TY - JOUR
T1 - Aggregated N-of-1 randomized controlled trials
T2 - Modern data analytics applied to a clinically valid method of intervention effectiveness
AU - Cushing, Christopher C.
AU - Walters, Ryan W.
AU - Hoffman, Lesa
PY - 2014/3
Y1 - 2014/3
N2 - Objective Aggregated N-of-1 randomized controlled trials (RCTs) combined with multilevel modeling represent a methodological advancement that may help bridge science and practice in pediatric psychology. The purpose of this article is to offer a primer for pediatric psychologists interested in conducting aggregated N-of-1 RCTs. Methods An overview of N-of-1 RCT methodology is provided and 2 simulated data sets are analyzed to demonstrate the clinical and research potential of the methodology. Results The simulated data example demonstrates the utility of aggregated N-of-1 RCTs for understanding the clinical impact of an intervention for a given individual and the modeling of covariates to explain why an intervention worked for one patient and not another. Conclusions Aggregated N-of-1 RCTs hold potential for improving the science and practice of pediatric psychology.
AB - Objective Aggregated N-of-1 randomized controlled trials (RCTs) combined with multilevel modeling represent a methodological advancement that may help bridge science and practice in pediatric psychology. The purpose of this article is to offer a primer for pediatric psychologists interested in conducting aggregated N-of-1 RCTs. Methods An overview of N-of-1 RCT methodology is provided and 2 simulated data sets are analyzed to demonstrate the clinical and research potential of the methodology. Results The simulated data example demonstrates the utility of aggregated N-of-1 RCTs for understanding the clinical impact of an intervention for a given individual and the modeling of covariates to explain why an intervention worked for one patient and not another. Conclusions Aggregated N-of-1 RCTs hold potential for improving the science and practice of pediatric psychology.
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U2 - 10.1093/jpepsy/jst083
DO - 10.1093/jpepsy/jst083
M3 - Article
C2 - 24284134
AN - SCOPUS:84897764695
VL - 39
SP - 138
EP - 150
JO - Journal of Pediatric Psychology
JF - Journal of Pediatric Psychology
SN - 0146-8693
IS - 2
ER -