Abstract
Objective: Lymphocyte proliferative responses are commonly used to assess immune function in clinical settings, yet it is unclear how proliferative capacity is altered by exercise. This analysis aims to quantitatively assess the proliferative response of lymphocytes following an acute bout of exercise. Methods: Electronic databases were searched for articles containing the keywords "exercise" OR "acute" OR "aerobic" OR "resistance training" OR "immune function" AND "proliferation" AND "lymphocyte." Initial results yielded 517 articles of which 117 were reviewed in full. Twenty-four articles met the inclusion criteria. Calculated standardized mean difference (SMD) and corresponding standard errors (SE) were integrated using random-effect models. Results: Analyses uncovered evidence for suppression of proliferative capacity following acute exercise in general (SMD = -0.18, 95% CI: -0.21, -0.16) with long duration, high intensity exercise exhibiting a moderate suppressive effect (SMD = -0.55, 95% CI: -0.86, -0.24). Discordant proliferative responses for long duration, high intensity exercise in competitive versus non-competitive settings were identified with enhanced proliferation (SMD = 0.46, 95% CI: 0.03, 0.89) observed following competitive events and a large suppressive effect detected for similar activities outside of a competitive environment (SMD: -1.28, 95% CI: -1.61, -0.96) (p = 0.02). Conclusion: Evidence suggests lymphocyte proliferation is suppressed following acute bouts of exercise, with exercise lasting longer than one hour having a greater magnitude of effect regardless of exercise intensity. Variations in observed effect sizes across intensity, duration, and competitive environment further highlight our need to acknowledge the impact of study designs in advancing our understanding of exercise immunology.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 343-351 |
| Number of pages | 9 |
| Journal | Brain, Behavior, and Immunity |
| Volume | 56 |
| DOIs | |
| State | Published - Aug 1 2016 |
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All Science Journal Classification (ASJC) codes
- Immunology
- Endocrine and Autonomic Systems
- Behavioral Neuroscience
Cite this
Acute bouts of exercise induce a suppressive effect on lymphocyte proliferation in human subjects : A meta-analysis. / Siedlik, Jacob A.; Benedict, Stephen H.; Landes, Evan J.; Weir, Joseph P.; Vardiman, John P.; Gallagher, Philip M.
In: Brain, Behavior, and Immunity, Vol. 56, 01.08.2016, p. 343-351.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Acute bouts of exercise induce a suppressive effect on lymphocyte proliferation in human subjects
T2 - A meta-analysis
AU - Siedlik, Jacob A.
AU - Benedict, Stephen H.
AU - Landes, Evan J.
AU - Weir, Joseph P.
AU - Vardiman, John P.
AU - Gallagher, Philip M.
PY - 2016/8/1
Y1 - 2016/8/1
N2 - Objective: Lymphocyte proliferative responses are commonly used to assess immune function in clinical settings, yet it is unclear how proliferative capacity is altered by exercise. This analysis aims to quantitatively assess the proliferative response of lymphocytes following an acute bout of exercise. Methods: Electronic databases were searched for articles containing the keywords "exercise" OR "acute" OR "aerobic" OR "resistance training" OR "immune function" AND "proliferation" AND "lymphocyte." Initial results yielded 517 articles of which 117 were reviewed in full. Twenty-four articles met the inclusion criteria. Calculated standardized mean difference (SMD) and corresponding standard errors (SE) were integrated using random-effect models. Results: Analyses uncovered evidence for suppression of proliferative capacity following acute exercise in general (SMD = -0.18, 95% CI: -0.21, -0.16) with long duration, high intensity exercise exhibiting a moderate suppressive effect (SMD = -0.55, 95% CI: -0.86, -0.24). Discordant proliferative responses for long duration, high intensity exercise in competitive versus non-competitive settings were identified with enhanced proliferation (SMD = 0.46, 95% CI: 0.03, 0.89) observed following competitive events and a large suppressive effect detected for similar activities outside of a competitive environment (SMD: -1.28, 95% CI: -1.61, -0.96) (p = 0.02). Conclusion: Evidence suggests lymphocyte proliferation is suppressed following acute bouts of exercise, with exercise lasting longer than one hour having a greater magnitude of effect regardless of exercise intensity. Variations in observed effect sizes across intensity, duration, and competitive environment further highlight our need to acknowledge the impact of study designs in advancing our understanding of exercise immunology.
AB - Objective: Lymphocyte proliferative responses are commonly used to assess immune function in clinical settings, yet it is unclear how proliferative capacity is altered by exercise. This analysis aims to quantitatively assess the proliferative response of lymphocytes following an acute bout of exercise. Methods: Electronic databases were searched for articles containing the keywords "exercise" OR "acute" OR "aerobic" OR "resistance training" OR "immune function" AND "proliferation" AND "lymphocyte." Initial results yielded 517 articles of which 117 were reviewed in full. Twenty-four articles met the inclusion criteria. Calculated standardized mean difference (SMD) and corresponding standard errors (SE) were integrated using random-effect models. Results: Analyses uncovered evidence for suppression of proliferative capacity following acute exercise in general (SMD = -0.18, 95% CI: -0.21, -0.16) with long duration, high intensity exercise exhibiting a moderate suppressive effect (SMD = -0.55, 95% CI: -0.86, -0.24). Discordant proliferative responses for long duration, high intensity exercise in competitive versus non-competitive settings were identified with enhanced proliferation (SMD = 0.46, 95% CI: 0.03, 0.89) observed following competitive events and a large suppressive effect detected for similar activities outside of a competitive environment (SMD: -1.28, 95% CI: -1.61, -0.96) (p = 0.02). Conclusion: Evidence suggests lymphocyte proliferation is suppressed following acute bouts of exercise, with exercise lasting longer than one hour having a greater magnitude of effect regardless of exercise intensity. Variations in observed effect sizes across intensity, duration, and competitive environment further highlight our need to acknowledge the impact of study designs in advancing our understanding of exercise immunology.
UR - http://www.scopus.com/inward/record.url?scp=84964395595&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84964395595&partnerID=8YFLogxK
U2 - 10.1016/j.bbi.2016.04.008
DO - 10.1016/j.bbi.2016.04.008
M3 - Article
C2 - 27103377
AN - SCOPUS:84964395595
VL - 56
SP - 343
EP - 351
JO - Brain, Behavior, and Immunity
JF - Brain, Behavior, and Immunity
SN - 0889-1591
ER -