Abstract
Alotamide A (1), a structurally Intriguing cyclic depsipeptide, was isolated from the marine mat-forming cyanobacterlum Lyngbya bouillonii collected In Papua New Guinea. It features three contiguous peptidic residues and an unsaturated heptaketide with oxidations and methylations unlike those found In any other marine cyanobacterial metabolite. Pure alotamide A (1) displays an unusual calcium influx activation profile In murine cerebrocortical neurons with an EC50 of 4.18 ¡uU.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 4704-4707 |
| Number of pages | 4 |
| Journal | Organic Letters |
| Volume | 11 |
| Issue number | 20 |
| DOIs | |
| State | Published - Oct 15 2009 |
All Science Journal Classification (ASJC) codes
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry
Fingerprint Dive into the research topics of 'Alotamide A, a novel neuropharmacological agent from the marine cyanobacterium Lyngbya bouillonii'. Together they form a unique fingerprint.
Cite this
Soria-Mercado, I. E., Pereira, A., Cao, Z., Murray, T. F., & Gerwick, W. H. (2009). Alotamide A, a novel neuropharmacological agent from the marine cyanobacterium Lyngbya bouillonii. Organic Letters, 11(20), 4704-4707. https://doi.org/10.1021/ol901438b