Alterations in tendon microenvironment in response to mechanical load: Potential molecular targets for treatment strategies

Mohamed B. Fouda, Finosh G. Thankam, Matthew Dilisio, Devendra K. Agrawal

Research output: Contribution to journalReview article

6 Citations (Scopus)

Abstract

Rotator cuff (RC) tendons could beinflicted in many ways with an eventual outcome of pain, weakness and disability, which represent a large burden on health care cost. However, optimal healing, either conservatively or with surgical intervention, remains an issue that needs further investigation. Disorders of the RC tendons may result from external factors like trauma, or internal factors through physiologic and metabolic derangement. Most RC tendon disorders may be asymptomatic and may result from an over-activity of the inflicted shoulder and its tendons. Such tendon disorders are poorly diagnosed since patients do not seek medical attention until pain or weakness ensue. Immunological and biochemical events in RC disorders due to mechanical intolerance have not been investigated. Generally, the mechanical load drives normal physiological properties of the tendon. But, mechanical overload/burden exerts stress on tenocytes, and disrupts the tendon microenvironment by triggering a multitude of signaling pathways leading to extracellular matrix remodeling, disorganization, alteration in collagen composition and apoptosis. These events result in weak tendon which is highly susceptible to rupture or tear. In this article, we critically reviewed the intrinsic signaling pathways that are excessively triggered by continuous mechanical load and the counteracting physiological responses and associated derangements. The elucidation of the molecular events underlying mechanical stress-induced symptomatic/asymptomatic tendinopathy could provide information on potential target sites for translational application in the management of rotator cuff disorders.

Original languageEnglish (US)
Article numberAJTR0059913
Pages (from-to)4341-4360
Number of pages20
JournalAmerican Journal of Translational Research
Volume9
Issue number10
StatePublished - 2017

Fingerprint

Tendons
Rotator Cuff
Therapeutics
Pain
Tendinopathy
Mechanical Stress
Tears
Health care
Health Care Costs
Extracellular Matrix
Rupture
Collagen
Apoptosis
Wounds and Injuries
Chemical analysis

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Clinical Biochemistry
  • Cancer Research

Cite this

Alterations in tendon microenvironment in response to mechanical load : Potential molecular targets for treatment strategies. / Fouda, Mohamed B.; Thankam, Finosh G.; Dilisio, Matthew; Agrawal, Devendra K.

In: American Journal of Translational Research, Vol. 9, No. 10, AJTR0059913, 2017, p. 4341-4360.

Research output: Contribution to journalReview article

@article{2a94cb78701d4e518655d5e656e93d5e,
title = "Alterations in tendon microenvironment in response to mechanical load: Potential molecular targets for treatment strategies",
abstract = "Rotator cuff (RC) tendons could beinflicted in many ways with an eventual outcome of pain, weakness and disability, which represent a large burden on health care cost. However, optimal healing, either conservatively or with surgical intervention, remains an issue that needs further investigation. Disorders of the RC tendons may result from external factors like trauma, or internal factors through physiologic and metabolic derangement. Most RC tendon disorders may be asymptomatic and may result from an over-activity of the inflicted shoulder and its tendons. Such tendon disorders are poorly diagnosed since patients do not seek medical attention until pain or weakness ensue. Immunological and biochemical events in RC disorders due to mechanical intolerance have not been investigated. Generally, the mechanical load drives normal physiological properties of the tendon. But, mechanical overload/burden exerts stress on tenocytes, and disrupts the tendon microenvironment by triggering a multitude of signaling pathways leading to extracellular matrix remodeling, disorganization, alteration in collagen composition and apoptosis. These events result in weak tendon which is highly susceptible to rupture or tear. In this article, we critically reviewed the intrinsic signaling pathways that are excessively triggered by continuous mechanical load and the counteracting physiological responses and associated derangements. The elucidation of the molecular events underlying mechanical stress-induced symptomatic/asymptomatic tendinopathy could provide information on potential target sites for translational application in the management of rotator cuff disorders.",
author = "Fouda, {Mohamed B.} and Thankam, {Finosh G.} and Matthew Dilisio and Agrawal, {Devendra K.}",
year = "2017",
language = "English (US)",
volume = "9",
pages = "4341--4360",
journal = "American Journal of Translational Research",
issn = "1943-8141",
publisher = "e-Century Publishing Corporation",
number = "10",

}

TY - JOUR

T1 - Alterations in tendon microenvironment in response to mechanical load

T2 - Potential molecular targets for treatment strategies

AU - Fouda, Mohamed B.

AU - Thankam, Finosh G.

AU - Dilisio, Matthew

AU - Agrawal, Devendra K.

PY - 2017

Y1 - 2017

N2 - Rotator cuff (RC) tendons could beinflicted in many ways with an eventual outcome of pain, weakness and disability, which represent a large burden on health care cost. However, optimal healing, either conservatively or with surgical intervention, remains an issue that needs further investigation. Disorders of the RC tendons may result from external factors like trauma, or internal factors through physiologic and metabolic derangement. Most RC tendon disorders may be asymptomatic and may result from an over-activity of the inflicted shoulder and its tendons. Such tendon disorders are poorly diagnosed since patients do not seek medical attention until pain or weakness ensue. Immunological and biochemical events in RC disorders due to mechanical intolerance have not been investigated. Generally, the mechanical load drives normal physiological properties of the tendon. But, mechanical overload/burden exerts stress on tenocytes, and disrupts the tendon microenvironment by triggering a multitude of signaling pathways leading to extracellular matrix remodeling, disorganization, alteration in collagen composition and apoptosis. These events result in weak tendon which is highly susceptible to rupture or tear. In this article, we critically reviewed the intrinsic signaling pathways that are excessively triggered by continuous mechanical load and the counteracting physiological responses and associated derangements. The elucidation of the molecular events underlying mechanical stress-induced symptomatic/asymptomatic tendinopathy could provide information on potential target sites for translational application in the management of rotator cuff disorders.

AB - Rotator cuff (RC) tendons could beinflicted in many ways with an eventual outcome of pain, weakness and disability, which represent a large burden on health care cost. However, optimal healing, either conservatively or with surgical intervention, remains an issue that needs further investigation. Disorders of the RC tendons may result from external factors like trauma, or internal factors through physiologic and metabolic derangement. Most RC tendon disorders may be asymptomatic and may result from an over-activity of the inflicted shoulder and its tendons. Such tendon disorders are poorly diagnosed since patients do not seek medical attention until pain or weakness ensue. Immunological and biochemical events in RC disorders due to mechanical intolerance have not been investigated. Generally, the mechanical load drives normal physiological properties of the tendon. But, mechanical overload/burden exerts stress on tenocytes, and disrupts the tendon microenvironment by triggering a multitude of signaling pathways leading to extracellular matrix remodeling, disorganization, alteration in collagen composition and apoptosis. These events result in weak tendon which is highly susceptible to rupture or tear. In this article, we critically reviewed the intrinsic signaling pathways that are excessively triggered by continuous mechanical load and the counteracting physiological responses and associated derangements. The elucidation of the molecular events underlying mechanical stress-induced symptomatic/asymptomatic tendinopathy could provide information on potential target sites for translational application in the management of rotator cuff disorders.

UR - http://www.scopus.com/inward/record.url?scp=85032660046&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85032660046&partnerID=8YFLogxK

M3 - Review article

AN - SCOPUS:85032660046

VL - 9

SP - 4341

EP - 4360

JO - American Journal of Translational Research

JF - American Journal of Translational Research

SN - 1943-8141

IS - 10

M1 - AJTR0059913

ER -