure. To clarify whether the caspase 8 gene is involved in the pathogenesis of neuroblastoma (NB), we examined alterations of the caspase 8 gene in 15 NB, seven Ewing sarcoma (ES), and eight rhabdomyosarcoma (RMS) cell lines, using reverse transcription-polymerase chain reaction (RT-PCR) and RT-PCR singlestrand conformation polymorphism (SSCP) analyses. Results. The caspase 8 gene was not expressed in 11 (73%) of 15 NB cell lines, it was absent in only one of seven ES cell lines, but was present in all eight RMS cell lines examined. No mutations were detected in any cell lines examined. Conclusions. Inactivation of the caspase 8 gene is considered to be involved in the pathogenesis of NB, but not ES or RMS. (C) 2000 Wiley-Liss, Inc.",

author = "Junko Takita and Yang, {Hong Wei} and Fumio Bessho and Ryoji Hanada and Keiko Yamamoto and Vincent Kidd and Tal Teitz and Tie Wei and Yasuhide Hayashi",

year = "2000",

doi = "10.1002/1096-911X(20001201)35:6<541::AID-MPO9>3.0.CO;2-T",

language = "English (US)",

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pages = "541--543",

journal = "Medical and Pediatric Oncology",

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TY - JOUR

T1 - Absent or reduced expression of the caspase 8 gene occurs frequently in neuroblastoma, but not commonly in Ewing sarcoma or rhabdomyosarcoma

AU - Takita, Junko

AU - Yang, Hong Wei

AU - Bessho, Fumio

AU - Hanada, Ryoji

AU - Yamamoto, Keiko

AU - Kidd, Vincent

AU - Teitz, Tal

AU - Wei, Tie

AU - Hayashi, Yasuhide

PY - 2000

Y1 - 2000

N2 - Procedure. To clarify whether the caspase 8 gene is involved in the pathogenesis of neuroblastoma (NB), we examined alterations of the caspase 8 gene in 15 NB, seven Ewing sarcoma (ES), and eight rhabdomyosarcoma (RMS) cell lines, using reverse transcription-polymerase chain reaction (RT-PCR) and RT-PCR singlestrand conformation polymorphism (SSCP) analyses. Results. The caspase 8 gene was not expressed in 11 (73%) of 15 NB cell lines, it was absent in only one of seven ES cell lines, but was present in all eight RMS cell lines examined. No mutations were detected in any cell lines examined. Conclusions. Inactivation of the caspase 8 gene is considered to be involved in the pathogenesis of NB, but not ES or RMS. (C) 2000 Wiley-Liss, Inc.

AB - Procedure. To clarify whether the caspase 8 gene is involved in the pathogenesis of neuroblastoma (NB), we examined alterations of the caspase 8 gene in 15 NB, seven Ewing sarcoma (ES), and eight rhabdomyosarcoma (RMS) cell lines, using reverse transcription-polymerase chain reaction (RT-PCR) and RT-PCR singlestrand conformation polymorphism (SSCP) analyses. Results. The caspase 8 gene was not expressed in 11 (73%) of 15 NB cell lines, it was absent in only one of seven ES cell lines, but was present in all eight RMS cell lines examined. No mutations were detected in any cell lines examined. Conclusions. Inactivation of the caspase 8 gene is considered to be involved in the pathogenesis of NB, but not ES or RMS. (C) 2000 Wiley-Liss, Inc.

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ER -

Absent or reduced expression of the caspase 8 gene occurs frequently in neuroblastoma, but not commonly in Ewing sarcoma or rhabdomyosarcoma

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