Alcohol consumption and the risk of breast cancer among BRCA1 and BRCA2 mutation carriers

Jessica Dennis; Parviz Ghadirian; Julian Little; Jan Lubinski; Jacek Gronwald; Charmaine Kim-Sing; William Foulkes; Pal Moller; Henry T. Lynch; Susan L. Neuhausen; Susan Domchek; Susan Armel; Claudine Isaacs; Nadine Tung; Kevin Sweet; Peter Ainsworth; Ping Sun; Daniel Krewski; Steven Narod

doi:10.1016/j.breast.2010.05.009

Alcohol consumption and the risk of breast cancer among BRCA1 and BRCA2 mutation carriers

Jessica Dennis, Parviz Ghadirian, Julian Little, Jan Lubinski, Jacek Gronwald, Charmaine Kim-Sing, William Foulkes, Pal Moller, Henry T. Lynch, Susan L. Neuhausen, Susan Domchek, Susan Armel, Claudine Isaacs, Nadine Tung, Kevin Sweet, Peter Ainsworth, Ping Sun, Daniel Krewski, Steven Narod

Department of Preventive Medicine

Research output: Contribution to journal › Article

18 Scopus citations

Abstract

Alcohol consumption increases the risk of breast cancer among women in the general population, but its effect on women who carry a BRCA gene mutation is unclear. We conducted a case-control study of 1925 matched pairs of predominantly premenopausal women who carry a BRCA1 or a BRCA2 mutation. Information on current alcohol consumption was obtained from a questionnaire administered during the course of genetic counselling or at the time of enrolment. A modest inverse association between breast cancer and reported current alcohol consumption was observed among women with a BRCA1 mutation (OR = 0.82, 95% CI 0.70-0.96), but not among women with a BRCA2 mutation (OR = 1.00; 95% CI 0.71-1.41). Compared to non-drinkers, exclusive consumption of wine was associated with a significant reduction in the risk of breast cancer among BRCA1 carriers (p-trend = 0.01). Alcohol consumption does not appear to increase breast cancer risk in women carrying a BRCA gene mutation.

Original language	English (US)
Pages (from-to)	479-483
Number of pages	5
Journal	Breast
Volume	19
Issue number	6
DOIs	https://doi.org/10.1016/j.breast.2010.05.009
State	Published - Dec 2010

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All Science Journal Classification (ASJC) codes

Surgery

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Dennis, J., Ghadirian, P., Little, J., Lubinski, J., Gronwald, J., Kim-Sing, C., Foulkes, W., Moller, P., Lynch, H. T., Neuhausen, S. L., Domchek, S., Armel, S., Isaacs, C., Tung, N., Sweet, K., Ainsworth, P., Sun, P., Krewski, D., & Narod, S. (2010). Alcohol consumption and the risk of breast cancer among BRCA1 and BRCA2 mutation carriers. Breast, 19(6), 479-483. https://doi.org/10.1016/j.breast.2010.05.009

Alcohol consumption and the risk of breast cancer among BRCA1 and BRCA2 mutation carriers. / Dennis, Jessica; Ghadirian, Parviz; Little, Julian; Lubinski, Jan; Gronwald, Jacek; Kim-Sing, Charmaine; Foulkes, William; Moller, Pal; Lynch, Henry T.; Neuhausen, Susan L.; Domchek, Susan; Armel, Susan; Isaacs, Claudine; Tung, Nadine; Sweet, Kevin; Ainsworth, Peter; Sun, Ping; Krewski, Daniel; Narod, Steven.

In: Breast, Vol. 19, No. 6, 12.2010, p. 479-483.

Research output: Contribution to journal › Article

Dennis, J, Ghadirian, P, Little, J, Lubinski, J, Gronwald, J, Kim-Sing, C, Foulkes, W, Moller, P, Lynch, HT, Neuhausen, SL, Domchek, S, Armel, S, Isaacs, C, Tung, N, Sweet, K, Ainsworth, P, Sun, P, Krewski, D & Narod, S 2010, 'Alcohol consumption and the risk of breast cancer among BRCA1 and BRCA2 mutation carriers', Breast, vol. 19, no. 6, pp. 479-483. https://doi.org/10.1016/j.breast.2010.05.009

Dennis, Jessica ; Ghadirian, Parviz ; Little, Julian ; Lubinski, Jan ; Gronwald, Jacek ; Kim-Sing, Charmaine ; Foulkes, William ; Moller, Pal ; Lynch, Henry T. ; Neuhausen, Susan L. ; Domchek, Susan ; Armel, Susan ; Isaacs, Claudine ; Tung, Nadine ; Sweet, Kevin ; Ainsworth, Peter ; Sun, Ping ; Krewski, Daniel ; Narod, Steven. / Alcohol consumption and the risk of breast cancer among BRCA1 and BRCA2 mutation carriers. In: Breast. 2010 ; Vol. 19, No. 6. pp. 479-483.

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abstract = "Alcohol consumption increases the risk of breast cancer among women in the general population, but its effect on women who carry a BRCA gene mutation is unclear. We conducted a case-control study of 1925 matched pairs of predominantly premenopausal women who carry a BRCA1 or a BRCA2 mutation. Information on current alcohol consumption was obtained from a questionnaire administered during the course of genetic counselling or at the time of enrolment. A modest inverse association between breast cancer and reported current alcohol consumption was observed among women with a BRCA1 mutation (OR = 0.82, 95% CI 0.70-0.96), but not among women with a BRCA2 mutation (OR = 1.00; 95% CI 0.71-1.41). Compared to non-drinkers, exclusive consumption of wine was associated with a significant reduction in the risk of breast cancer among BRCA1 carriers (p-trend = 0.01). Alcohol consumption does not appear to increase breast cancer risk in women carrying a BRCA gene mutation.",

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10.1016/j.breast.2010.05.009