Abstract
-The CA1 and CA4/area dentata subfields of the hippocampus in young, mature and old rats were examined for age-related change in propyl β-carboline-3-carboxylate (PrCC) binding. 3H-PrCC bound with high affinity (Kd=0.82 nM) to one binding site when ethyl β-carboline-3-carboxylate was used to delineate specific binding. An age dependent change in the maximum number of 3H-PrCC binding sites in the CA1 and CA4/area dentate subfields of the hippocampus were assessed by using a saturating (6 nM) concentration of 3H-PrCC. Although 3H-PrCC specific binding at a saturating concentration (6 nM) was significantly less in both the CA1 and CA4/area dentata subfields of the senescent rat, the magnitude of the decrease was greater in the CA1 region. In addition, the affinity of the 3H-PrCC binding site in both subfields probably did not vary significantly with age. Therefore, the CA1 and CA4/area dentate of the rat hippocampus may not only lose BZ1 receptors or the BZ1 receptors conformation with age, but the severity of receptor or receptor conformation loss varies with the subfield.
| Original language | English |
|---|---|
| Pages (from-to) | 49-53 |
| Number of pages | 5 |
| Journal | Neurobiology of Aging |
| Volume | 5 |
| Issue number | 1 |
| DOIs | |
| State | Published - 1984 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Clinical Neurology
- Biological Psychiatry
- Developmental Neuroscience
- Neurology
- Psychology(all)
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Aging : Effects on β-carboline binding in hippocampal subfields. / Zobrist, R. H.; Komiskey, H. L.; Murray, Thomas F.; Hayton, W. L.
In: Neurobiology of Aging, Vol. 5, No. 1, 1984, p. 49-53.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Aging
T2 - Effects on β-carboline binding in hippocampal subfields
AU - Zobrist, R. H.
AU - Komiskey, H. L.
AU - Murray, Thomas F.
AU - Hayton, W. L.
PY - 1984
Y1 - 1984
N2 - -The CA1 and CA4/area dentata subfields of the hippocampus in young, mature and old rats were examined for age-related change in propyl β-carboline-3-carboxylate (PrCC) binding. 3H-PrCC bound with high affinity (Kd=0.82 nM) to one binding site when ethyl β-carboline-3-carboxylate was used to delineate specific binding. An age dependent change in the maximum number of 3H-PrCC binding sites in the CA1 and CA4/area dentate subfields of the hippocampus were assessed by using a saturating (6 nM) concentration of 3H-PrCC. Although 3H-PrCC specific binding at a saturating concentration (6 nM) was significantly less in both the CA1 and CA4/area dentata subfields of the senescent rat, the magnitude of the decrease was greater in the CA1 region. In addition, the affinity of the 3H-PrCC binding site in both subfields probably did not vary significantly with age. Therefore, the CA1 and CA4/area dentate of the rat hippocampus may not only lose BZ1 receptors or the BZ1 receptors conformation with age, but the severity of receptor or receptor conformation loss varies with the subfield.
AB - -The CA1 and CA4/area dentata subfields of the hippocampus in young, mature and old rats were examined for age-related change in propyl β-carboline-3-carboxylate (PrCC) binding. 3H-PrCC bound with high affinity (Kd=0.82 nM) to one binding site when ethyl β-carboline-3-carboxylate was used to delineate specific binding. An age dependent change in the maximum number of 3H-PrCC binding sites in the CA1 and CA4/area dentate subfields of the hippocampus were assessed by using a saturating (6 nM) concentration of 3H-PrCC. Although 3H-PrCC specific binding at a saturating concentration (6 nM) was significantly less in both the CA1 and CA4/area dentata subfields of the senescent rat, the magnitude of the decrease was greater in the CA1 region. In addition, the affinity of the 3H-PrCC binding site in both subfields probably did not vary significantly with age. Therefore, the CA1 and CA4/area dentate of the rat hippocampus may not only lose BZ1 receptors or the BZ1 receptors conformation with age, but the severity of receptor or receptor conformation loss varies with the subfield.
UR - http://www.scopus.com/inward/record.url?scp=0021619889&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0021619889&partnerID=8YFLogxK
U2 - 10.1016/0197-4580(84)90085-X
DO - 10.1016/0197-4580(84)90085-X
M3 - Article
C2 - 6330592
AN - SCOPUS:0021619889
VL - 5
SP - 49
EP - 53
JO - Neurobiology of Aging
JF - Neurobiology of Aging
SN - 0197-4580
IS - 1
ER -