Allosteric nucleic acid catalysts

Garrett A. Soukup, Ronald R. Breaker

Research output: Contribution to journalReview articlepeer-review

119 Scopus citations


Endowing nucleic acid catalysts with allosteric properties provides new prospects for RNA and DNA as controllable therapeutic agents or as sensors of their cognate effector compounds. The ability to engineer RNA catalysts that are allosterically regulated by effector binding has been propelled by the union of modular rational design principles and powerful combinatorial strategies.

Original languageEnglish (US)
Pages (from-to)318-325
Number of pages8
JournalCurrent Opinion in Structural Biology
Issue number3
StatePublished - Jun 1 2000
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Structural Biology
  • Molecular Biology


Dive into the research topics of 'Allosteric nucleic acid catalysts'. Together they form a unique fingerprint.

Cite this