Age at onset of puberty predicts bone mass in young adulthood

Vicente Gilsanz, James Chalfant, Heidi Kalkwarf, Babette Zemel, Joan Lappe, Sharon Oberfield, John Shepherd, Tishya Wren, Karen Winer

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Abstract

Objective: To determine whether the commencement and length of puberty influences dual x-ray absorptiometry (DXA) values of bone mineral content (BMC) and bone mineral density (BMD) in the axial and appendicular skeleton at skeletal maturity. Study design: From the Bone Mineral Density in Childhood Study, we identified children who began puberty and completed sexual and skeletal development and examined whether the timing and length of puberty influence DXA values of BMC and BMD at skeletal maturity. Results: A total of 78 girls and 85 boys began puberty and completed skeletal maturity; 4.4 ± 0.8 and 4.5 ± 0.8 years later, respectively. Multiple linear regression analyses indicated that the age of onset of puberty was a strong negative predictor of DXA bone measurements at skeletal maturity, independent of bone values at the beginning of puberty, and the length of puberty. This negative relation was observed for all BMC and BMD measurements at all skeletal sites, in both boys and girls (all P <.0001). In contrast, length of puberty had no relation to any measures of bone. Conclusions: In healthy adolescent males and females, bone mass and bone density at skeletal maturity are inversely related to the timing of puberty.

Original languageEnglish (US)
Pages (from-to)100-105.e2
JournalJournal of Pediatrics
Volume158
Issue number1
DOIs
StatePublished - Jan 2011

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health

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    Gilsanz, V., Chalfant, J., Kalkwarf, H., Zemel, B., Lappe, J., Oberfield, S., Shepherd, J., Wren, T., & Winer, K. (2011). Age at onset of puberty predicts bone mass in young adulthood. Journal of Pediatrics, 158(1), 100-105.e2. https://doi.org/10.1016/j.jpeds.2010.06.054