ACROMEGALY AND PITUITARY ADENOMA WITH PHAEOCHROMOCYTOMA: A VARIANT OF MULTIPLE ENDOCRINE NEOPLASIA

R. J. ANDERSON, E. G. LUFKIN, G. W. SIZEMORE, J. A. CARNEY, S. G. SHEPS, Y. E. SILLIMAN

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Abstract

Two women had acromegaly due to a pituitary adenoma associated with phaeochromocytoma. Eight additional patients with this combination of tumours have been described by others. Our first patient had sustained hypertension, mild hypercalcaemia, and elevated basal levels of parathyroid hormone and calcitonin associated with malignant phaeochromocytoma and parathyroid hyperplasia. The second patient had episodic hypertension and normal basal serum calcium, parathyroid hormone, and calcitonin levels with a benign cystic phaeochromocytoma. Three patients had parathyroid hyperplasia. A separate group of four patients with phaeochromocytoma and pituitary adenoma without acromegaly has also been reported. These fourteen patients probably represent a non-familial variant of the multiple endocrine neoplasia syndrome. Our findings suggest that acromegalic patients with hyertension should be screened for phaeochromocytoma.

Original languageEnglish (US)
Pages (from-to)605-612
Number of pages8
JournalClinical Endocrinology
Volume14
Issue number6
DOIs
StatePublished - Jun 1981

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All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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