Adenosine in myocardial perfusion imaging using positron emission tomography

Naresh C. Gupta, Dennis J. Esterbrooks, Syed M. Mohiuddin, Daniel E. Hilleman, John Sunderland, Chyng Y. Shiue, Mathis P. Frick

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Because of its unique ability to demonstrate the metabolic consequences of myocardial ischemia, positron emission tomography (PET) is extremely valuable in assessing myocardial viability. PET imaging can identify the myocardial segments that are likely to improve after revascularization and may be more sensitive and specific for the detection of coronary artery disease compared with thallium perfusion imaging. Adenosine has several advantages over dipyridamole as a pharmacologic stress agent for use with PET. It produces maximal vasodilation in a significantly greater percentage of patients, is a more potent coronary vasodilator, and its very short half-life may be ideal for use with the very short half-life radioactive tracers used in PET. When combined with metabolic studies, adenosine may be useful for the assessment of patients who received thrombolytic therapy for an acute myocardial infarction.

Original languageEnglish
Pages (from-to)293-301
Number of pages9
JournalAmerican Heart Journal
Volume122
Issue number1 PART 1
DOIs
StatePublished - 1991

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Myocardial Perfusion Imaging
Positron-Emission Tomography
Adenosine
Half-Life
Radioactive Tracers
Perfusion Imaging
Dipyridamole
Thallium
Thrombolytic Therapy
Vasodilator Agents
Vasodilation
Myocardial Ischemia
Coronary Artery Disease
Myocardial Infarction

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Adenosine in myocardial perfusion imaging using positron emission tomography. / Gupta, Naresh C.; Esterbrooks, Dennis J.; Mohiuddin, Syed M.; Hilleman, Daniel E.; Sunderland, John; Shiue, Chyng Y.; Frick, Mathis P.

In: American Heart Journal, Vol. 122, No. 1 PART 1, 1991, p. 293-301.

Research output: Contribution to journalArticle

Gupta, Naresh C. ; Esterbrooks, Dennis J. ; Mohiuddin, Syed M. ; Hilleman, Daniel E. ; Sunderland, John ; Shiue, Chyng Y. ; Frick, Mathis P. / Adenosine in myocardial perfusion imaging using positron emission tomography. In: American Heart Journal. 1991 ; Vol. 122, No. 1 PART 1. pp. 293-301.
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