Abstract
Objective: Natural menopause is a key physiological event in a woman's life. Timing of menopause affects risk for many postmenopausal systemic disorders and may thus influence life expectancy. Age at natural menopause (ANM) is largely determined genetically, but a list of candidate genes is far from complete. This study investigated the ALOX12 gene for its possible association with ANM. Methods: Six single-nucleotide polymorphisms (SNPs) of the gene (rs9904779, rs2073438, rs11571340, rs434473, rs2307214, and rs312462) were genotyped in a random sample of 210 unrelated white women. The SNPs and common haplotypes were then analyzed for their association with ANM. Smoking, alcohol consumption, and duration of breast-feeding were used as covariates. Results: Two SNPs, rs9904779 and rs434473 (encodes a replacement of asparagine by serine in the protein), were significantly associated with ANM (P = 0.022 and 0.033, respectively). The minor alleles of both SNPs seem to promote about 1.3-to 1.5-year earlier menopause and confer a 1.6 to 1.8 times higher risk for early menopause. All SNPs indicated significant or nearly significant interactions with alcohol use and duration of breast-feeding. Five common haplotypes were also associated with ANM. Conclusions: The ALOX12 gene seems to be associated with the timing of natural menopause in white women.
| Original language | English |
|---|---|
| Pages (from-to) | 152-156 |
| Number of pages | 5 |
| Journal | Menopause |
| Volume | 17 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 2010 |
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All Science Journal Classification (ASJC) codes
- Obstetrics and Gynecology
Cite this
Alox12 gene is associated with the onset of natural menopause in white women. / Liu, Pengyuan; Lu, Yan; Recker, Robert R.; Deng, Hong Wen; Dvornyk, Volodymyr.
In: Menopause, Vol. 17, No. 1, 01.2010, p. 152-156.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Alox12 gene is associated with the onset of natural menopause in white women
AU - Liu, Pengyuan
AU - Lu, Yan
AU - Recker, Robert R.
AU - Deng, Hong Wen
AU - Dvornyk, Volodymyr
PY - 2010/1
Y1 - 2010/1
N2 - Objective: Natural menopause is a key physiological event in a woman's life. Timing of menopause affects risk for many postmenopausal systemic disorders and may thus influence life expectancy. Age at natural menopause (ANM) is largely determined genetically, but a list of candidate genes is far from complete. This study investigated the ALOX12 gene for its possible association with ANM. Methods: Six single-nucleotide polymorphisms (SNPs) of the gene (rs9904779, rs2073438, rs11571340, rs434473, rs2307214, and rs312462) were genotyped in a random sample of 210 unrelated white women. The SNPs and common haplotypes were then analyzed for their association with ANM. Smoking, alcohol consumption, and duration of breast-feeding were used as covariates. Results: Two SNPs, rs9904779 and rs434473 (encodes a replacement of asparagine by serine in the protein), were significantly associated with ANM (P = 0.022 and 0.033, respectively). The minor alleles of both SNPs seem to promote about 1.3-to 1.5-year earlier menopause and confer a 1.6 to 1.8 times higher risk for early menopause. All SNPs indicated significant or nearly significant interactions with alcohol use and duration of breast-feeding. Five common haplotypes were also associated with ANM. Conclusions: The ALOX12 gene seems to be associated with the timing of natural menopause in white women.
AB - Objective: Natural menopause is a key physiological event in a woman's life. Timing of menopause affects risk for many postmenopausal systemic disorders and may thus influence life expectancy. Age at natural menopause (ANM) is largely determined genetically, but a list of candidate genes is far from complete. This study investigated the ALOX12 gene for its possible association with ANM. Methods: Six single-nucleotide polymorphisms (SNPs) of the gene (rs9904779, rs2073438, rs11571340, rs434473, rs2307214, and rs312462) were genotyped in a random sample of 210 unrelated white women. The SNPs and common haplotypes were then analyzed for their association with ANM. Smoking, alcohol consumption, and duration of breast-feeding were used as covariates. Results: Two SNPs, rs9904779 and rs434473 (encodes a replacement of asparagine by serine in the protein), were significantly associated with ANM (P = 0.022 and 0.033, respectively). The minor alleles of both SNPs seem to promote about 1.3-to 1.5-year earlier menopause and confer a 1.6 to 1.8 times higher risk for early menopause. All SNPs indicated significant or nearly significant interactions with alcohol use and duration of breast-feeding. Five common haplotypes were also associated with ANM. Conclusions: The ALOX12 gene seems to be associated with the timing of natural menopause in white women.
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U2 - 10.1097/gme.0b013e3181b63c68
DO - 10.1097/gme.0b013e3181b63c68
M3 - Article
VL - 17
SP - 152
EP - 156
JO - Menopause
JF - Menopause
SN - 1072-3714
IS - 1
ER -