Abstract
Objective: To determine whether the commencement and length of puberty influences dual x-ray absorptiometry (DXA) values of bone mineral content (BMC) and bone mineral density (BMD) in the axial and appendicular skeleton at skeletal maturity. Study design: From the Bone Mineral Density in Childhood Study, we identified children who began puberty and completed sexual and skeletal development and examined whether the timing and length of puberty influence DXA values of BMC and BMD at skeletal maturity. Results: A total of 78 girls and 85 boys began puberty and completed skeletal maturity; 4.4 ± 0.8 and 4.5 ± 0.8 years later, respectively. Multiple linear regression analyses indicated that the age of onset of puberty was a strong negative predictor of DXA bone measurements at skeletal maturity, independent of bone values at the beginning of puberty, and the length of puberty. This negative relation was observed for all BMC and BMD measurements at all skeletal sites, in both boys and girls (all P <.0001). In contrast, length of puberty had no relation to any measures of bone. Conclusions: In healthy adolescent males and females, bone mass and bone density at skeletal maturity are inversely related to the timing of puberty.
| Original language | English |
|---|---|
| Journal | Journal of Pediatrics |
| Volume | 158 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 2011 |
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All Science Journal Classification (ASJC) codes
- Pediatrics, Perinatology, and Child Health
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Age at onset of puberty predicts bone mass in young adulthood. / Gilsanz, Vicente; Chalfant, James; Kalkwarf, Heidi; Zemel, Babette; Lappe, Joan M.; Oberfield, Sharon; Shepherd, John; Wren, Tishya; Winer, Karen.
In: Journal of Pediatrics, Vol. 158, No. 1, 01.2011.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Age at onset of puberty predicts bone mass in young adulthood
AU - Gilsanz, Vicente
AU - Chalfant, James
AU - Kalkwarf, Heidi
AU - Zemel, Babette
AU - Lappe, Joan M.
AU - Oberfield, Sharon
AU - Shepherd, John
AU - Wren, Tishya
AU - Winer, Karen
PY - 2011/1
Y1 - 2011/1
N2 - Objective: To determine whether the commencement and length of puberty influences dual x-ray absorptiometry (DXA) values of bone mineral content (BMC) and bone mineral density (BMD) in the axial and appendicular skeleton at skeletal maturity. Study design: From the Bone Mineral Density in Childhood Study, we identified children who began puberty and completed sexual and skeletal development and examined whether the timing and length of puberty influence DXA values of BMC and BMD at skeletal maturity. Results: A total of 78 girls and 85 boys began puberty and completed skeletal maturity; 4.4 ± 0.8 and 4.5 ± 0.8 years later, respectively. Multiple linear regression analyses indicated that the age of onset of puberty was a strong negative predictor of DXA bone measurements at skeletal maturity, independent of bone values at the beginning of puberty, and the length of puberty. This negative relation was observed for all BMC and BMD measurements at all skeletal sites, in both boys and girls (all P <.0001). In contrast, length of puberty had no relation to any measures of bone. Conclusions: In healthy adolescent males and females, bone mass and bone density at skeletal maturity are inversely related to the timing of puberty.
AB - Objective: To determine whether the commencement and length of puberty influences dual x-ray absorptiometry (DXA) values of bone mineral content (BMC) and bone mineral density (BMD) in the axial and appendicular skeleton at skeletal maturity. Study design: From the Bone Mineral Density in Childhood Study, we identified children who began puberty and completed sexual and skeletal development and examined whether the timing and length of puberty influence DXA values of BMC and BMD at skeletal maturity. Results: A total of 78 girls and 85 boys began puberty and completed skeletal maturity; 4.4 ± 0.8 and 4.5 ± 0.8 years later, respectively. Multiple linear regression analyses indicated that the age of onset of puberty was a strong negative predictor of DXA bone measurements at skeletal maturity, independent of bone values at the beginning of puberty, and the length of puberty. This negative relation was observed for all BMC and BMD measurements at all skeletal sites, in both boys and girls (all P <.0001). In contrast, length of puberty had no relation to any measures of bone. Conclusions: In healthy adolescent males and females, bone mass and bone density at skeletal maturity are inversely related to the timing of puberty.
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UR - http://www.scopus.com/inward/citedby.url?scp=78649999618&partnerID=8YFLogxK
U2 - 10.1016/j.jpeds.2010.06.054
DO - 10.1016/j.jpeds.2010.06.054
M3 - Article
C2 - 20797727
AN - SCOPUS:78649999618
VL - 158
JO - Journal of Pediatrics
JF - Journal of Pediatrics
SN - 0022-3476
IS - 1
ER -