Age-related periodontitis and alveolar bone loss in rice rats

J. I. Aguirre, Mohammed P. Akhter, K. G. Neuville, C. R. Trcalek, A. M. Leeper, A. A. Williams, M. Rivera, L. Kesavalu, H. Z. Ke, M. Liu, D. B. Kimmel

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Abstract

Objective To characterize in rice rats: (a) periodontitis (PD) progress with feeding of standard laboratory rat chow (STD) during ages 4–80 weeks; and (b) PD progress with feeding of a high sucrose-casein (H-SC) diet during young adulthood. Methods One group (N = 12) was euthanized at age 4 weeks (Baseline). Four groups (N = 8-16) consumed a STD diet from baseline and were necropsied at ages 22, 30, 52, and 80 weeks. Three groups (N = 10-16) consumed an H-SC diet from baseline. Two were necropsied at ages 22 and 30 weeks, respectively. The third switched to the STD diet at age 22 weeks and was necropsied at age 30 weeks. All mandibles/maxillae were assessed by histometry for degree of periodontal inflammation (PD Score), alveolar crest height (ACH, mm), and horizontal alveolar bone height (hABH, mm2). Results In STD diet rats aged ≥30 weeks, all endpoints were worse (P < 0.05) than at Baseline. In H-SC diet rats aged ≥22 weeks, all endpoints were worse than at Baseline (P < 0.05). At age 22 weeks, all endpoints were worse in the H-SC group than in the STD group (P < 0.05). By age 30 weeks, the STD and H-SC groups did not differ. Conclusions 1) STD diet fed rice rats develop moderate/severe PD by age 30 weeks; 2) an H-SC diet accelerates moderate/severe PD development; and 3) switching to a STD diet does not halt/reverse PD that was accelerated by an H-SC diet. These data further clarify use of the rice rat as a PD model.

Original languageEnglish (US)
Pages (from-to)193-205
Number of pages13
JournalArchives of Oral Biology
Volume73
DOIs
StatePublished - Jan 1 2017

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Sigmodontinae
Alveolar Bone Loss
Periodontitis
Osteoporosis
Sexually Transmitted Diseases
Caseins
Diet
Sucrose
Maxilla
Mandible

All Science Journal Classification (ASJC) codes

  • Otorhinolaryngology
  • Dentistry(all)
  • Cell Biology

Cite this

Aguirre, J. I., Akhter, M. P., Neuville, K. G., Trcalek, C. R., Leeper, A. M., Williams, A. A., ... Kimmel, D. B. (2017). Age-related periodontitis and alveolar bone loss in rice rats. Archives of Oral Biology, 73, 193-205. https://doi.org/10.1016/j.archoralbio.2016.10.018

Age-related periodontitis and alveolar bone loss in rice rats. / Aguirre, J. I.; Akhter, Mohammed P.; Neuville, K. G.; Trcalek, C. R.; Leeper, A. M.; Williams, A. A.; Rivera, M.; Kesavalu, L.; Ke, H. Z.; Liu, M.; Kimmel, D. B.

In: Archives of Oral Biology, Vol. 73, 01.01.2017, p. 193-205.

Research output: Contribution to journalArticle

Aguirre, JI, Akhter, MP, Neuville, KG, Trcalek, CR, Leeper, AM, Williams, AA, Rivera, M, Kesavalu, L, Ke, HZ, Liu, M & Kimmel, DB 2017, 'Age-related periodontitis and alveolar bone loss in rice rats', Archives of Oral Biology, vol. 73, pp. 193-205. https://doi.org/10.1016/j.archoralbio.2016.10.018
Aguirre, J. I. ; Akhter, Mohammed P. ; Neuville, K. G. ; Trcalek, C. R. ; Leeper, A. M. ; Williams, A. A. ; Rivera, M. ; Kesavalu, L. ; Ke, H. Z. ; Liu, M. ; Kimmel, D. B. / Age-related periodontitis and alveolar bone loss in rice rats. In: Archives of Oral Biology. 2017 ; Vol. 73. pp. 193-205.
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abstract = "Objective To characterize in rice rats: (a) periodontitis (PD) progress with feeding of standard laboratory rat chow (STD) during ages 4–80 weeks; and (b) PD progress with feeding of a high sucrose-casein (H-SC) diet during young adulthood. Methods One group (N = 12) was euthanized at age 4 weeks (Baseline). Four groups (N = 8-16) consumed a STD diet from baseline and were necropsied at ages 22, 30, 52, and 80 weeks. Three groups (N = 10-16) consumed an H-SC diet from baseline. Two were necropsied at ages 22 and 30 weeks, respectively. The third switched to the STD diet at age 22 weeks and was necropsied at age 30 weeks. All mandibles/maxillae were assessed by histometry for degree of periodontal inflammation (PD Score), alveolar crest height (ACH, mm), and horizontal alveolar bone height (hABH, mm2). Results In STD diet rats aged ≥30 weeks, all endpoints were worse (P < 0.05) than at Baseline. In H-SC diet rats aged ≥22 weeks, all endpoints were worse than at Baseline (P < 0.05). At age 22 weeks, all endpoints were worse in the H-SC group than in the STD group (P < 0.05). By age 30 weeks, the STD and H-SC groups did not differ. Conclusions 1) STD diet fed rice rats develop moderate/severe PD by age 30 weeks; 2) an H-SC diet accelerates moderate/severe PD development; and 3) switching to a STD diet does not halt/reverse PD that was accelerated by an H-SC diet. These data further clarify use of the rice rat as a PD model.",
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AU - Akhter, Mohammed P.

AU - Neuville, K. G.

AU - Trcalek, C. R.

AU - Leeper, A. M.

AU - Williams, A. A.

AU - Rivera, M.

AU - Kesavalu, L.

AU - Ke, H. Z.

AU - Liu, M.

AU - Kimmel, D. B.

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N2 - Objective To characterize in rice rats: (a) periodontitis (PD) progress with feeding of standard laboratory rat chow (STD) during ages 4–80 weeks; and (b) PD progress with feeding of a high sucrose-casein (H-SC) diet during young adulthood. Methods One group (N = 12) was euthanized at age 4 weeks (Baseline). Four groups (N = 8-16) consumed a STD diet from baseline and were necropsied at ages 22, 30, 52, and 80 weeks. Three groups (N = 10-16) consumed an H-SC diet from baseline. Two were necropsied at ages 22 and 30 weeks, respectively. The third switched to the STD diet at age 22 weeks and was necropsied at age 30 weeks. All mandibles/maxillae were assessed by histometry for degree of periodontal inflammation (PD Score), alveolar crest height (ACH, mm), and horizontal alveolar bone height (hABH, mm2). Results In STD diet rats aged ≥30 weeks, all endpoints were worse (P < 0.05) than at Baseline. In H-SC diet rats aged ≥22 weeks, all endpoints were worse than at Baseline (P < 0.05). At age 22 weeks, all endpoints were worse in the H-SC group than in the STD group (P < 0.05). By age 30 weeks, the STD and H-SC groups did not differ. Conclusions 1) STD diet fed rice rats develop moderate/severe PD by age 30 weeks; 2) an H-SC diet accelerates moderate/severe PD development; and 3) switching to a STD diet does not halt/reverse PD that was accelerated by an H-SC diet. These data further clarify use of the rice rat as a PD model.

AB - Objective To characterize in rice rats: (a) periodontitis (PD) progress with feeding of standard laboratory rat chow (STD) during ages 4–80 weeks; and (b) PD progress with feeding of a high sucrose-casein (H-SC) diet during young adulthood. Methods One group (N = 12) was euthanized at age 4 weeks (Baseline). Four groups (N = 8-16) consumed a STD diet from baseline and were necropsied at ages 22, 30, 52, and 80 weeks. Three groups (N = 10-16) consumed an H-SC diet from baseline. Two were necropsied at ages 22 and 30 weeks, respectively. The third switched to the STD diet at age 22 weeks and was necropsied at age 30 weeks. All mandibles/maxillae were assessed by histometry for degree of periodontal inflammation (PD Score), alveolar crest height (ACH, mm), and horizontal alveolar bone height (hABH, mm2). Results In STD diet rats aged ≥30 weeks, all endpoints were worse (P < 0.05) than at Baseline. In H-SC diet rats aged ≥22 weeks, all endpoints were worse than at Baseline (P < 0.05). At age 22 weeks, all endpoints were worse in the H-SC group than in the STD group (P < 0.05). By age 30 weeks, the STD and H-SC groups did not differ. Conclusions 1) STD diet fed rice rats develop moderate/severe PD by age 30 weeks; 2) an H-SC diet accelerates moderate/severe PD development; and 3) switching to a STD diet does not halt/reverse PD that was accelerated by an H-SC diet. These data further clarify use of the rice rat as a PD model.

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