Abstract
Alotamide A (1), a structurally Intriguing cyclic depsipeptide, was isolated from the marine mat-forming cyanobacterlum Lyngbya bouillonii collected In Papua New Guinea. It features three contiguous peptidic residues and an unsaturated heptaketide with oxidations and methylations unlike those found In any other marine cyanobacterial metabolite. Pure alotamide A (1) displays an unusual calcium influx activation profile In murine cerebrocortical neurons with an EC50 of 4.18 ¡uU.
| Original language | English |
|---|---|
| Pages (from-to) | 4704-4707 |
| Number of pages | 4 |
| Journal | Organic Letters |
| Volume | 11 |
| Issue number | 20 |
| DOIs | |
| State | Published - Oct 15 2009 |
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All Science Journal Classification (ASJC) codes
- Organic Chemistry
- Physical and Theoretical Chemistry
- Biochemistry
Cite this
Alotamide A, a novel neuropharmacological agent from the marine cyanobacterium Lyngbya bouillonii. / Soria-Mercado, Irma E.; Pereira, Alban; Cao, Zhengyu; Murray, Thomas F.; Gerwick, William H.
In: Organic Letters, Vol. 11, No. 20, 15.10.2009, p. 4704-4707.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Alotamide A, a novel neuropharmacological agent from the marine cyanobacterium Lyngbya bouillonii
AU - Soria-Mercado, Irma E.
AU - Pereira, Alban
AU - Cao, Zhengyu
AU - Murray, Thomas F.
AU - Gerwick, William H.
PY - 2009/10/15
Y1 - 2009/10/15
N2 - Alotamide A (1), a structurally Intriguing cyclic depsipeptide, was isolated from the marine mat-forming cyanobacterlum Lyngbya bouillonii collected In Papua New Guinea. It features three contiguous peptidic residues and an unsaturated heptaketide with oxidations and methylations unlike those found In any other marine cyanobacterial metabolite. Pure alotamide A (1) displays an unusual calcium influx activation profile In murine cerebrocortical neurons with an EC50 of 4.18 ¡uU.
AB - Alotamide A (1), a structurally Intriguing cyclic depsipeptide, was isolated from the marine mat-forming cyanobacterlum Lyngbya bouillonii collected In Papua New Guinea. It features three contiguous peptidic residues and an unsaturated heptaketide with oxidations and methylations unlike those found In any other marine cyanobacterial metabolite. Pure alotamide A (1) displays an unusual calcium influx activation profile In murine cerebrocortical neurons with an EC50 of 4.18 ¡uU.
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UR - http://www.scopus.com/inward/citedby.url?scp=70349934410&partnerID=8YFLogxK
U2 - 10.1021/ol901438b
DO - 10.1021/ol901438b
M3 - Article
VL - 11
SP - 4704
EP - 4707
JO - Organic Letters
JF - Organic Letters
SN - 1523-7060
IS - 20
ER -