Allele increasing susceptibility to human breast cancer may be linked to the glutamate-pyruvate transaminase locus

Mary Claire King, Rodney C P Go, Robert C. Elston, Henry T. Lynch, Nicholas L. Petrakis

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

The patterns of the occurrence of breast cancer in 11 high-risk families were evaluated by segregation and linkage analysis. These patterns were consistent with the hypothesis that increased susceptibility to breast cancer was inherited as an autosomal dominant allele with high penetrance in women. The postulated susceptibility allele in these families may be chromosomally linked to the glutamate-pyruvate transaminase (E.C. 2.6.1.2, alanine aminotransferase) locus. Confirmation of this linkage in other families would establish the existence of a gene increasing susceptibility to breast cancer. Since there is no association in the general population between a woman's glutamate-pyruvate transaminase genotype and her cancer risk, the glutamate-pyruvate transaminase linkage cannot be used as a screening test for breast cancer.

Original languageEnglish
Pages (from-to)407-408
Number of pages2
JournalScience
Volume208
Issue number4442
StatePublished - 1980

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Transaminases
Pyruvic Acid
Glutamic Acid
Alleles
Breast Neoplasms
Penetrance
Alanine Transaminase
Genotype
Population
Genes
Neoplasms

All Science Journal Classification (ASJC) codes

  • General

Cite this

King, M. C., Go, R. C. P., Elston, R. C., Lynch, H. T., & Petrakis, N. L. (1980). Allele increasing susceptibility to human breast cancer may be linked to the glutamate-pyruvate transaminase locus. Science, 208(4442), 407-408.

Allele increasing susceptibility to human breast cancer may be linked to the glutamate-pyruvate transaminase locus. / King, Mary Claire; Go, Rodney C P; Elston, Robert C.; Lynch, Henry T.; Petrakis, Nicholas L.

In: Science, Vol. 208, No. 4442, 1980, p. 407-408.

Research output: Contribution to journalArticle

King, MC, Go, RCP, Elston, RC, Lynch, HT & Petrakis, NL 1980, 'Allele increasing susceptibility to human breast cancer may be linked to the glutamate-pyruvate transaminase locus', Science, vol. 208, no. 4442, pp. 407-408.
King, Mary Claire ; Go, Rodney C P ; Elston, Robert C. ; Lynch, Henry T. ; Petrakis, Nicholas L. / Allele increasing susceptibility to human breast cancer may be linked to the glutamate-pyruvate transaminase locus. In: Science. 1980 ; Vol. 208, No. 4442. pp. 407-408.
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