Age at first full-term birth and breast cancer risk in BRCA1 and BRCA2 mutation carriers

the Hereditary Breast Cancer Clinical Study Group

Research output: Contribution to journalArticle

4 Scopus citations


Purpose: In the general population, an early age at first full-term birth confers protection against the risk of developing breast cancer. The relationship between age at first birth and breast cancer risk is not clear for women with a mutation in the BRCA1 or BRCA2 gene. Thus, we undertook a case–control study of women with a BRCA1 or BRCA2 mutation to study the effects of age at first full-term birth matched for other reproductive factors. Methods: Information about reproductive factors, including age at first birth as well as medical history, was collected from a routinely administered research questionnaire. There were 2,295 matched pairs of women with a BRCA1 or BRCA2 mutation included in the final analysis. Results: There was no significant difference in the mean age at first full-term birth among the BRCA1 (24.9 vs. 25.2; P = 0.10) or BRCA2 mutation carriers (26.5 vs. 26.6 years; P = 0.80). Findings were similar in the analysis limited to cases who were diagnosed with breast cancer prior to age 45. Conclusion: This matched analysis of a large number of BRCA mutation carriers suggests that age at first birth has little influence on BRCA1 or BRCA2 breast cancer risk.

Original languageEnglish (US)
Pages (from-to)1-6
Number of pages6
JournalBreast Cancer Research and Treatment
StateAccepted/In press - May 17 2018


All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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