Alotamide A, a novel neuropharmacological agent from the marine cyanobacterium Lyngbya bouillonii

Irma E. Soria-Mercado, Alban Pereira, Zhengyu Cao, Thomas F. Murray, William H. Gerwick

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Alotamide A (1), a structurally Intriguing cyclic depsipeptide, was isolated from the marine mat-forming cyanobacterlum Lyngbya bouillonii collected In Papua New Guinea. It features three contiguous peptidic residues and an unsaturated heptaketide with oxidations and methylations unlike those found In any other marine cyanobacterial metabolite. Pure alotamide A (1) displays an unusual calcium influx activation profile In murine cerebrocortical neurons with an EC50 of 4.18 ¡uU.

Original languageEnglish
Pages (from-to)4704-4707
Number of pages4
JournalOrganic Letters
Volume11
Issue number20
DOIs
StatePublished - Oct 15 2009

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Papua New Guinea
methylation
metabolites
Cyanobacteria
neurons
calcium
Depsipeptides
activation
oxidation
Methylation
Metabolites
profiles
Neurons
Chemical activation
Calcium
Oxidation
alotamide A

All Science Journal Classification (ASJC) codes

  • Organic Chemistry
  • Physical and Theoretical Chemistry
  • Biochemistry

Cite this

Alotamide A, a novel neuropharmacological agent from the marine cyanobacterium Lyngbya bouillonii. / Soria-Mercado, Irma E.; Pereira, Alban; Cao, Zhengyu; Murray, Thomas F.; Gerwick, William H.

In: Organic Letters, Vol. 11, No. 20, 15.10.2009, p. 4704-4707.

Research output: Contribution to journalArticle

Soria-Mercado, Irma E. ; Pereira, Alban ; Cao, Zhengyu ; Murray, Thomas F. ; Gerwick, William H. / Alotamide A, a novel neuropharmacological agent from the marine cyanobacterium Lyngbya bouillonii. In: Organic Letters. 2009 ; Vol. 11, No. 20. pp. 4704-4707.
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