Abstract
Knowledge of the family history of cancer may significantly influence diagnosis and surgical management. Hereditary breast cancer (HBC) is common and accounts for approximately 9% of the total breast cancer burden. The pattern of HBC's natural history, including age of onset, increased incidence of bilaterality, integral tumor combinations in certain kindreds, and vertical transmission consonant with an autosomal dominantly inherited factor, when observed in context with the family history, enables pattern recognition so that the diagnosis might be facilitated. We describe seven families from our Hereditary Cancer Consultation Center (HCCC) and the Creighton Oncology Clinic which are noteworthy for extraordinarily early age of onset. This appears to be an additional example of heterogeneity in HBC and may represent the first account of this remarkable subset. The manner in which age of onset can be incorporated with other aspects of natural history for expediting diagnosis is discussed.
| Original language | English |
|---|---|
| Pages (from-to) | 275-285 |
| Number of pages | 11 |
| Journal | Breast Cancer Research and Treatment |
| Volume | 12 |
| Issue number | 3 |
| DOIs | |
| State | Published - Dec 1988 |
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All Science Journal Classification (ASJC) codes
- Oncology
- Cancer Research
Cite this
Age-of-onset heterogeneity in hereditary breast cancer : Minimal clues for diagnosis. / Lynch, Henry T.; Conway, Theresa; Fitzgibbons, Robert Joseph; Schreiman, Judith; Watson, Patrice; Marcus, Joseph; Fitzsimmons, Mary Lee; Lynch, Jane F.
In: Breast Cancer Research and Treatment, Vol. 12, No. 3, 12.1988, p. 275-285.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Age-of-onset heterogeneity in hereditary breast cancer
T2 - Minimal clues for diagnosis
AU - Lynch, Henry T.
AU - Conway, Theresa
AU - Fitzgibbons, Robert Joseph
AU - Schreiman, Judith
AU - Watson, Patrice
AU - Marcus, Joseph
AU - Fitzsimmons, Mary Lee
AU - Lynch, Jane F.
PY - 1988/12
Y1 - 1988/12
N2 - Knowledge of the family history of cancer may significantly influence diagnosis and surgical management. Hereditary breast cancer (HBC) is common and accounts for approximately 9% of the total breast cancer burden. The pattern of HBC's natural history, including age of onset, increased incidence of bilaterality, integral tumor combinations in certain kindreds, and vertical transmission consonant with an autosomal dominantly inherited factor, when observed in context with the family history, enables pattern recognition so that the diagnosis might be facilitated. We describe seven families from our Hereditary Cancer Consultation Center (HCCC) and the Creighton Oncology Clinic which are noteworthy for extraordinarily early age of onset. This appears to be an additional example of heterogeneity in HBC and may represent the first account of this remarkable subset. The manner in which age of onset can be incorporated with other aspects of natural history for expediting diagnosis is discussed.
AB - Knowledge of the family history of cancer may significantly influence diagnosis and surgical management. Hereditary breast cancer (HBC) is common and accounts for approximately 9% of the total breast cancer burden. The pattern of HBC's natural history, including age of onset, increased incidence of bilaterality, integral tumor combinations in certain kindreds, and vertical transmission consonant with an autosomal dominantly inherited factor, when observed in context with the family history, enables pattern recognition so that the diagnosis might be facilitated. We describe seven families from our Hereditary Cancer Consultation Center (HCCC) and the Creighton Oncology Clinic which are noteworthy for extraordinarily early age of onset. This appears to be an additional example of heterogeneity in HBC and may represent the first account of this remarkable subset. The manner in which age of onset can be incorporated with other aspects of natural history for expediting diagnosis is discussed.
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UR - http://www.scopus.com/inward/citedby.url?scp=0024212483&partnerID=8YFLogxK
U2 - 10.1007/BF01811240
DO - 10.1007/BF01811240
M3 - Article
VL - 12
SP - 275
EP - 285
JO - Breast Cancer Research and Treatment
JF - Breast Cancer Research and Treatment
SN - 0167-6806
IS - 3
ER -