Alox12 gene is associated with the onset of natural menopause in white women

Pengyuan Liu, Yan Lu, Robert R. Recker, Hong Wen Deng, Volodymyr Dvornyk

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Objective: Natural menopause is a key physiological event in a woman's life. Timing of menopause affects risk for many postmenopausal systemic disorders and may thus influence life expectancy. Age at natural menopause (ANM) is largely determined genetically, but a list of candidate genes is far from complete. This study investigated the ALOX12 gene for its possible association with ANM. Methods: Six single-nucleotide polymorphisms (SNPs) of the gene (rs9904779, rs2073438, rs11571340, rs434473, rs2307214, and rs312462) were genotyped in a random sample of 210 unrelated white women. The SNPs and common haplotypes were then analyzed for their association with ANM. Smoking, alcohol consumption, and duration of breast-feeding were used as covariates. Results: Two SNPs, rs9904779 and rs434473 (encodes a replacement of asparagine by serine in the protein), were significantly associated with ANM (P = 0.022 and 0.033, respectively). The minor alleles of both SNPs seem to promote about 1.3-to 1.5-year earlier menopause and confer a 1.6 to 1.8 times higher risk for early menopause. All SNPs indicated significant or nearly significant interactions with alcohol use and duration of breast-feeding. Five common haplotypes were also associated with ANM. Conclusions: The ALOX12 gene seems to be associated with the timing of natural menopause in white women.

Original languageEnglish
Pages (from-to)152-156
Number of pages5
JournalMenopause
Volume17
Issue number1
DOIs
StatePublished - Jan 2010

Fingerprint

Menopause
Genes
Single Nucleotide Polymorphism
Breast Feeding
Haplotypes
Asparagine
Life Expectancy
Alcohol Drinking
Serine
Smoking
Alleles
Alcohols

All Science Journal Classification (ASJC) codes

  • Obstetrics and Gynecology

Cite this

Alox12 gene is associated with the onset of natural menopause in white women. / Liu, Pengyuan; Lu, Yan; Recker, Robert R.; Deng, Hong Wen; Dvornyk, Volodymyr.

In: Menopause, Vol. 17, No. 1, 01.2010, p. 152-156.

Research output: Contribution to journalArticle

Liu, Pengyuan ; Lu, Yan ; Recker, Robert R. ; Deng, Hong Wen ; Dvornyk, Volodymyr. / Alox12 gene is associated with the onset of natural menopause in white women. In: Menopause. 2010 ; Vol. 17, No. 1. pp. 152-156.
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