Alcohol consumption and the risk of breast cancer among BRCA1 and BRCA2 mutation carriers

Jessica Dennis; Parviz Ghadirian; Julian Little; Jan Lubinski; Jacek Gronwald; Charmaine Kim-Sing; William Foulkes; Pal Moller; Henry T. Lynch; Susan L. Neuhausen; Susan Domchek; Susan Armel; Claudine Isaacs; Nadine Tung; Kevin Sweet; Peter Ainsworth; Ping Sun; Daniel Krewski; Steven Narod

doi:10.1016/j.breast.2010.05.009

Alcohol consumption and the risk of breast cancer among BRCA1 and BRCA2 mutation carriers

Jessica Dennis, Parviz Ghadirian, Julian Little, Jan Lubinski, Jacek Gronwald, Charmaine Kim-Sing, William Foulkes, Pal Moller, Henry T. Lynch, Susan L. Neuhausen, Susan Domchek, Susan Armel, Claudine Isaacs, Nadine Tung, Kevin Sweet, Peter Ainsworth, Ping Sun, Daniel Krewski, Steven Narod

Department of Preventive Medicine

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Alcohol consumption increases the risk of breast cancer among women in the general population, but its effect on women who carry a BRCA gene mutation is unclear. We conducted a case-control study of 1925 matched pairs of predominantly premenopausal women who carry a BRCA1 or a BRCA2 mutation. Information on current alcohol consumption was obtained from a questionnaire administered during the course of genetic counselling or at the time of enrolment. A modest inverse association between breast cancer and reported current alcohol consumption was observed among women with a BRCA1 mutation (OR = 0.82, 95% CI 0.70-0.96), but not among women with a BRCA2 mutation (OR = 1.00; 95% CI 0.71-1.41). Compared to non-drinkers, exclusive consumption of wine was associated with a significant reduction in the risk of breast cancer among BRCA1 carriers (p-trend = 0.01). Alcohol consumption does not appear to increase breast cancer risk in women carrying a BRCA gene mutation.

Original language	English (US)
Pages (from-to)	479-483
Number of pages	5
Journal	Breast
Volume	19
Issue number	6
DOIs	https://doi.org/10.1016/j.breast.2010.05.009
State	Published - Dec 2010

All Science Journal Classification (ASJC) codes

Surgery

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Dennis, J., Ghadirian, P., Little, J., Lubinski, J., Gronwald, J., Kim-Sing, C., Foulkes, W., Moller, P., Lynch, H. T., Neuhausen, S. L., Domchek, S., Armel, S., Isaacs, C., Tung, N., Sweet, K., Ainsworth, P., Sun, P., Krewski, D., & Narod, S. (2010). Alcohol consumption and the risk of breast cancer among BRCA1 and BRCA2 mutation carriers. Breast, 19(6), 479-483. https://doi.org/10.1016/j.breast.2010.05.009

Alcohol consumption and the risk of breast cancer among BRCA1 and BRCA2 mutation carriers. / Dennis, Jessica; Ghadirian, Parviz; Little, Julian; Lubinski, Jan; Gronwald, Jacek; Kim-Sing, Charmaine; Foulkes, William; Moller, Pal; Lynch, Henry T.; Neuhausen, Susan L.; Domchek, Susan; Armel, Susan; Isaacs, Claudine; Tung, Nadine; Sweet, Kevin; Ainsworth, Peter; Sun, Ping; Krewski, Daniel; Narod, Steven.

In: Breast, Vol. 19, No. 6, 12.2010, p. 479-483.

Research output: Contribution to journal › Article › peer-review

Dennis, J, Ghadirian, P, Little, J, Lubinski, J, Gronwald, J, Kim-Sing, C, Foulkes, W, Moller, P, Lynch, HT, Neuhausen, SL, Domchek, S, Armel, S, Isaacs, C, Tung, N, Sweet, K, Ainsworth, P, Sun, P, Krewski, D & Narod, S 2010, 'Alcohol consumption and the risk of breast cancer among BRCA1 and BRCA2 mutation carriers', Breast, vol. 19, no. 6, pp. 479-483. https://doi.org/10.1016/j.breast.2010.05.009

Dennis, Jessica ; Ghadirian, Parviz ; Little, Julian ; Lubinski, Jan ; Gronwald, Jacek ; Kim-Sing, Charmaine ; Foulkes, William ; Moller, Pal ; Lynch, Henry T. ; Neuhausen, Susan L. ; Domchek, Susan ; Armel, Susan ; Isaacs, Claudine ; Tung, Nadine ; Sweet, Kevin ; Ainsworth, Peter ; Sun, Ping ; Krewski, Daniel ; Narod, Steven. / Alcohol consumption and the risk of breast cancer among BRCA1 and BRCA2 mutation carriers. In: Breast. 2010 ; Vol. 19, No. 6. pp. 479-483.

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title = "Alcohol consumption and the risk of breast cancer among BRCA1 and BRCA2 mutation carriers",

abstract = "Alcohol consumption increases the risk of breast cancer among women in the general population, but its effect on women who carry a BRCA gene mutation is unclear. We conducted a case-control study of 1925 matched pairs of predominantly premenopausal women who carry a BRCA1 or a BRCA2 mutation. Information on current alcohol consumption was obtained from a questionnaire administered during the course of genetic counselling or at the time of enrolment. A modest inverse association between breast cancer and reported current alcohol consumption was observed among women with a BRCA1 mutation (OR = 0.82, 95% CI 0.70-0.96), but not among women with a BRCA2 mutation (OR = 1.00; 95% CI 0.71-1.41). Compared to non-drinkers, exclusive consumption of wine was associated with a significant reduction in the risk of breast cancer among BRCA1 carriers (p-trend = 0.01). Alcohol consumption does not appear to increase breast cancer risk in women carrying a BRCA gene mutation.",

author = "Jessica Dennis and Parviz Ghadirian and Julian Little and Jan Lubinski and Jacek Gronwald and Charmaine Kim-Sing and William Foulkes and Pal Moller and Lynch, {Henry T.} and Neuhausen, {Susan L.} and Susan Domchek and Susan Armel and Claudine Isaacs and Nadine Tung and Kevin Sweet and Peter Ainsworth and Ping Sun and Daniel Krewski and Steven Narod",

note = "Funding Information: This research was supported by the Canadian Breast Cancer Research Alliance . D. Krewski holds the Natural Sciences and Engineering Research Council of Canada Chair in Risk Science at the University of Ottawa. J. Little holds a Canada Research Chair in Human Genome Epidemiology.",

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AU - Ghadirian, Parviz

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AU - Kim-Sing, Charmaine

AU - Foulkes, William

AU - Moller, Pal

AU - Lynch, Henry T.

AU - Neuhausen, Susan L.

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AU - Isaacs, Claudine

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AU - Sweet, Kevin

AU - Ainsworth, Peter

AU - Sun, Ping

AU - Krewski, Daniel

AU - Narod, Steven

N1 - Funding Information: This research was supported by the Canadian Breast Cancer Research Alliance . D. Krewski holds the Natural Sciences and Engineering Research Council of Canada Chair in Risk Science at the University of Ottawa. J. Little holds a Canada Research Chair in Human Genome Epidemiology.

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N2 - Alcohol consumption increases the risk of breast cancer among women in the general population, but its effect on women who carry a BRCA gene mutation is unclear. We conducted a case-control study of 1925 matched pairs of predominantly premenopausal women who carry a BRCA1 or a BRCA2 mutation. Information on current alcohol consumption was obtained from a questionnaire administered during the course of genetic counselling or at the time of enrolment. A modest inverse association between breast cancer and reported current alcohol consumption was observed among women with a BRCA1 mutation (OR = 0.82, 95% CI 0.70-0.96), but not among women with a BRCA2 mutation (OR = 1.00; 95% CI 0.71-1.41). Compared to non-drinkers, exclusive consumption of wine was associated with a significant reduction in the risk of breast cancer among BRCA1 carriers (p-trend = 0.01). Alcohol consumption does not appear to increase breast cancer risk in women carrying a BRCA gene mutation.

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Alcohol consumption and the risk of breast cancer among BRCA1 and BRCA2 mutation carriers

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