Alotamide A, a novel neuropharmacological agent from the marine cyanobacterium Lyngbya bouillonii

Irma E. Soria-Mercado; Alban Pereira; Zhengyu Cao; Thomas F. Murray; William H. Gerwick

doi:10.1021/ol901438b

Alotamide A, a novel neuropharmacological agent from the marine cyanobacterium Lyngbya bouillonii

Irma E. Soria-Mercado, Alban Pereira, Zhengyu Cao, Thomas F. Murray, William H. Gerwick

Department of Pharmacology and Neuroscience

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

Alotamide A (1), a structurally Intriguing cyclic depsipeptide, was isolated from the marine mat-forming cyanobacterlum Lyngbya bouillonii collected In Papua New Guinea. It features three contiguous peptidic residues and an unsaturated heptaketide with oxidations and methylations unlike those found In any other marine cyanobacterial metabolite. Pure alotamide A (1) displays an unusual calcium influx activation profile In murine cerebrocortical neurons with an EC₅₀ of 4.18 ¡uU.

Original language	English (US)
Pages (from-to)	4704-4707
Number of pages	4
Journal	Organic Letters
Volume	11
Issue number	20
DOIs	https://doi.org/10.1021/ol901438b
State	Published - Oct 15 2009

All Science Journal Classification (ASJC) codes

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol901438b

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AU - Soria-Mercado, Irma E.

AU - Pereira, Alban

AU - Cao, Zhengyu

AU - Murray, Thomas F.

AU - Gerwick, William H.

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AB - Alotamide A (1), a structurally Intriguing cyclic depsipeptide, was isolated from the marine mat-forming cyanobacterlum Lyngbya bouillonii collected In Papua New Guinea. It features three contiguous peptidic residues and an unsaturated heptaketide with oxidations and methylations unlike those found In any other marine cyanobacterial metabolite. Pure alotamide A (1) displays an unusual calcium influx activation profile In murine cerebrocortical neurons with an EC50 of 4.18 ¡uU.

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