Abstract
Parathyroid hormone (PTH) dependent cyclic AMP (cAMP) accumulation was evaluated in renal cortex from 2- and 12-month-old rats. Basal cAMP was lower, and responses to PTH were greater at all concentrations of hormone in kidney from 2-month-old rats. This difference was obliterated by prior removal of parathyroid glands, cAMP responses to calcitonin and both basal and hormone-stimulated adenylate cyclase activity were the same at both ages. The results suggest progressive loss of responsiveness to PTH with age, but at a site other than the receptor-adenylate cyclase complex. Blunted cAMP accumulation in year-old rats most likely reflects agonist-specific desensitization.
Original language | English (US) |
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Pages (from-to) | 353-360 |
Number of pages | 8 |
Journal | Mechanisms of Ageing and Development |
Volume | 20 |
Issue number | 4 |
DOIs | |
State | Published - Dec 1982 |
Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Aging
- Developmental Biology