Alcohol consumption and the risk of breast cancer among BRCA1 and BRCA2 mutation carriers

Jessica Dennis, Parviz Ghadirian, Julian Little, Jan Lubinski, Jacek Gronwald, Charmaine Kim-Sing, William Foulkes, Pal Moller, Henry T. Lynch, Susan L. Neuhausen, Susan Domchek, Susan Armel, Claudine Isaacs, Nadine Tung, Kevin Sweet, Peter Ainsworth, Ping Sun, Daniel Krewski, Steven Narod

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Abstract

Alcohol consumption increases the risk of breast cancer among women in the general population, but its effect on women who carry a BRCA gene mutation is unclear. We conducted a case-control study of 1925 matched pairs of predominantly premenopausal women who carry a BRCA1 or a BRCA2 mutation. Information on current alcohol consumption was obtained from a questionnaire administered during the course of genetic counselling or at the time of enrolment. A modest inverse association between breast cancer and reported current alcohol consumption was observed among women with a BRCA1 mutation (OR = 0.82, 95% CI 0.70-0.96), but not among women with a BRCA2 mutation (OR = 1.00; 95% CI 0.71-1.41). Compared to non-drinkers, exclusive consumption of wine was associated with a significant reduction in the risk of breast cancer among BRCA1 carriers (p-trend = 0.01). Alcohol consumption does not appear to increase breast cancer risk in women carrying a BRCA gene mutation.

Original languageEnglish
Pages (from-to)479-483
Number of pages5
JournalBreast
Volume19
Issue number6
DOIs
StatePublished - Dec 2010

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Alcohol Drinking
Breast Neoplasms
Mutation
Genetic Counseling
Wine
Risk Reduction Behavior
Genes
Case-Control Studies
Population

All Science Journal Classification (ASJC) codes

  • Surgery

Cite this

Dennis, J., Ghadirian, P., Little, J., Lubinski, J., Gronwald, J., Kim-Sing, C., ... Narod, S. (2010). Alcohol consumption and the risk of breast cancer among BRCA1 and BRCA2 mutation carriers. Breast, 19(6), 479-483. https://doi.org/10.1016/j.breast.2010.05.009

Alcohol consumption and the risk of breast cancer among BRCA1 and BRCA2 mutation carriers. / Dennis, Jessica; Ghadirian, Parviz; Little, Julian; Lubinski, Jan; Gronwald, Jacek; Kim-Sing, Charmaine; Foulkes, William; Moller, Pal; Lynch, Henry T.; Neuhausen, Susan L.; Domchek, Susan; Armel, Susan; Isaacs, Claudine; Tung, Nadine; Sweet, Kevin; Ainsworth, Peter; Sun, Ping; Krewski, Daniel; Narod, Steven.

In: Breast, Vol. 19, No. 6, 12.2010, p. 479-483.

Research output: Contribution to journalArticle

Dennis, J, Ghadirian, P, Little, J, Lubinski, J, Gronwald, J, Kim-Sing, C, Foulkes, W, Moller, P, Lynch, HT, Neuhausen, SL, Domchek, S, Armel, S, Isaacs, C, Tung, N, Sweet, K, Ainsworth, P, Sun, P, Krewski, D & Narod, S 2010, 'Alcohol consumption and the risk of breast cancer among BRCA1 and BRCA2 mutation carriers', Breast, vol. 19, no. 6, pp. 479-483. https://doi.org/10.1016/j.breast.2010.05.009
Dennis J, Ghadirian P, Little J, Lubinski J, Gronwald J, Kim-Sing C et al. Alcohol consumption and the risk of breast cancer among BRCA1 and BRCA2 mutation carriers. Breast. 2010 Dec;19(6):479-483. https://doi.org/10.1016/j.breast.2010.05.009
Dennis, Jessica ; Ghadirian, Parviz ; Little, Julian ; Lubinski, Jan ; Gronwald, Jacek ; Kim-Sing, Charmaine ; Foulkes, William ; Moller, Pal ; Lynch, Henry T. ; Neuhausen, Susan L. ; Domchek, Susan ; Armel, Susan ; Isaacs, Claudine ; Tung, Nadine ; Sweet, Kevin ; Ainsworth, Peter ; Sun, Ping ; Krewski, Daniel ; Narod, Steven. / Alcohol consumption and the risk of breast cancer among BRCA1 and BRCA2 mutation carriers. In: Breast. 2010 ; Vol. 19, No. 6. pp. 479-483.
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