TY - JOUR
T1 - Absent or reduced expression of the caspase 8 gene occurs frequently in neuroblastoma, but not commonly in Ewing sarcoma or rhabdomyosarcoma
AU - Takita, Junko
AU - Yang, Hong Wei
AU - Bessho, Fumio
AU - Hanada, Ryoji
AU - Yamamoto, Keiko
AU - Kidd, Vincent
AU - Teitz, Tal
AU - Wei, Tie
AU - Hayashi, Yasuhide
PY - 2000
Y1 - 2000
N2 - Procedure. To clarify whether the caspase 8 gene is involved in the pathogenesis of neuroblastoma (NB), we examined alterations of the caspase 8 gene in 15 NB, seven Ewing sarcoma (ES), and eight rhabdomyosarcoma (RMS) cell lines, using reverse transcription-polymerase chain reaction (RT-PCR) and RT-PCR singlestrand conformation polymorphism (SSCP) analyses. Results. The caspase 8 gene was not expressed in 11 (73%) of 15 NB cell lines, it was absent in only one of seven ES cell lines, but was present in all eight RMS cell lines examined. No mutations were detected in any cell lines examined. Conclusions. Inactivation of the caspase 8 gene is considered to be involved in the pathogenesis of NB, but not ES or RMS. (C) 2000 Wiley-Liss, Inc.
AB - Procedure. To clarify whether the caspase 8 gene is involved in the pathogenesis of neuroblastoma (NB), we examined alterations of the caspase 8 gene in 15 NB, seven Ewing sarcoma (ES), and eight rhabdomyosarcoma (RMS) cell lines, using reverse transcription-polymerase chain reaction (RT-PCR) and RT-PCR singlestrand conformation polymorphism (SSCP) analyses. Results. The caspase 8 gene was not expressed in 11 (73%) of 15 NB cell lines, it was absent in only one of seven ES cell lines, but was present in all eight RMS cell lines examined. No mutations were detected in any cell lines examined. Conclusions. Inactivation of the caspase 8 gene is considered to be involved in the pathogenesis of NB, but not ES or RMS. (C) 2000 Wiley-Liss, Inc.
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U2 - 10.1002/1096-911X(20001201)35:6<541::AID-MPO9>3.0.CO;2-T
DO - 10.1002/1096-911X(20001201)35:6<541::AID-MPO9>3.0.CO;2-T
M3 - Article
C2 - 11107112
AN - SCOPUS:0033658582
VL - 35
SP - 541
EP - 543
JO - Medical and Pediatric Oncology
JF - Medical and Pediatric Oncology
SN - 1545-5009
IS - 6
ER -