Allosteric nucleic acid catalysts

Garrett Soukup, Ronald R. Breaker

Research output: Contribution to journalReview article

112 Citations (Scopus)

Abstract

Endowing nucleic acid catalysts with allosteric properties provides new prospects for RNA and DNA as controllable therapeutic agents or as sensors of their cognate effector compounds. The ability to engineer RNA catalysts that are allosterically regulated by effector binding has been propelled by the union of modular rational design principles and powerful combinatorial strategies.

Original languageEnglish
Pages (from-to)318-325
Number of pages8
JournalCurrent Opinion in Structural Biology
Volume10
Issue number3
DOIs
StatePublished - Jun 1 2000

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Nucleic Acids
RNA
DNA
Therapeutics

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Structural Biology

Cite this

Allosteric nucleic acid catalysts. / Soukup, Garrett; Breaker, Ronald R.

In: Current Opinion in Structural Biology, Vol. 10, No. 3, 01.06.2000, p. 318-325.

Research output: Contribution to journalReview article

Soukup, Garrett ; Breaker, Ronald R. / Allosteric nucleic acid catalysts. In: Current Opinion in Structural Biology. 2000 ; Vol. 10, No. 3. pp. 318-325.
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