Abstract
SJL/J lymphomas emerged as H-2D(s)-negative variants upon transplantation of their respective H-2D(s)-positive spontaneous tumors. Of nine spontaneous SJL/J lymphomas examined, only two contained detectable numbers of H-2D(s)-negative tumor cells. Of seven successfully transplanted tumors, however, four emerged as predominantly H-2D(s)-negative tumors by their second transplantation. Long term SJL/J lymphoma lines, RCS 5 and SJL/SJL, were also found to be H-2D(s)-negative. The expression of H-2K(s) and I-A(s) were maintained on all tumor lines examined. H-2D(s)-negative tumor cells were consistent stimulators of syngeneic lymphoproliferation, whereas tumors maintaining H-2D(s) expression varied in their stimulatory capacity. Transplantation times required to achieve morbidity in syngeneic mice correlated with tumor cell expression of H-2D(s). Tumors maintaining H-2D(s) expression were less aggressive and required 57 to 150 days to produce morbidity compared with highly aggressive H-2D(s)-negative tumors that required only 7 to 10 days at one-quarter of the cell dose (107 cells). Growth curve analysis based on spleen weights (corrected for body weight) indicated that three types of SJL/J lymphomas could be identified based on their expression of H-2D(s) and ability to stimulate syngeneic lymphoproliferation: 1) indolent, nonstimulatory H-2D(s)-positive tumors; 2) indolent, stimulatory H-2D(s)-positive tumors; and 3) highly aggressive, stimulatory H-2D(s)-negative tumors.
| Original language | English |
|---|---|
| Pages (from-to) | 945-952 |
| Number of pages | 8 |
| Journal | Journal of Immunology |
| Volume | 132 |
| Issue number | 2 |
| State | Published - 1984 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Immunology
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Aggressiveness of SJL/J lymphomas correlates with absence of H-2D(s) antigens. / Rosloniec, E. F.; Kuhn, M. H.; Genyea, C. A.; Reed, A. H.; Jennings, J. J.; Giraldo, A. A.; Beisel, Kirk; Lerman, S. P.
In: Journal of Immunology, Vol. 132, No. 2, 1984, p. 945-952.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Aggressiveness of SJL/J lymphomas correlates with absence of H-2D(s) antigens
AU - Rosloniec, E. F.
AU - Kuhn, M. H.
AU - Genyea, C. A.
AU - Reed, A. H.
AU - Jennings, J. J.
AU - Giraldo, A. A.
AU - Beisel, Kirk
AU - Lerman, S. P.
PY - 1984
Y1 - 1984
N2 - SJL/J lymphomas emerged as H-2D(s)-negative variants upon transplantation of their respective H-2D(s)-positive spontaneous tumors. Of nine spontaneous SJL/J lymphomas examined, only two contained detectable numbers of H-2D(s)-negative tumor cells. Of seven successfully transplanted tumors, however, four emerged as predominantly H-2D(s)-negative tumors by their second transplantation. Long term SJL/J lymphoma lines, RCS 5 and SJL/SJL, were also found to be H-2D(s)-negative. The expression of H-2K(s) and I-A(s) were maintained on all tumor lines examined. H-2D(s)-negative tumor cells were consistent stimulators of syngeneic lymphoproliferation, whereas tumors maintaining H-2D(s) expression varied in their stimulatory capacity. Transplantation times required to achieve morbidity in syngeneic mice correlated with tumor cell expression of H-2D(s). Tumors maintaining H-2D(s) expression were less aggressive and required 57 to 150 days to produce morbidity compared with highly aggressive H-2D(s)-negative tumors that required only 7 to 10 days at one-quarter of the cell dose (107 cells). Growth curve analysis based on spleen weights (corrected for body weight) indicated that three types of SJL/J lymphomas could be identified based on their expression of H-2D(s) and ability to stimulate syngeneic lymphoproliferation: 1) indolent, nonstimulatory H-2D(s)-positive tumors; 2) indolent, stimulatory H-2D(s)-positive tumors; and 3) highly aggressive, stimulatory H-2D(s)-negative tumors.
AB - SJL/J lymphomas emerged as H-2D(s)-negative variants upon transplantation of their respective H-2D(s)-positive spontaneous tumors. Of nine spontaneous SJL/J lymphomas examined, only two contained detectable numbers of H-2D(s)-negative tumor cells. Of seven successfully transplanted tumors, however, four emerged as predominantly H-2D(s)-negative tumors by their second transplantation. Long term SJL/J lymphoma lines, RCS 5 and SJL/SJL, were also found to be H-2D(s)-negative. The expression of H-2K(s) and I-A(s) were maintained on all tumor lines examined. H-2D(s)-negative tumor cells were consistent stimulators of syngeneic lymphoproliferation, whereas tumors maintaining H-2D(s) expression varied in their stimulatory capacity. Transplantation times required to achieve morbidity in syngeneic mice correlated with tumor cell expression of H-2D(s). Tumors maintaining H-2D(s) expression were less aggressive and required 57 to 150 days to produce morbidity compared with highly aggressive H-2D(s)-negative tumors that required only 7 to 10 days at one-quarter of the cell dose (107 cells). Growth curve analysis based on spleen weights (corrected for body weight) indicated that three types of SJL/J lymphomas could be identified based on their expression of H-2D(s) and ability to stimulate syngeneic lymphoproliferation: 1) indolent, nonstimulatory H-2D(s)-positive tumors; 2) indolent, stimulatory H-2D(s)-positive tumors; and 3) highly aggressive, stimulatory H-2D(s)-negative tumors.
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M3 - Article
C2 - 6606680
AN - SCOPUS:0021322742
VL - 132
SP - 945
EP - 952
JO - Journal of Immunology
JF - Journal of Immunology
SN - 0022-1767
IS - 2
ER -