Alotamide A, a novel neuropharmacological agent from the marine cyanobacterium Lyngbya bouillonii

Irma E. Soria-Mercado, Alban Pereira, Zhengyu Cao, Thomas F. Murray, William H. Gerwick

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Abstract

Alotamide A (1), a structurally Intriguing cyclic depsipeptide, was isolated from the marine mat-forming cyanobacterlum Lyngbya bouillonii collected In Papua New Guinea. It features three contiguous peptidic residues and an unsaturated heptaketide with oxidations and methylations unlike those found In any other marine cyanobacterial metabolite. Pure alotamide A (1) displays an unusual calcium influx activation profile In murine cerebrocortical neurons with an EC50 of 4.18 ¡uU.

Original languageEnglish
Pages (from-to)4704-4707
Number of pages4
JournalOrganic Letters
Volume11
Issue number20
DOIs
StatePublished - Oct 15 2009

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All Science Journal Classification (ASJC) codes

  • Organic Chemistry
  • Physical and Theoretical Chemistry
  • Biochemistry

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