Age at first full-term birth and breast cancer risk in BRCA1 and BRCA2 mutation carriers

the Hereditary Breast Cancer Clinical Study Group, Joanne Kotsopoulos, Jacek Gronwald, Henry T. Lynch, Andrea Eisen, Susan L. Neuhausen, Nadine Tung, Peter Ainsworth, Jeffrey N. Weitzel, Tuya Pal, William D. Foulkes, Charis Eng, Christian F. Singer, Leigha Senter, Ping Sun, Jan Lubinski, Steven A. Narod

Research output: Contribution to journalArticle

Abstract

Purpose: In the general population, an early age at first full-term birth confers protection against the risk of developing breast cancer. The relationship between age at first birth and breast cancer risk is not clear for women with a mutation in the BRCA1 or BRCA2 gene. Thus, we undertook a case–control study of women with a BRCA1 or BRCA2 mutation to study the effects of age at first full-term birth matched for other reproductive factors. Methods: Information about reproductive factors, including age at first birth as well as medical history, was collected from a routinely administered research questionnaire. There were 2,295 matched pairs of women with a BRCA1 or BRCA2 mutation included in the final analysis. Results: There was no significant difference in the mean age at first full-term birth among the BRCA1 (24.9 vs. 25.2; P = 0.10) or BRCA2 mutation carriers (26.5 vs. 26.6 years; P = 0.80). Findings were similar in the analysis limited to cases who were diagnosed with breast cancer prior to age 45. Conclusion: This matched analysis of a large number of BRCA mutation carriers suggests that age at first birth has little influence on BRCA1 or BRCA2 breast cancer risk.

LanguageEnglish (US)
Pages1-6
Number of pages6
JournalBreast Cancer Research and Treatment
DOIs
StateAccepted/In press - May 17 2018

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Term Birth
Birth Order
Breast Neoplasms
Mutation
BRCA2 Gene
BRCA1 Gene
Age Factors
Case-Control Studies
Research
Population

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Age at first full-term birth and breast cancer risk in BRCA1 and BRCA2 mutation carriers. / the Hereditary Breast Cancer Clinical Study Group.

In: Breast Cancer Research and Treatment, 17.05.2018, p. 1-6.

Research output: Contribution to journalArticle

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abstract = "Purpose: In the general population, an early age at first full-term birth confers protection against the risk of developing breast cancer. The relationship between age at first birth and breast cancer risk is not clear for women with a mutation in the BRCA1 or BRCA2 gene. Thus, we undertook a case–control study of women with a BRCA1 or BRCA2 mutation to study the effects of age at first full-term birth matched for other reproductive factors. Methods: Information about reproductive factors, including age at first birth as well as medical history, was collected from a routinely administered research questionnaire. There were 2,295 matched pairs of women with a BRCA1 or BRCA2 mutation included in the final analysis. Results: There was no significant difference in the mean age at first full-term birth among the BRCA1 (24.9 vs. 25.2; P = 0.10) or BRCA2 mutation carriers (26.5 vs. 26.6 years; P = 0.80). Findings were similar in the analysis limited to cases who were diagnosed with breast cancer prior to age 45. Conclusion: This matched analysis of a large number of BRCA mutation carriers suggests that age at first birth has little influence on BRCA1 or BRCA2 breast cancer risk.",
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AU - Kotsopoulos, Joanne

AU - Gronwald, Jacek

AU - Lynch, Henry T.

AU - Eisen, Andrea

AU - Neuhausen, Susan L.

AU - Tung, Nadine

AU - Ainsworth, Peter

AU - Weitzel, Jeffrey N.

AU - Pal, Tuya

AU - Foulkes, William D.

AU - Eng, Charis

AU - Singer, Christian F.

AU - Senter, Leigha

AU - Sun, Ping

AU - Lubinski, Jan

AU - Narod, Steven A.

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