Allelic variation in genes encoding Panton-Valentine leukocidin from community-associated Staphylococcus aureus

D. J. Wolter, F. C. Tenover, Richard V. Goering

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Community-associated methicillin-resistant Staphylococcus aureus isolates characteristically contain the genes for Panton-Valentine leukocidin (PVL), which is a proposed virulence factor. To determine whether different alleles of the PVL genes lukS-PV and lukF-PV occur, and whether they are associated with specific genetic lineages of S. aureus, sequences from 28 S. aureus isolates, representing four different multilocus sequence types, and bacteriophages SLT and PVL were compared. Seven nucleotide polymorphisms were identified, which defined three groups of the lukS-PV and lukF-PV sequence. Only one polymorphism resulted in an amino-acid change. Bacteriophage SLT and isolates of bacteriophage type 80/81 contained the prototypic (founder) lukS-PV and lukF-PV sequence. The alleles were not lineage-specific.

Original languageEnglish
Pages (from-to)827-830
Number of pages4
JournalClinical Microbiology and Infection
Volume13
Issue number8
DOIs
StatePublished - Aug 2007

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Staphylococcus aureus
Bacteriophages
Genes
Alleles
Virulence Factors
Methicillin-Resistant Staphylococcus aureus
Panton-Valentine leukocidin
Nucleotides
Amino Acids

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Microbiology

Cite this

Allelic variation in genes encoding Panton-Valentine leukocidin from community-associated Staphylococcus aureus. / Wolter, D. J.; Tenover, F. C.; Goering, Richard V.

In: Clinical Microbiology and Infection, Vol. 13, No. 8, 08.2007, p. 827-830.

Research output: Contribution to journalArticle

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