Activation of adenosine A1 receptors underlies anticonvulsant effect of CGS21680

Ge Zhang, Paul H. Franklin, Thomas F. Murray

Research output: Contribution to journalArticlepeer-review

43 Scopus citations


Focal injection of the adenosine A2A receptor agonist CGS21680 (2-[p-(2-carboxyethyl)phenylethylamino]-5′-N-ethyl-carboxamidoadenosine) in the rat prepiriform cortex produced a reduction in the severity of bicuculline methiodide-induced motor seizures. The anticonvulsant effect of CGS21680 exhibited dose-dependency and modest potency (ED50=605±47 pmol/rat). Pharmacological characterization of the anticonvulsant response in the prepiriform cortex revealed a significant correlation between the potency of adenosine analogs as anticonvulsants and their respective affinities for adenosine A1 receptors in vitro. These results indicate that the low affinity of CGS21680 for adenosine A1 receptors is sufficient to account for the anticonvulsant activity of this compound in the rat prepiriform cortex.

Original languageEnglish (US)
Pages (from-to)239-243
Number of pages5
JournalEuropean Journal of Pharmacology
Issue number1-3
StatePublished - Apr 1 1994
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pharmacology


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