Aggravation of exercise performance in patients with anemia by 3% carboxyhemoglobin

Wilbert S. Aronow, William J. Schlueter, Mark A. Williams, Marlene Petratis, Michael H. Sketch

Research output: Contribution to journalArticle

Abstract

To evaluate the effect of breathing 50 ppm carbon monoxide (CO) on exercise capacity in persons with anemia, 10 nonsmoking subjects with chronic anemia (mean hemoglobin 8.9 g%) were studied. No subject had heart or lung disease. By double-blind, randomized, crossover design, duration of fatigue-limited exercise after breathing CO and purified air for 1 hr was compared. Mean carboxyhemoglobin levels increased from 2.14 to 3.38% after breathing CO and decreased from 2.15 to 1.86% after breathing purified air, P < 0.004. Mean exercise duration decreased from 270.8 to 221.0 sec after breathing CO in contrast to an increase from 267.9 to 271.6 sec after breathing purified air, P < 0.0001. Hence, in the absence of clinical heart or lung disease, increasing carboxyhemoglobin concentrations aggravate exercise performance in nonsmokers with chronic anemia.

Original languageEnglish (US)
Pages (from-to)394-398
Number of pages5
JournalEnvironmental Research
Volume35
Issue number2
DOIs
Publication statusPublished - Dec 1984
Externally publishedYes

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All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Environmental Science(all)

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