Abstract
Objectives This prospective, randomized, double-blind, placebo-controlled study compared the efficacy and safety of amiodarone and sotalol in the prevention of atrial fibrillation (AF) following open heart surgery. Background The incidence of supraventricular arrhythmias following open heart surgery ranges from 20% to 40%, with AF being the most common. Both amiodarone and sotalol have been shown to be effective in reducing postoperative arrhythmias, but no direct comparison of these agents has been conducted. Methods A total of 160 patients were randomized, of whom 134 underwent coronary artery bypass graft surgery (CABG) alone, 17 underwent CABG and concomitant aortic valve replacement surgery (AVR), 9 underwent AVR only, and 1 patient's surgery was canceled. Patients with signs or symptoms of congestive heart failure (CHF), ejection fraction ≤30%, estimated creatinine clearance
| Original language | English |
|---|---|
| Pages (from-to) | 641-648 |
| Number of pages | 8 |
| Journal | American Heart Journal |
| Volume | 148 |
| Issue number | 4 |
| DOIs | |
| State | Published - Oct 2004 |
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All Science Journal Classification (ASJC) codes
- Cardiology and Cardiovascular Medicine
Cite this
Amiodarone versus sotalol for the treatment of atrial fibrillation after open heart surgery : The Reduction in Postoperative Cardiovascular Arrhythmic Events (REDUCE) trial. / Mooss, Aryan N.; Wurdeman, Richard L.; Sugimoto, Jeffrey T.; Packard, Kathleen A.; Hilleman, Daniel E.; Lenz, Thomas L.; Rovang, Karen S.; Arcidi, Joseph M.; Mohiuddin, Syed M.
In: American Heart Journal, Vol. 148, No. 4, 10.2004, p. 641-648.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Amiodarone versus sotalol for the treatment of atrial fibrillation after open heart surgery
T2 - The Reduction in Postoperative Cardiovascular Arrhythmic Events (REDUCE) trial
AU - Mooss, Aryan N.
AU - Wurdeman, Richard L.
AU - Sugimoto, Jeffrey T.
AU - Packard, Kathleen A.
AU - Hilleman, Daniel E.
AU - Lenz, Thomas L.
AU - Rovang, Karen S.
AU - Arcidi, Joseph M.
AU - Mohiuddin, Syed M.
PY - 2004/10
Y1 - 2004/10
N2 - Objectives This prospective, randomized, double-blind, placebo-controlled study compared the efficacy and safety of amiodarone and sotalol in the prevention of atrial fibrillation (AF) following open heart surgery. Background The incidence of supraventricular arrhythmias following open heart surgery ranges from 20% to 40%, with AF being the most common. Both amiodarone and sotalol have been shown to be effective in reducing postoperative arrhythmias, but no direct comparison of these agents has been conducted. Methods A total of 160 patients were randomized, of whom 134 underwent coronary artery bypass graft surgery (CABG) alone, 17 underwent CABG and concomitant aortic valve replacement surgery (AVR), 9 underwent AVR only, and 1 patient's surgery was canceled. Patients with signs or symptoms of congestive heart failure (CHF), ejection fraction ≤30%, estimated creatinine clearance
AB - Objectives This prospective, randomized, double-blind, placebo-controlled study compared the efficacy and safety of amiodarone and sotalol in the prevention of atrial fibrillation (AF) following open heart surgery. Background The incidence of supraventricular arrhythmias following open heart surgery ranges from 20% to 40%, with AF being the most common. Both amiodarone and sotalol have been shown to be effective in reducing postoperative arrhythmias, but no direct comparison of these agents has been conducted. Methods A total of 160 patients were randomized, of whom 134 underwent coronary artery bypass graft surgery (CABG) alone, 17 underwent CABG and concomitant aortic valve replacement surgery (AVR), 9 underwent AVR only, and 1 patient's surgery was canceled. Patients with signs or symptoms of congestive heart failure (CHF), ejection fraction ≤30%, estimated creatinine clearance
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UR - http://www.scopus.com/inward/citedby.url?scp=5344274546&partnerID=8YFLogxK
U2 - 10.1016/j.ahj.2004.04.031
DO - 10.1016/j.ahj.2004.04.031
M3 - Article
VL - 148
SP - 641
EP - 648
JO - American Heart Journal
JF - American Heart Journal
SN - 0002-8703
IS - 4
ER -