Allosteric nucleic acid catalysts

Garrett A. Soukup, Ronald R. Breaker

Research output: Contribution to journalReview article

114 Scopus citations

Abstract

Endowing nucleic acid catalysts with allosteric properties provides new prospects for RNA and DNA as controllable therapeutic agents or as sensors of their cognate effector compounds. The ability to engineer RNA catalysts that are allosterically regulated by effector binding has been propelled by the union of modular rational design principles and powerful combinatorial strategies.

Original languageEnglish (US)
Pages (from-to)318-325
Number of pages8
JournalCurrent Opinion in Structural Biology
Volume10
Issue number3
DOIs
StatePublished - Jun 1 2000

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All Science Journal Classification (ASJC) codes

  • Structural Biology
  • Molecular Biology

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