Age at first full-term birth and breast cancer risk in BRCA1 and BRCA2 mutation carriers

the Hereditary Breast Cancer Clinical Study Group

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Purpose: In the general population, an early age at first full-term birth confers protection against the risk of developing breast cancer. The relationship between age at first birth and breast cancer risk is not clear for women with a mutation in the BRCA1 or BRCA2 gene. Thus, we undertook a case–control study of women with a BRCA1 or BRCA2 mutation to study the effects of age at first full-term birth matched for other reproductive factors. Methods: Information about reproductive factors, including age at first birth as well as medical history, was collected from a routinely administered research questionnaire. There were 2,295 matched pairs of women with a BRCA1 or BRCA2 mutation included in the final analysis. Results: There was no significant difference in the mean age at first full-term birth among the BRCA1 (24.9 vs. 25.2; P = 0.10) or BRCA2 mutation carriers (26.5 vs. 26.6 years; P = 0.80). Findings were similar in the analysis limited to cases who were diagnosed with breast cancer prior to age 45. Conclusion: This matched analysis of a large number of BRCA mutation carriers suggests that age at first birth has little influence on BRCA1 or BRCA2 breast cancer risk.

Original languageEnglish (US)
Pages (from-to)1-6
Number of pages6
JournalBreast Cancer Research and Treatment
DOIs
StateAccepted/In press - May 17 2018

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Term Birth
Birth Order
Breast Neoplasms
Mutation
BRCA2 Gene
BRCA1 Gene
Age Factors
Research
Population

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Age at first full-term birth and breast cancer risk in BRCA1 and BRCA2 mutation carriers. / the Hereditary Breast Cancer Clinical Study Group.

In: Breast Cancer Research and Treatment, 17.05.2018, p. 1-6.

Research output: Contribution to journalArticle

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abstract = "Purpose: In the general population, an early age at first full-term birth confers protection against the risk of developing breast cancer. The relationship between age at first birth and breast cancer risk is not clear for women with a mutation in the BRCA1 or BRCA2 gene. Thus, we undertook a case–control study of women with a BRCA1 or BRCA2 mutation to study the effects of age at first full-term birth matched for other reproductive factors. Methods: Information about reproductive factors, including age at first birth as well as medical history, was collected from a routinely administered research questionnaire. There were 2,295 matched pairs of women with a BRCA1 or BRCA2 mutation included in the final analysis. Results: There was no significant difference in the mean age at first full-term birth among the BRCA1 (24.9 vs. 25.2; P = 0.10) or BRCA2 mutation carriers (26.5 vs. 26.6 years; P = 0.80). Findings were similar in the analysis limited to cases who were diagnosed with breast cancer prior to age 45. Conclusion: This matched analysis of a large number of BRCA mutation carriers suggests that age at first birth has little influence on BRCA1 or BRCA2 breast cancer risk.",
author = "{the Hereditary Breast Cancer Clinical Study Group} and Joanne Kotsopoulos and Jacek Gronwald and Lynch, {Henry T.} and Andrea Eisen and Neuhausen, {Susan L.} and Nadine Tung and Peter Ainsworth and Weitzel, {Jeffrey N.} and Tuya Pal and Foulkes, {William D.} and Charis Eng and Singer, {Christian F.} and Leigha Senter and Ping Sun and Jan Lubinski and Narod, {Steven A.}",
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AU - the Hereditary Breast Cancer Clinical Study Group

AU - Kotsopoulos, Joanne

AU - Gronwald, Jacek

AU - Lynch, Henry T.

AU - Eisen, Andrea

AU - Neuhausen, Susan L.

AU - Tung, Nadine

AU - Ainsworth, Peter

AU - Weitzel, Jeffrey N.

AU - Pal, Tuya

AU - Foulkes, William D.

AU - Eng, Charis

AU - Singer, Christian F.

AU - Senter, Leigha

AU - Sun, Ping

AU - Lubinski, Jan

AU - Narod, Steven A.

PY - 2018/5/17

Y1 - 2018/5/17

N2 - Purpose: In the general population, an early age at first full-term birth confers protection against the risk of developing breast cancer. The relationship between age at first birth and breast cancer risk is not clear for women with a mutation in the BRCA1 or BRCA2 gene. Thus, we undertook a case–control study of women with a BRCA1 or BRCA2 mutation to study the effects of age at first full-term birth matched for other reproductive factors. Methods: Information about reproductive factors, including age at first birth as well as medical history, was collected from a routinely administered research questionnaire. There were 2,295 matched pairs of women with a BRCA1 or BRCA2 mutation included in the final analysis. Results: There was no significant difference in the mean age at first full-term birth among the BRCA1 (24.9 vs. 25.2; P = 0.10) or BRCA2 mutation carriers (26.5 vs. 26.6 years; P = 0.80). Findings were similar in the analysis limited to cases who were diagnosed with breast cancer prior to age 45. Conclusion: This matched analysis of a large number of BRCA mutation carriers suggests that age at first birth has little influence on BRCA1 or BRCA2 breast cancer risk.

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