Allosteric nucleic acid catalysts

Garrett A. Soukup; Ronald R. Breaker

doi:10.1016/S0959-440X(00)00090-7

Allosteric nucleic acid catalysts

Garrett A. Soukup, Ronald R. Breaker

Research output: Contribution to journal › Review article › peer-review

116 Scopus citations

Abstract

Endowing nucleic acid catalysts with allosteric properties provides new prospects for RNA and DNA as controllable therapeutic agents or as sensors of their cognate effector compounds. The ability to engineer RNA catalysts that are allosterically regulated by effector binding has been propelled by the union of modular rational design principles and powerful combinatorial strategies.

Original language	English (US)
Pages (from-to)	318-325
Number of pages	8
Journal	Current Opinion in Structural Biology
Volume	10
Issue number	3
DOIs	https://doi.org/10.1016/S0959-440X(00)00090-7
State	Published - Jun 1 2000
Externally published	Yes

All Science Journal Classification (ASJC) codes

Structural Biology
Molecular Biology

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10.1016/S0959-440X(00)00090-7

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abstract = "Endowing nucleic acid catalysts with allosteric properties provides new prospects for RNA and DNA as controllable therapeutic agents or as sensors of their cognate effector compounds. The ability to engineer RNA catalysts that are allosterically regulated by effector binding has been propelled by the union of modular rational design principles and powerful combinatorial strategies.",

author = "Soukup, {Garrett A.} and Breaker, {Ronald R.}",

note = "Funding Information: We thank GAM Emilsson for critical reading of the manuscript and other members of the Breaker laboratory for helpful discussions. This work was supported by research grants from the National Institutes of Health (GM559343), DARPA and the Yale Diabetes Endocrine Research Center (DERC). Support is also provided by fellowships to RRB from the Hellman Family and from the David and Lucile Packard Foundation. ",

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AU - Soukup, Garrett A.

AU - Breaker, Ronald R.

N1 - Funding Information: We thank GAM Emilsson for critical reading of the manuscript and other members of the Breaker laboratory for helpful discussions. This work was supported by research grants from the National Institutes of Health (GM559343), DARPA and the Yale Diabetes Endocrine Research Center (DERC). Support is also provided by fellowships to RRB from the Hellman Family and from the David and Lucile Packard Foundation.

PY - 2000/6/1

Y1 - 2000/6/1

N2 - Endowing nucleic acid catalysts with allosteric properties provides new prospects for RNA and DNA as controllable therapeutic agents or as sensors of their cognate effector compounds. The ability to engineer RNA catalysts that are allosterically regulated by effector binding has been propelled by the union of modular rational design principles and powerful combinatorial strategies.

AB - Endowing nucleic acid catalysts with allosteric properties provides new prospects for RNA and DNA as controllable therapeutic agents or as sensors of their cognate effector compounds. The ability to engineer RNA catalysts that are allosterically regulated by effector binding has been propelled by the union of modular rational design principles and powerful combinatorial strategies.

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DO - 10.1016/S0959-440X(00)00090-7

M3 - Review article

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JO - Current Opinion in Structural Biology

JF - Current Opinion in Structural Biology

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Allosteric nucleic acid catalysts

Abstract

All Science Journal Classification (ASJC) codes

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