TY - JOUR
T1 - Adjunctive Minocycline for Treatment of Posttraumatic Stress Disorder
AU - Gerst, Anna
AU - Murthy, Tej
AU - Elson, Alisandrea
AU - Driscoll, David
AU - Bittner, Marvin J.
AU - Ramaswamy, Sriram
N1 - Publisher Copyright:
Copyright© Board of Regents of the University of Wisconsin System and The Medical College of Wisconsin, Inc.
PY - 2021/12/1
Y1 - 2021/12/1
N2 - INTRODUCTION: Posttraumatic stress disorder (PTSD) is a chronic, debilitating anxiety disorder. While there is evidence that antibiotics such as minocycline may help to improve symptoms in some psychiatric disorders, no human studies have evaluated their potential as a treatment for PTSD. METHODS: We present results from 4 men aged 33 to 59 years who completed a 12-week pilot, prospective, nonrandomized, open-label clinical trial of adjunctive minocycline for veterans diagnosed with PTSD. RESULTS: All 4 patients showed reduction in PTSD symptoms at the end of the 12-week study, and 3 patients showed reduction in depression symptoms. Observed changes in inflammatory biomarkers are discussed. DISCUSSION: Previous studies have reported increased inflammation in PTSD, though evidence of a potential therapeutic effect of minocycline for PTSD has not been reported previously in humans. CONCLUSION: These findings suggest that antibiotics like minocycline may help to reduce symptoms of PTSD, though further investigation is needed to confirm these findings.
AB - INTRODUCTION: Posttraumatic stress disorder (PTSD) is a chronic, debilitating anxiety disorder. While there is evidence that antibiotics such as minocycline may help to improve symptoms in some psychiatric disorders, no human studies have evaluated their potential as a treatment for PTSD. METHODS: We present results from 4 men aged 33 to 59 years who completed a 12-week pilot, prospective, nonrandomized, open-label clinical trial of adjunctive minocycline for veterans diagnosed with PTSD. RESULTS: All 4 patients showed reduction in PTSD symptoms at the end of the 12-week study, and 3 patients showed reduction in depression symptoms. Observed changes in inflammatory biomarkers are discussed. DISCUSSION: Previous studies have reported increased inflammation in PTSD, though evidence of a potential therapeutic effect of minocycline for PTSD has not been reported previously in humans. CONCLUSION: These findings suggest that antibiotics like minocycline may help to reduce symptoms of PTSD, though further investigation is needed to confirm these findings.
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M3 - Article
C2 - 35025183
AN - SCOPUS:85123459756
VL - 120
SP - 321
EP - 324
JO - Wisconsin Medical Journal
JF - Wisconsin Medical Journal
SN - 0043-6542
IS - 4
ER -