Abstract
Purpose: In the general population, an early age at first full-term birth confers protection against the risk of developing breast cancer. The relationship between age at first birth and breast cancer risk is not clear for women with a mutation in the BRCA1 or BRCA2 gene. Thus, we undertook a case–control study of women with a BRCA1 or BRCA2 mutation to study the effects of age at first full-term birth matched for other reproductive factors. Methods: Information about reproductive factors, including age at first birth as well as medical history, was collected from a routinely administered research questionnaire. There were 2,295 matched pairs of women with a BRCA1 or BRCA2 mutation included in the final analysis. Results: There was no significant difference in the mean age at first full-term birth among the BRCA1 (24.9 vs. 25.2; P = 0.10) or BRCA2 mutation carriers (26.5 vs. 26.6 years; P = 0.80). Findings were similar in the analysis limited to cases who were diagnosed with breast cancer prior to age 45. Conclusion: This matched analysis of a large number of BRCA mutation carriers suggests that age at first birth has little influence on BRCA1 or BRCA2 breast cancer risk.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1-6 |
| Number of pages | 6 |
| Journal | Breast Cancer Research and Treatment |
| DOIs | |
| State | Accepted/In press - May 17 2018 |
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All Science Journal Classification (ASJC) codes
- Oncology
- Cancer Research
Cite this
Age at first full-term birth and breast cancer risk in BRCA1 and BRCA2 mutation carriers. / the Hereditary Breast Cancer Clinical Study Group.
In: Breast Cancer Research and Treatment, 17.05.2018, p. 1-6.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Age at first full-term birth and breast cancer risk in BRCA1 and BRCA2 mutation carriers
AU - the Hereditary Breast Cancer Clinical Study Group
AU - Kotsopoulos, Joanne
AU - Gronwald, Jacek
AU - Lynch, Henry T.
AU - Eisen, Andrea
AU - Neuhausen, Susan L.
AU - Tung, Nadine
AU - Ainsworth, Peter
AU - Weitzel, Jeffrey N.
AU - Pal, Tuya
AU - Foulkes, William D.
AU - Eng, Charis
AU - Singer, Christian F.
AU - Senter, Leigha
AU - Sun, Ping
AU - Lubinski, Jan
AU - Narod, Steven A.
PY - 2018/5/17
Y1 - 2018/5/17
N2 - Purpose: In the general population, an early age at first full-term birth confers protection against the risk of developing breast cancer. The relationship between age at first birth and breast cancer risk is not clear for women with a mutation in the BRCA1 or BRCA2 gene. Thus, we undertook a case–control study of women with a BRCA1 or BRCA2 mutation to study the effects of age at first full-term birth matched for other reproductive factors. Methods: Information about reproductive factors, including age at first birth as well as medical history, was collected from a routinely administered research questionnaire. There were 2,295 matched pairs of women with a BRCA1 or BRCA2 mutation included in the final analysis. Results: There was no significant difference in the mean age at first full-term birth among the BRCA1 (24.9 vs. 25.2; P = 0.10) or BRCA2 mutation carriers (26.5 vs. 26.6 years; P = 0.80). Findings were similar in the analysis limited to cases who were diagnosed with breast cancer prior to age 45. Conclusion: This matched analysis of a large number of BRCA mutation carriers suggests that age at first birth has little influence on BRCA1 or BRCA2 breast cancer risk.
AB - Purpose: In the general population, an early age at first full-term birth confers protection against the risk of developing breast cancer. The relationship between age at first birth and breast cancer risk is not clear for women with a mutation in the BRCA1 or BRCA2 gene. Thus, we undertook a case–control study of women with a BRCA1 or BRCA2 mutation to study the effects of age at first full-term birth matched for other reproductive factors. Methods: Information about reproductive factors, including age at first birth as well as medical history, was collected from a routinely administered research questionnaire. There were 2,295 matched pairs of women with a BRCA1 or BRCA2 mutation included in the final analysis. Results: There was no significant difference in the mean age at first full-term birth among the BRCA1 (24.9 vs. 25.2; P = 0.10) or BRCA2 mutation carriers (26.5 vs. 26.6 years; P = 0.80). Findings were similar in the analysis limited to cases who were diagnosed with breast cancer prior to age 45. Conclusion: This matched analysis of a large number of BRCA mutation carriers suggests that age at first birth has little influence on BRCA1 or BRCA2 breast cancer risk.
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U2 - 10.1007/s10549-018-4822-y
DO - 10.1007/s10549-018-4822-y
M3 - Article
C2 - 29774471
AN - SCOPUS:85047125340
SP - 1
EP - 6
JO - Breast Cancer Research and Treatment
JF - Breast Cancer Research and Treatment
SN - 0167-6806
ER -