Age-race subgroup compared with renin profile as predictors of blood pressure response to antihypertensive therapy

Richard A. Preston, Barry J. Materson, Domenic J. Reda, David W. Williams, Robert J. Hamburger, William C. Cushman, Robert J. Anderson

Research output: Contribution to journalArticle

146 Scopus citations


Context. - Renin profiling and age-race subgroup may help select single- drug therapy for stage 1 and stage 2 hypertension. Objective. - To compare the plasma renin profiling and age-race subgroup methods as predictors of response to single-drug therapy in men with stage 1 and 2 hypertension as defined by the Joint National Committee on Prevention, Detection, Evaluation and Treatment of High Blood Pressure. Design. - The Veterans Affairs Cooperative on Single-Drug Therapy of Hypertension, a randomized controlled trial. Setting. - Fifteen Veterans Affairs hypertension centers. Patients. - A total of 1105 ambulatory men with entry diastolic blood pressure (DBP) of 95 to 109 mm Hg, of whom 1031 had valid plasma and urine samples for renin profiling. Interventions. - Randomization to 1 of 6 antihypertensive drugs: hydrochlorothiazide, atenolol, captopril, clonidine, diltiazem (sustained release), or prazosin. Main Outcome Measure. - Treatment response as assessed by percentage achieving goal DBP (

Original languageEnglish (US)
Pages (from-to)1168-1172
Number of pages5
JournalJournal of the American Medical Association
Issue number13
StatePublished - Oct 7 1998
Externally publishedYes


All Science Journal Classification (ASJC) codes

  • Medicine(all)

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