Abstract
We retrospectively reviewed medical records and computerized critical care data for 40 consecutive critically ill surgical patients receiving 'standard' doses (1.5 to 2.0 mg/kg loading dose and 3 to 5 mg/kg/day) of gentamicin or tobramycin for gram-negative infections. End points measured were serum drug levels and clearance of infection. Therapeutic serum aminoglycoside levels were achieved within 48 hours of therapy by only 7 patients (17.5%). Among the remaining 38 patients, significantly fewer septic than nonseptic patients had clearance of their infection (11% vs 92%). Specific physiologic criteria of sepsis may be used to identify critically ill patients who will most likely benefit from aggressive initial aminoglycoside dosing when these drugs are used to treat gram-negative infections.
| Original language | English |
|---|---|
| Pages (from-to) | 33-36 |
| Number of pages | 4 |
| Journal | Southern Medical Journal |
| Volume | 90 |
| Issue number | 1 |
| State | Published - Jan 1997 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Medicine(all)
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Aminoglycoside levels in critically ill surgical patients : The implications of physiologic criteria of sepsis. / Cornwell, Edward E.; Belzberg, Howard; Berne, Thomas V.; Kern, Jack W.; Henriques, Gavin; Asensio, Juan A.; Demetriades, Demetrios.
In: Southern Medical Journal, Vol. 90, No. 1, 01.1997, p. 33-36.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Aminoglycoside levels in critically ill surgical patients
T2 - The implications of physiologic criteria of sepsis
AU - Cornwell, Edward E.
AU - Belzberg, Howard
AU - Berne, Thomas V.
AU - Kern, Jack W.
AU - Henriques, Gavin
AU - Asensio, Juan A.
AU - Demetriades, Demetrios
PY - 1997/1
Y1 - 1997/1
N2 - We retrospectively reviewed medical records and computerized critical care data for 40 consecutive critically ill surgical patients receiving 'standard' doses (1.5 to 2.0 mg/kg loading dose and 3 to 5 mg/kg/day) of gentamicin or tobramycin for gram-negative infections. End points measured were serum drug levels and clearance of infection. Therapeutic serum aminoglycoside levels were achieved within 48 hours of therapy by only 7 patients (17.5%). Among the remaining 38 patients, significantly fewer septic than nonseptic patients had clearance of their infection (11% vs 92%). Specific physiologic criteria of sepsis may be used to identify critically ill patients who will most likely benefit from aggressive initial aminoglycoside dosing when these drugs are used to treat gram-negative infections.
AB - We retrospectively reviewed medical records and computerized critical care data for 40 consecutive critically ill surgical patients receiving 'standard' doses (1.5 to 2.0 mg/kg loading dose and 3 to 5 mg/kg/day) of gentamicin or tobramycin for gram-negative infections. End points measured were serum drug levels and clearance of infection. Therapeutic serum aminoglycoside levels were achieved within 48 hours of therapy by only 7 patients (17.5%). Among the remaining 38 patients, significantly fewer septic than nonseptic patients had clearance of their infection (11% vs 92%). Specific physiologic criteria of sepsis may be used to identify critically ill patients who will most likely benefit from aggressive initial aminoglycoside dosing when these drugs are used to treat gram-negative infections.
UR - http://www.scopus.com/inward/record.url?scp=0031017559&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031017559&partnerID=8YFLogxK
M3 - Article
C2 - 9003820
AN - SCOPUS:0031017559
VL - 90
SP - 33
EP - 36
JO - Southern Medical Journal
JF - Southern Medical Journal
SN - 0038-4348
IS - 1
ER -