Abstract
Endowing nucleic acid catalysts with allosteric properties provides new prospects for RNA and DNA as controllable therapeutic agents or as sensors of their cognate effector compounds. The ability to engineer RNA catalysts that are allosterically regulated by effector binding has been propelled by the union of modular rational design principles and powerful combinatorial strategies.
Original language | English (US) |
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Pages (from-to) | 318-325 |
Number of pages | 8 |
Journal | Current Opinion in Structural Biology |
Volume | 10 |
Issue number | 3 |
DOIs | |
State | Published - Jun 1 2000 |
Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Structural Biology
- Molecular Biology