Age-related change in parathyroid hormone-dependent cyclic AMP formation in rat kidney

Robert Marcus, David Gonzales

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Parathyroid hormone (PTH) dependent cyclic AMP (cAMP) accumulation was evaluated in renal cortex from 2- and 12-month-old rats. Basal cAMP was lower, and responses to PTH were greater at all concentrations of hormone in kidney from 2-month-old rats. This difference was obliterated by prior removal of parathyroid glands, cAMP responses to calcitonin and both basal and hormone-stimulated adenylate cyclase activity were the same at both ages. The results suggest progressive loss of responsiveness to PTH with age, but at a site other than the receptor-adenylate cyclase complex. Blunted cAMP accumulation in year-old rats most likely reflects agonist-specific desensitization.

Original languageEnglish (US)
Pages (from-to)353-360
Number of pages8
JournalMechanisms of Ageing and Development
Volume20
Issue number4
DOIs
StatePublished - Dec 1982
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Aging
  • Developmental Biology

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