Advances in the pulmonary delivery of poorly water-soluble drugs: Influence of solubilization on pharmacokinetic properties

Justin Tolman, Robert O. Williams

Research output: Contribution to journalReview article

34 Citations (Scopus)

Abstract

Background: Pulmonary drug delivery is an accepted route of drug administration for the management of lung conditions and diseases as well as an evolving route of administration for the systemic delivery of agents. Many inhaled drugs pose formulation and delivery challenges in part because of poor aqueous solubility. The influence of poor aqueous solubility and formulation-based solubility enhancements on the pharmacokinetic profile of inhaled agents was reviewed. Method: A systematic review was performed to identify literature that reported pharmacokinetic findings following the pulmonary delivery of a poorly water-soluble agent. Results: The influence of solubility and formulation-based solubility enhancements on pharmacokinetic parameters following inhalation of corticosteroids, antifungals, oligopeptides, and opioids, was compiled. Conclusion: Poor aqueous solubility did not uniformly affect the pharmacokinetic profile for inhaled agents. Physicochemical and formulation-based solubility enhancement did affect drug absorption from the lungs. Numerous drug- and formulation-dependant pharmacokinetic effects were identified.

Original languageEnglish
Pages (from-to)1-30
Number of pages30
JournalDrug Development and Industrial Pharmacy
Volume36
Issue number1
DOIs
StatePublished - Jan 2010

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Pharmacokinetics
Solubility
Lung
Water
Pharmaceutical Preparations
Drug Compounding
Drug delivery
Drug Administration Routes
Oligopeptides
Inhalation
Opioid Analgesics
Lung Diseases
Adrenal Cortex Hormones

All Science Journal Classification (ASJC) codes

  • Drug Discovery
  • Pharmacology
  • Organic Chemistry

Cite this

Advances in the pulmonary delivery of poorly water-soluble drugs : Influence of solubilization on pharmacokinetic properties. / Tolman, Justin; Williams, Robert O.

In: Drug Development and Industrial Pharmacy, Vol. 36, No. 1, 01.2010, p. 1-30.

Research output: Contribution to journalReview article

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