Aminoglycoside levels in critically ill surgical patients: The implications of physiologic criteria of sepsis

Edward E. Cornwell, Howard Belzberg, Thomas V. Berne, Jack W. Kern, Gavin Henriques, Juan A. Asensio, Demetrios Demetriades

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

We retrospectively reviewed medical records and computerized critical care data for 40 consecutive critically ill surgical patients receiving 'standard' doses (1.5 to 2.0 mg/kg loading dose and 3 to 5 mg/kg/day) of gentamicin or tobramycin for gram-negative infections. End points measured were serum drug levels and clearance of infection. Therapeutic serum aminoglycoside levels were achieved within 48 hours of therapy by only 7 patients (17.5%). Among the remaining 38 patients, significantly fewer septic than nonseptic patients had clearance of their infection (11% vs 92%). Specific physiologic criteria of sepsis may be used to identify critically ill patients who will most likely benefit from aggressive initial aminoglycoside dosing when these drugs are used to treat gram-negative infections.

Original languageEnglish (US)
Pages (from-to)33-36
Number of pages4
JournalSouthern Medical Journal
Volume90
Issue number1
DOIs
StatePublished - Jan 1997
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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