Age-based reference ranges for annual height velocity in US children

Andrea Kelly, Karen K. Winer, Heidi Kalkwarf, Sharon E. Oberfield, Joan M. Lappe, Vicente Gilsanz, Babette S. Zemel

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Objective: Clinicians caring for children rely on measures of linear growth as a biomarker of development and overall health. Current reference ranges for height velocity (HV) for US children are unable to provide HV percentiles or Z-scores for early maturing and late maturing children at ages other than age at peak velocity. We present empirically acquired, age-specific reference ranges for HV from a contemporary sample of US youth. Study Design: Subjects were enrolled in the Bone Mineral Density in Childhood Study, a large, multicenter, multiethnic, contemporary cohort of children (aged 5-19 y at enrollment) from the United States followed for up to 7 years. More than 4000 annual (12 ± 1 mo) HV measurements from approximately 1500 children were available. Pubertal status was determined by breast stage or testicular volume assessed by experienced health providers. Age-specific reference ranges were determined using the LMS method. Results: Reference ranges (third to 97th percentiles) were generated for the entire cohort and for subgroups whose pubertal timing was defined as "earlier," "average," or "later." African American girls experienced earlier pubertal onset and had greater HV at younger ages and lower HV at older ages, compared to non-African American girls; differences did not persist after adjustment for pubertal timing. These differences were not observed for males. Conclusions: These reference ranges for annual HV can be used to assess growth relative to peers of the same age and sex, with consideration of pubertal timing. Z-scores and exact percentiles for HV can also be determined for population studies.

Original languageEnglish
Pages (from-to)2104-2112
Number of pages9
JournalJournal of Clinical Endocrinology and Metabolism
Volume99
Issue number6
DOIs
StatePublished - 2014

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Reference Values
Health
Growth
African Americans
Bone Density
Breast
Biomarkers
Velocity measurement
Minerals
Bone
Population

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Clinical Biochemistry
  • Endocrinology
  • Biochemistry, medical
  • Endocrinology, Diabetes and Metabolism

Cite this

Kelly, A., Winer, K. K., Kalkwarf, H., Oberfield, S. E., Lappe, J. M., Gilsanz, V., & Zemel, B. S. (2014). Age-based reference ranges for annual height velocity in US children. Journal of Clinical Endocrinology and Metabolism, 99(6), 2104-2112. https://doi.org/10.1210/jc.2013-4455

Age-based reference ranges for annual height velocity in US children. / Kelly, Andrea; Winer, Karen K.; Kalkwarf, Heidi; Oberfield, Sharon E.; Lappe, Joan M.; Gilsanz, Vicente; Zemel, Babette S.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 99, No. 6, 2014, p. 2104-2112.

Research output: Contribution to journalArticle

Kelly, A, Winer, KK, Kalkwarf, H, Oberfield, SE, Lappe, JM, Gilsanz, V & Zemel, BS 2014, 'Age-based reference ranges for annual height velocity in US children', Journal of Clinical Endocrinology and Metabolism, vol. 99, no. 6, pp. 2104-2112. https://doi.org/10.1210/jc.2013-4455
Kelly, Andrea ; Winer, Karen K. ; Kalkwarf, Heidi ; Oberfield, Sharon E. ; Lappe, Joan M. ; Gilsanz, Vicente ; Zemel, Babette S. / Age-based reference ranges for annual height velocity in US children. In: Journal of Clinical Endocrinology and Metabolism. 2014 ; Vol. 99, No. 6. pp. 2104-2112.
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