Aggressiveness of SJL/J lymphomas correlates with absence of H-2D(s) antigens

E. F. Rosloniec, M. H. Kuhn, C. A. Genyea, A. H. Reed, J. J. Jennings, A. A. Giraldo, Kirk Beisel, S. P. Lerman

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Abstract

SJL/J lymphomas emerged as H-2D(s)-negative variants upon transplantation of their respective H-2D(s)-positive spontaneous tumors. Of nine spontaneous SJL/J lymphomas examined, only two contained detectable numbers of H-2D(s)-negative tumor cells. Of seven successfully transplanted tumors, however, four emerged as predominantly H-2D(s)-negative tumors by their second transplantation. Long term SJL/J lymphoma lines, RCS 5 and SJL/SJL, were also found to be H-2D(s)-negative. The expression of H-2K(s) and I-A(s) were maintained on all tumor lines examined. H-2D(s)-negative tumor cells were consistent stimulators of syngeneic lymphoproliferation, whereas tumors maintaining H-2D(s) expression varied in their stimulatory capacity. Transplantation times required to achieve morbidity in syngeneic mice correlated with tumor cell expression of H-2D(s). Tumors maintaining H-2D(s) expression were less aggressive and required 57 to 150 days to produce morbidity compared with highly aggressive H-2D(s)-negative tumors that required only 7 to 10 days at one-quarter of the cell dose (107 cells). Growth curve analysis based on spleen weights (corrected for body weight) indicated that three types of SJL/J lymphomas could be identified based on their expression of H-2D(s) and ability to stimulate syngeneic lymphoproliferation: 1) indolent, nonstimulatory H-2D(s)-positive tumors; 2) indolent, stimulatory H-2D(s)-positive tumors; and 3) highly aggressive, stimulatory H-2D(s)-negative tumors.

Original languageEnglish
Pages (from-to)945-952
Number of pages8
JournalJournal of Immunology
Volume132
Issue number2
StatePublished - 1984
Externally publishedYes

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Lymphoma
Antigens
Neoplasms
Transplantation
Morbidity
Spleen
Body Weight
Weights and Measures

All Science Journal Classification (ASJC) codes

  • Immunology

Cite this

Rosloniec, E. F., Kuhn, M. H., Genyea, C. A., Reed, A. H., Jennings, J. J., Giraldo, A. A., ... Lerman, S. P. (1984). Aggressiveness of SJL/J lymphomas correlates with absence of H-2D(s) antigens. Journal of Immunology, 132(2), 945-952.

Aggressiveness of SJL/J lymphomas correlates with absence of H-2D(s) antigens. / Rosloniec, E. F.; Kuhn, M. H.; Genyea, C. A.; Reed, A. H.; Jennings, J. J.; Giraldo, A. A.; Beisel, Kirk; Lerman, S. P.

In: Journal of Immunology, Vol. 132, No. 2, 1984, p. 945-952.

Research output: Contribution to journalArticle

Rosloniec, EF, Kuhn, MH, Genyea, CA, Reed, AH, Jennings, JJ, Giraldo, AA, Beisel, K & Lerman, SP 1984, 'Aggressiveness of SJL/J lymphomas correlates with absence of H-2D(s) antigens', Journal of Immunology, vol. 132, no. 2, pp. 945-952.
Rosloniec EF, Kuhn MH, Genyea CA, Reed AH, Jennings JJ, Giraldo AA et al. Aggressiveness of SJL/J lymphomas correlates with absence of H-2D(s) antigens. Journal of Immunology. 1984;132(2):945-952.
Rosloniec, E. F. ; Kuhn, M. H. ; Genyea, C. A. ; Reed, A. H. ; Jennings, J. J. ; Giraldo, A. A. ; Beisel, Kirk ; Lerman, S. P. / Aggressiveness of SJL/J lymphomas correlates with absence of H-2D(s) antigens. In: Journal of Immunology. 1984 ; Vol. 132, No. 2. pp. 945-952.
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abstract = "SJL/J lymphomas emerged as H-2D(s)-negative variants upon transplantation of their respective H-2D(s)-positive spontaneous tumors. Of nine spontaneous SJL/J lymphomas examined, only two contained detectable numbers of H-2D(s)-negative tumor cells. Of seven successfully transplanted tumors, however, four emerged as predominantly H-2D(s)-negative tumors by their second transplantation. Long term SJL/J lymphoma lines, RCS 5 and SJL/SJL, were also found to be H-2D(s)-negative. The expression of H-2K(s) and I-A(s) were maintained on all tumor lines examined. H-2D(s)-negative tumor cells were consistent stimulators of syngeneic lymphoproliferation, whereas tumors maintaining H-2D(s) expression varied in their stimulatory capacity. Transplantation times required to achieve morbidity in syngeneic mice correlated with tumor cell expression of H-2D(s). Tumors maintaining H-2D(s) expression were less aggressive and required 57 to 150 days to produce morbidity compared with highly aggressive H-2D(s)-negative tumors that required only 7 to 10 days at one-quarter of the cell dose (107 cells). Growth curve analysis based on spleen weights (corrected for body weight) indicated that three types of SJL/J lymphomas could be identified based on their expression of H-2D(s) and ability to stimulate syngeneic lymphoproliferation: 1) indolent, nonstimulatory H-2D(s)-positive tumors; 2) indolent, stimulatory H-2D(s)-positive tumors; and 3) highly aggressive, stimulatory H-2D(s)-negative tumors.",
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AU - Rosloniec, E. F.

AU - Kuhn, M. H.

AU - Genyea, C. A.

AU - Reed, A. H.

AU - Jennings, J. J.

AU - Giraldo, A. A.

AU - Beisel, Kirk

AU - Lerman, S. P.

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AB - SJL/J lymphomas emerged as H-2D(s)-negative variants upon transplantation of their respective H-2D(s)-positive spontaneous tumors. Of nine spontaneous SJL/J lymphomas examined, only two contained detectable numbers of H-2D(s)-negative tumor cells. Of seven successfully transplanted tumors, however, four emerged as predominantly H-2D(s)-negative tumors by their second transplantation. Long term SJL/J lymphoma lines, RCS 5 and SJL/SJL, were also found to be H-2D(s)-negative. The expression of H-2K(s) and I-A(s) were maintained on all tumor lines examined. H-2D(s)-negative tumor cells were consistent stimulators of syngeneic lymphoproliferation, whereas tumors maintaining H-2D(s) expression varied in their stimulatory capacity. Transplantation times required to achieve morbidity in syngeneic mice correlated with tumor cell expression of H-2D(s). Tumors maintaining H-2D(s) expression were less aggressive and required 57 to 150 days to produce morbidity compared with highly aggressive H-2D(s)-negative tumors that required only 7 to 10 days at one-quarter of the cell dose (107 cells). Growth curve analysis based on spleen weights (corrected for body weight) indicated that three types of SJL/J lymphomas could be identified based on their expression of H-2D(s) and ability to stimulate syngeneic lymphoproliferation: 1) indolent, nonstimulatory H-2D(s)-positive tumors; 2) indolent, stimulatory H-2D(s)-positive tumors; and 3) highly aggressive, stimulatory H-2D(s)-negative tumors.

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