Allergic airway inflammation

Devendra K. Agrawal, Arpita Bharadwaj

Research output: Contribution to journalReview article

20 Scopus citations

Abstract

Several genes, including ADAM33, DPP10, PHF11, GPRA, and TIM-1, have been implicated in the pathogenesis and suscepitibility to atopy and asthma. Advances have been made in defining the mechanism for the control of allergic airway inflammation in response to inhaled antigens. There is growing evidence that associates asthma with a systemic propensity for allergic type 2 T-cell cytokines. Disordered coagulation and fibrinolysis could also exacerbate asthma symptoms. Major emphasis on immunotherapy for asthma during the past decade has been to direct the immune response to a type 1 response. Recent literature supports the pivotal role of plasmacytoid dendritic cells and allergen-specific T-regulatory cells in the development of tolerance to allergens. In this review article, we discuss the current information on the pathogenesis of allergic airway inflammation and potential allergen immunotherapies, which could be beneficial in the treatment of airway inflammation, allergy, and asthma.

Original languageEnglish
Pages (from-to)142-148
Number of pages7
JournalCurrent Allergy and Asthma Reports
Volume5
Issue number2
Publication statusPublished - Mar 2005

    Fingerprint

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Agrawal, D. K., & Bharadwaj, A. (2005). Allergic airway inflammation. Current Allergy and Asthma Reports, 5(2), 142-148.