Abstract
OBJECTIVE - Carbohydrate counting is an effective approach to mealtime insulin adjustment in type 1 diabetes but has not been rigorously assessed in type 2 diabetes. We sought to compare an insulin-to-carbohydrate ratio with a simple algorithm for adjusting the dose of prandial insulin glusiline. RESEARCH AND DESIGN METHODS - This 24-week, multicenter, randomized, controlled study compared two algorithms for adjusting mealtime (glulisine) insulin along with a standard algorithm for adjusting background (glargine) insulin in 273 intent-to-treat patients with type 2 diabetes. Glulisine and glargine were adjusted weekly in both groups based on self-monitored blood glucose (SMBG) results from the previous week. The simple algorithm group was provided set doses of glulisine to take before each meal. The carbohydrate counting (carb count) group was provided an insulin-to-carbohydrate ratio to use for each meal and adjusted their glulisine dose based on the amount of carbohydrate consumed. RESULTS - A1C levels at week 24 were 6.70% (simple algorithm) and 6.54% (carb count). The respective mean A1C changes from baseline to 24 weeks were -1.46 and -1.59% (P = 0.24). A1C
| Original language | English |
|---|---|
| Pages (from-to) | 1305-1310 |
| Number of pages | 6 |
| Journal | Diabetes Care |
| Volume | 31 |
| Issue number | 7 |
| DOIs | |
| State | Published - Jul 2008 |
Fingerprint
All Science Journal Classification (ASJC) codes
- Internal Medicine
- Endocrinology, Diabetes and Metabolism
- Advanced and Specialized Nursing
Cite this
Adjust to target in type 2 diabetes : Comparison of a simple algorithm with carbohydrate counting for adjustment of mealtime insulin glulisine. / Bergenstal, Richard M.; Johnson, Mary; Powers, Margaret A.; Wynne, Alan; Vlajnic, Aleksandra; Hollander, Priscilla; Rendell, Marc.
In: Diabetes Care, Vol. 31, No. 7, 07.2008, p. 1305-1310.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Adjust to target in type 2 diabetes
T2 - Comparison of a simple algorithm with carbohydrate counting for adjustment of mealtime insulin glulisine
AU - Bergenstal, Richard M.
AU - Johnson, Mary
AU - Powers, Margaret A.
AU - Wynne, Alan
AU - Vlajnic, Aleksandra
AU - Hollander, Priscilla
AU - Rendell, Marc
PY - 2008/7
Y1 - 2008/7
N2 - OBJECTIVE - Carbohydrate counting is an effective approach to mealtime insulin adjustment in type 1 diabetes but has not been rigorously assessed in type 2 diabetes. We sought to compare an insulin-to-carbohydrate ratio with a simple algorithm for adjusting the dose of prandial insulin glusiline. RESEARCH AND DESIGN METHODS - This 24-week, multicenter, randomized, controlled study compared two algorithms for adjusting mealtime (glulisine) insulin along with a standard algorithm for adjusting background (glargine) insulin in 273 intent-to-treat patients with type 2 diabetes. Glulisine and glargine were adjusted weekly in both groups based on self-monitored blood glucose (SMBG) results from the previous week. The simple algorithm group was provided set doses of glulisine to take before each meal. The carbohydrate counting (carb count) group was provided an insulin-to-carbohydrate ratio to use for each meal and adjusted their glulisine dose based on the amount of carbohydrate consumed. RESULTS - A1C levels at week 24 were 6.70% (simple algorithm) and 6.54% (carb count). The respective mean A1C changes from baseline to 24 weeks were -1.46 and -1.59% (P = 0.24). A1C
AB - OBJECTIVE - Carbohydrate counting is an effective approach to mealtime insulin adjustment in type 1 diabetes but has not been rigorously assessed in type 2 diabetes. We sought to compare an insulin-to-carbohydrate ratio with a simple algorithm for adjusting the dose of prandial insulin glusiline. RESEARCH AND DESIGN METHODS - This 24-week, multicenter, randomized, controlled study compared two algorithms for adjusting mealtime (glulisine) insulin along with a standard algorithm for adjusting background (glargine) insulin in 273 intent-to-treat patients with type 2 diabetes. Glulisine and glargine were adjusted weekly in both groups based on self-monitored blood glucose (SMBG) results from the previous week. The simple algorithm group was provided set doses of glulisine to take before each meal. The carbohydrate counting (carb count) group was provided an insulin-to-carbohydrate ratio to use for each meal and adjusted their glulisine dose based on the amount of carbohydrate consumed. RESULTS - A1C levels at week 24 were 6.70% (simple algorithm) and 6.54% (carb count). The respective mean A1C changes from baseline to 24 weeks were -1.46 and -1.59% (P = 0.24). A1C
UR - http://www.scopus.com/inward/record.url?scp=49649123535&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=49649123535&partnerID=8YFLogxK
U2 - 10.2337/dc07-2137
DO - 10.2337/dc07-2137
M3 - Article
VL - 31
SP - 1305
EP - 1310
JO - Diabetes Care
JF - Diabetes Care
SN - 1935-5548
IS - 7
ER -