Abstract
Alcohol consumption increases the risk of breast cancer among women in the general population, but its effect on women who carry a BRCA gene mutation is unclear. We conducted a case-control study of 1925 matched pairs of predominantly premenopausal women who carry a BRCA1 or a BRCA2 mutation. Information on current alcohol consumption was obtained from a questionnaire administered during the course of genetic counselling or at the time of enrolment. A modest inverse association between breast cancer and reported current alcohol consumption was observed among women with a BRCA1 mutation (OR = 0.82, 95% CI 0.70-0.96), but not among women with a BRCA2 mutation (OR = 1.00; 95% CI 0.71-1.41). Compared to non-drinkers, exclusive consumption of wine was associated with a significant reduction in the risk of breast cancer among BRCA1 carriers (p-trend = 0.01). Alcohol consumption does not appear to increase breast cancer risk in women carrying a BRCA gene mutation.
| Original language | English |
|---|---|
| Pages (from-to) | 479-483 |
| Number of pages | 5 |
| Journal | Breast |
| Volume | 19 |
| Issue number | 6 |
| DOIs | |
| State | Published - Dec 2010 |
Fingerprint
All Science Journal Classification (ASJC) codes
- Surgery
Cite this
Alcohol consumption and the risk of breast cancer among BRCA1 and BRCA2 mutation carriers. / Dennis, Jessica; Ghadirian, Parviz; Little, Julian; Lubinski, Jan; Gronwald, Jacek; Kim-Sing, Charmaine; Foulkes, William; Moller, Pal; Lynch, Henry T.; Neuhausen, Susan L.; Domchek, Susan; Armel, Susan; Isaacs, Claudine; Tung, Nadine; Sweet, Kevin; Ainsworth, Peter; Sun, Ping; Krewski, Daniel; Narod, Steven.
In: Breast, Vol. 19, No. 6, 12.2010, p. 479-483.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Alcohol consumption and the risk of breast cancer among BRCA1 and BRCA2 mutation carriers
AU - Dennis, Jessica
AU - Ghadirian, Parviz
AU - Little, Julian
AU - Lubinski, Jan
AU - Gronwald, Jacek
AU - Kim-Sing, Charmaine
AU - Foulkes, William
AU - Moller, Pal
AU - Lynch, Henry T.
AU - Neuhausen, Susan L.
AU - Domchek, Susan
AU - Armel, Susan
AU - Isaacs, Claudine
AU - Tung, Nadine
AU - Sweet, Kevin
AU - Ainsworth, Peter
AU - Sun, Ping
AU - Krewski, Daniel
AU - Narod, Steven
PY - 2010/12
Y1 - 2010/12
N2 - Alcohol consumption increases the risk of breast cancer among women in the general population, but its effect on women who carry a BRCA gene mutation is unclear. We conducted a case-control study of 1925 matched pairs of predominantly premenopausal women who carry a BRCA1 or a BRCA2 mutation. Information on current alcohol consumption was obtained from a questionnaire administered during the course of genetic counselling or at the time of enrolment. A modest inverse association between breast cancer and reported current alcohol consumption was observed among women with a BRCA1 mutation (OR = 0.82, 95% CI 0.70-0.96), but not among women with a BRCA2 mutation (OR = 1.00; 95% CI 0.71-1.41). Compared to non-drinkers, exclusive consumption of wine was associated with a significant reduction in the risk of breast cancer among BRCA1 carriers (p-trend = 0.01). Alcohol consumption does not appear to increase breast cancer risk in women carrying a BRCA gene mutation.
AB - Alcohol consumption increases the risk of breast cancer among women in the general population, but its effect on women who carry a BRCA gene mutation is unclear. We conducted a case-control study of 1925 matched pairs of predominantly premenopausal women who carry a BRCA1 or a BRCA2 mutation. Information on current alcohol consumption was obtained from a questionnaire administered during the course of genetic counselling or at the time of enrolment. A modest inverse association between breast cancer and reported current alcohol consumption was observed among women with a BRCA1 mutation (OR = 0.82, 95% CI 0.70-0.96), but not among women with a BRCA2 mutation (OR = 1.00; 95% CI 0.71-1.41). Compared to non-drinkers, exclusive consumption of wine was associated with a significant reduction in the risk of breast cancer among BRCA1 carriers (p-trend = 0.01). Alcohol consumption does not appear to increase breast cancer risk in women carrying a BRCA gene mutation.
UR - http://www.scopus.com/inward/record.url?scp=78449242708&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=78449242708&partnerID=8YFLogxK
U2 - 10.1016/j.breast.2010.05.009
DO - 10.1016/j.breast.2010.05.009
M3 - Article
C2 - 20541936
AN - SCOPUS:78449242708
VL - 19
SP - 479
EP - 483
JO - Breast
JF - Breast
SN - 0960-9776
IS - 6
ER -