Absorption from different intestinal segments during exercise

G. Patrick Lambert, R. T. Chang, T. Xia, R. W. Summers, C. V. Gisolfi

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

This study evaluated intestinal absorption from the first 75 cm of the proximal small intestine during 85 min of cycle exercise [63.6 ± 0.7% peak O2 consumption (V̇O(2peak))] while subjects ingested either an isotonic carbohydrate-electrolyte beverage (CHO-E) or a water placebo (WP). The CHO- E beverage contained 117 mM (4%) sucrose, 111 mM (2%) glucose, 18 meq Na+, and 3 meq K+. The two experiments were performed.a week apart by seven subjects (6 men and 1 woman; mean V̇O(2peak) = 53.5 ± 6.5 ml · kg-1 · min-1). Nasogastric and multilumen tubes were fluoroscopically positioned in the gastric antrum and duodenojejunum, respectively. Subjects ingested 23 ml/kg body weight of the test solution, 20% (383 ± 11 ml) of this volume 5 min before exercise and 10% (191 ± 5 ml) every 10 min thereafter. By using the rate of gastric emptying (18.1 ± 1.1 vs. 19.2 ± 0.7 ml/min for WP and CHO-E, respectively) as the rate of intestinal perfusion, intestinal absorption was determined by segmental perfusion from the duodenum (0-25 cm) and jejunum (25-50 and 50-75 cm). Water flux was different (P < 0.05) between solutions in the 0- to 25- and 25- to 50-cm segments for WP vs. CHO- E (30.7 ± 2.7 vs. 15.0 ± 2.9 and 3.8 ± 1.1 vs. 11.9 ± 3.3 ml · cm-1 · h-1 respectively). Furthermore, water flux differed (P < 0.05) for WP in a comparison of the 0- to 25- to the 25- to 50-cm segment. Total solute flux (TSF) was not significantly different among segments for a given solution or between solutions for a given segment. There was no difference between trials for percent change in plasma volume. These results indicate that 1) fluid absorption in the proximal small intestine depends on the segment studied and 2) solution composition can significantly effect water absorption rate in different intestinal segments.

Original languageEnglish (US)
Pages (from-to)204-212
Number of pages9
JournalJournal of Applied Physiology
Volume83
Issue number1
StatePublished - Jul 1 1997
Externally publishedYes

Fingerprint

Intestinal Absorption
Exercise
Water
Placebos
Beverages
Small Intestine
Perfusion
Pyloric Antrum
Plasma Volume
Gastric Emptying
Jejunum
Duodenum
Electrolytes
Sucrose
Body Weight
Carbohydrates
Glucose

All Science Journal Classification (ASJC) codes

  • Physiology
  • Physiology (medical)

Cite this

Lambert, G. P., Chang, R. T., Xia, T., Summers, R. W., & Gisolfi, C. V. (1997). Absorption from different intestinal segments during exercise. Journal of Applied Physiology, 83(1), 204-212.

Absorption from different intestinal segments during exercise. / Lambert, G. Patrick; Chang, R. T.; Xia, T.; Summers, R. W.; Gisolfi, C. V.

In: Journal of Applied Physiology, Vol. 83, No. 1, 01.07.1997, p. 204-212.

Research output: Contribution to journalArticle

Lambert, GP, Chang, RT, Xia, T, Summers, RW & Gisolfi, CV 1997, 'Absorption from different intestinal segments during exercise', Journal of Applied Physiology, vol. 83, no. 1, pp. 204-212.
Lambert GP, Chang RT, Xia T, Summers RW, Gisolfi CV. Absorption from different intestinal segments during exercise. Journal of Applied Physiology. 1997 Jul 1;83(1):204-212.
Lambert, G. Patrick ; Chang, R. T. ; Xia, T. ; Summers, R. W. ; Gisolfi, C. V. / Absorption from different intestinal segments during exercise. In: Journal of Applied Physiology. 1997 ; Vol. 83, No. 1. pp. 204-212.
@article{e62914a24a6944738612cccbccd9ff3a,
title = "Absorption from different intestinal segments during exercise",
abstract = "This study evaluated intestinal absorption from the first 75 cm of the proximal small intestine during 85 min of cycle exercise [63.6 ± 0.7{\%} peak O2 consumption (V̇O(2peak))] while subjects ingested either an isotonic carbohydrate-electrolyte beverage (CHO-E) or a water placebo (WP). The CHO- E beverage contained 117 mM (4{\%}) sucrose, 111 mM (2{\%}) glucose, 18 meq Na+, and 3 meq K+. The two experiments were performed.a week apart by seven subjects (6 men and 1 woman; mean V̇O(2peak) = 53.5 ± 6.5 ml · kg-1 · min-1). Nasogastric and multilumen tubes were fluoroscopically positioned in the gastric antrum and duodenojejunum, respectively. Subjects ingested 23 ml/kg body weight of the test solution, 20{\%} (383 ± 11 ml) of this volume 5 min before exercise and 10{\%} (191 ± 5 ml) every 10 min thereafter. By using the rate of gastric emptying (18.1 ± 1.1 vs. 19.2 ± 0.7 ml/min for WP and CHO-E, respectively) as the rate of intestinal perfusion, intestinal absorption was determined by segmental perfusion from the duodenum (0-25 cm) and jejunum (25-50 and 50-75 cm). Water flux was different (P < 0.05) between solutions in the 0- to 25- and 25- to 50-cm segments for WP vs. CHO- E (30.7 ± 2.7 vs. 15.0 ± 2.9 and 3.8 ± 1.1 vs. 11.9 ± 3.3 ml · cm-1 · h-1 respectively). Furthermore, water flux differed (P < 0.05) for WP in a comparison of the 0- to 25- to the 25- to 50-cm segment. Total solute flux (TSF) was not significantly different among segments for a given solution or between solutions for a given segment. There was no difference between trials for percent change in plasma volume. These results indicate that 1) fluid absorption in the proximal small intestine depends on the segment studied and 2) solution composition can significantly effect water absorption rate in different intestinal segments.",
author = "Lambert, {G. Patrick} and Chang, {R. T.} and T. Xia and Summers, {R. W.} and Gisolfi, {C. V.}",
year = "1997",
month = "7",
day = "1",
language = "English (US)",
volume = "83",
pages = "204--212",
journal = "Journal of Applied Physiology",
issn = "8750-7587",
publisher = "American Physiological Society",
number = "1",

}

TY - JOUR

T1 - Absorption from different intestinal segments during exercise

AU - Lambert, G. Patrick

AU - Chang, R. T.

AU - Xia, T.

AU - Summers, R. W.

AU - Gisolfi, C. V.

PY - 1997/7/1

Y1 - 1997/7/1

N2 - This study evaluated intestinal absorption from the first 75 cm of the proximal small intestine during 85 min of cycle exercise [63.6 ± 0.7% peak O2 consumption (V̇O(2peak))] while subjects ingested either an isotonic carbohydrate-electrolyte beverage (CHO-E) or a water placebo (WP). The CHO- E beverage contained 117 mM (4%) sucrose, 111 mM (2%) glucose, 18 meq Na+, and 3 meq K+. The two experiments were performed.a week apart by seven subjects (6 men and 1 woman; mean V̇O(2peak) = 53.5 ± 6.5 ml · kg-1 · min-1). Nasogastric and multilumen tubes were fluoroscopically positioned in the gastric antrum and duodenojejunum, respectively. Subjects ingested 23 ml/kg body weight of the test solution, 20% (383 ± 11 ml) of this volume 5 min before exercise and 10% (191 ± 5 ml) every 10 min thereafter. By using the rate of gastric emptying (18.1 ± 1.1 vs. 19.2 ± 0.7 ml/min for WP and CHO-E, respectively) as the rate of intestinal perfusion, intestinal absorption was determined by segmental perfusion from the duodenum (0-25 cm) and jejunum (25-50 and 50-75 cm). Water flux was different (P < 0.05) between solutions in the 0- to 25- and 25- to 50-cm segments for WP vs. CHO- E (30.7 ± 2.7 vs. 15.0 ± 2.9 and 3.8 ± 1.1 vs. 11.9 ± 3.3 ml · cm-1 · h-1 respectively). Furthermore, water flux differed (P < 0.05) for WP in a comparison of the 0- to 25- to the 25- to 50-cm segment. Total solute flux (TSF) was not significantly different among segments for a given solution or between solutions for a given segment. There was no difference between trials for percent change in plasma volume. These results indicate that 1) fluid absorption in the proximal small intestine depends on the segment studied and 2) solution composition can significantly effect water absorption rate in different intestinal segments.

AB - This study evaluated intestinal absorption from the first 75 cm of the proximal small intestine during 85 min of cycle exercise [63.6 ± 0.7% peak O2 consumption (V̇O(2peak))] while subjects ingested either an isotonic carbohydrate-electrolyte beverage (CHO-E) or a water placebo (WP). The CHO- E beverage contained 117 mM (4%) sucrose, 111 mM (2%) glucose, 18 meq Na+, and 3 meq K+. The two experiments were performed.a week apart by seven subjects (6 men and 1 woman; mean V̇O(2peak) = 53.5 ± 6.5 ml · kg-1 · min-1). Nasogastric and multilumen tubes were fluoroscopically positioned in the gastric antrum and duodenojejunum, respectively. Subjects ingested 23 ml/kg body weight of the test solution, 20% (383 ± 11 ml) of this volume 5 min before exercise and 10% (191 ± 5 ml) every 10 min thereafter. By using the rate of gastric emptying (18.1 ± 1.1 vs. 19.2 ± 0.7 ml/min for WP and CHO-E, respectively) as the rate of intestinal perfusion, intestinal absorption was determined by segmental perfusion from the duodenum (0-25 cm) and jejunum (25-50 and 50-75 cm). Water flux was different (P < 0.05) between solutions in the 0- to 25- and 25- to 50-cm segments for WP vs. CHO- E (30.7 ± 2.7 vs. 15.0 ± 2.9 and 3.8 ± 1.1 vs. 11.9 ± 3.3 ml · cm-1 · h-1 respectively). Furthermore, water flux differed (P < 0.05) for WP in a comparison of the 0- to 25- to the 25- to 50-cm segment. Total solute flux (TSF) was not significantly different among segments for a given solution or between solutions for a given segment. There was no difference between trials for percent change in plasma volume. These results indicate that 1) fluid absorption in the proximal small intestine depends on the segment studied and 2) solution composition can significantly effect water absorption rate in different intestinal segments.

UR - http://www.scopus.com/inward/record.url?scp=0030795669&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030795669&partnerID=8YFLogxK

M3 - Article

C2 - 9216965

AN - SCOPUS:0030795669

VL - 83

SP - 204

EP - 212

JO - Journal of Applied Physiology

JF - Journal of Applied Physiology

SN - 8750-7587

IS - 1

ER -