Alotamide A, a novel neuropharmacological agent from the marine cyanobacterium Lyngbya bouillonii

Irma E. Soria-Mercado; Alban Pereira; Zhengyu Cao; Thomas F. Murray; William H. Gerwick

doi:10.1021/ol901438b

Alotamide A, a novel neuropharmacological agent from the marine cyanobacterium Lyngbya bouillonii

Irma E. Soria-Mercado, Alban Pereira, Zhengyu Cao, Thomas F. Murray, William H. Gerwick

Department of Pharmacology and Neuroscience

Research output: Contribution to journal › Article › peer-review

49 Scopus citations

Abstract

Alotamide A (1), a structurally Intriguing cyclic depsipeptide, was isolated from the marine mat-forming cyanobacterlum Lyngbya bouillonii collected In Papua New Guinea. It features three contiguous peptidic residues and an unsaturated heptaketide with oxidations and methylations unlike those found In any other marine cyanobacterial metabolite. Pure alotamide A (1) displays an unusual calcium influx activation profile In murine cerebrocortical neurons with an EC₅₀ of 4.18 ¡uU.

Original language	English (US)
Pages (from-to)	4704-4707
Number of pages	4
Journal	Organic Letters
Volume	11
Issue number	20
DOIs	https://doi.org/10.1021/ol901438b
State	Published - Oct 15 2009

All Science Journal Classification (ASJC) codes

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

Access to Document

10.1021/ol901438b

Cite this

@article{4fd37e2c5cfe4e449276a1d82610ffd7,

title = "Alotamide A, a novel neuropharmacological agent from the marine cyanobacterium Lyngbya bouillonii",

abstract = "Alotamide A (1), a structurally Intriguing cyclic depsipeptide, was isolated from the marine mat-forming cyanobacterlum Lyngbya bouillonii collected In Papua New Guinea. It features three contiguous peptidic residues and an unsaturated heptaketide with oxidations and methylations unlike those found In any other marine cyanobacterial metabolite. Pure alotamide A (1) displays an unusual calcium influx activation profile In murine cerebrocortical neurons with an EC50 of 4.18 ¡uU.",

author = "Soria-Mercado, {Irma E.} and Alban Pereira and Zhengyu Cao and Murray, {Thomas F.} and Gerwick, {William H.}",

year = "2009",

month = oct,

day = "15",

doi = "10.1021/ol901438b",

language = "English (US)",

volume = "11",

pages = "4704--4707",

journal = "Organic Letters",

issn = "1523-7060",

publisher = "American Chemical Society",

number = "20",

}

TY - JOUR

T1 - Alotamide A, a novel neuropharmacological agent from the marine cyanobacterium Lyngbya bouillonii

AU - Soria-Mercado, Irma E.

AU - Pereira, Alban

AU - Cao, Zhengyu

AU - Murray, Thomas F.

AU - Gerwick, William H.

PY - 2009/10/15

Y1 - 2009/10/15

N2 - Alotamide A (1), a structurally Intriguing cyclic depsipeptide, was isolated from the marine mat-forming cyanobacterlum Lyngbya bouillonii collected In Papua New Guinea. It features three contiguous peptidic residues and an unsaturated heptaketide with oxidations and methylations unlike those found In any other marine cyanobacterial metabolite. Pure alotamide A (1) displays an unusual calcium influx activation profile In murine cerebrocortical neurons with an EC50 of 4.18 ¡uU.

AB - Alotamide A (1), a structurally Intriguing cyclic depsipeptide, was isolated from the marine mat-forming cyanobacterlum Lyngbya bouillonii collected In Papua New Guinea. It features three contiguous peptidic residues and an unsaturated heptaketide with oxidations and methylations unlike those found In any other marine cyanobacterial metabolite. Pure alotamide A (1) displays an unusual calcium influx activation profile In murine cerebrocortical neurons with an EC50 of 4.18 ¡uU.

UR - http://www.scopus.com/inward/record.url?scp=70349934410&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=70349934410&partnerID=8YFLogxK

U2 - 10.1021/ol901438b

DO - 10.1021/ol901438b

M3 - Article

C2 - 19754100

AN - SCOPUS:70349934410

VL - 11

SP - 4704

EP - 4707

JO - Organic Letters

JF - Organic Letters

SN - 1523-7060

IS - 20

ER -

Alotamide A, a novel neuropharmacological agent from the marine cyanobacterium Lyngbya bouillonii

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this