Amiodarone versus sotalol for the treatment of atrial fibrillation after open heart surgery

The Reduction in Postoperative Cardiovascular Arrhythmic Events (REDUCE) trial

Aryan N. Mooss, Richard L. Wurdeman, Jeffrey T. Sugimoto, Kathleen A. Packard, Daniel E. Hilleman, Thomas L. Lenz, Karen S. Rovang, Joseph M. Arcidi, Syed M. Mohiuddin

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Objectives This prospective, randomized, double-blind, placebo-controlled study compared the efficacy and safety of amiodarone and sotalol in the prevention of atrial fibrillation (AF) following open heart surgery. Background The incidence of supraventricular arrhythmias following open heart surgery ranges from 20% to 40%, with AF being the most common. Both amiodarone and sotalol have been shown to be effective in reducing postoperative arrhythmias, but no direct comparison of these agents has been conducted. Methods A total of 160 patients were randomized, of whom 134 underwent coronary artery bypass graft surgery (CABG) alone, 17 underwent CABG and concomitant aortic valve replacement surgery (AVR), 9 underwent AVR only, and 1 patient's surgery was canceled. Patients with signs or symptoms of congestive heart failure (CHF), ejection fraction ≤30%, estimated creatinine clearance

Original languageEnglish
Pages (from-to)641-648
Number of pages8
JournalAmerican Heart Journal
Volume148
Issue number4
DOIs
StatePublished - Oct 2004

Fingerprint

Sotalol
Amiodarone
Atrial Fibrillation
Thoracic Surgery
Aortic Valve
Coronary Artery Bypass
Cardiac Arrhythmias
Transplants
Signs and Symptoms
Creatinine
Therapeutics
Heart Failure
Placebos
Safety
Incidence

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

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title = "Amiodarone versus sotalol for the treatment of atrial fibrillation after open heart surgery: The Reduction in Postoperative Cardiovascular Arrhythmic Events (REDUCE) trial",
abstract = "Objectives This prospective, randomized, double-blind, placebo-controlled study compared the efficacy and safety of amiodarone and sotalol in the prevention of atrial fibrillation (AF) following open heart surgery. Background The incidence of supraventricular arrhythmias following open heart surgery ranges from 20{\%} to 40{\%}, with AF being the most common. Both amiodarone and sotalol have been shown to be effective in reducing postoperative arrhythmias, but no direct comparison of these agents has been conducted. Methods A total of 160 patients were randomized, of whom 134 underwent coronary artery bypass graft surgery (CABG) alone, 17 underwent CABG and concomitant aortic valve replacement surgery (AVR), 9 underwent AVR only, and 1 patient's surgery was canceled. Patients with signs or symptoms of congestive heart failure (CHF), ejection fraction ≤30{\%}, estimated creatinine clearance",
author = "Mooss, {Aryan N.} and Wurdeman, {Richard L.} and Sugimoto, {Jeffrey T.} and Packard, {Kathleen A.} and Hilleman, {Daniel E.} and Lenz, {Thomas L.} and Rovang, {Karen S.} and Arcidi, {Joseph M.} and Mohiuddin, {Syed M.}",
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T1 - Amiodarone versus sotalol for the treatment of atrial fibrillation after open heart surgery

T2 - The Reduction in Postoperative Cardiovascular Arrhythmic Events (REDUCE) trial

AU - Mooss, Aryan N.

AU - Wurdeman, Richard L.

AU - Sugimoto, Jeffrey T.

AU - Packard, Kathleen A.

AU - Hilleman, Daniel E.

AU - Lenz, Thomas L.

AU - Rovang, Karen S.

AU - Arcidi, Joseph M.

AU - Mohiuddin, Syed M.

PY - 2004/10

Y1 - 2004/10

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AB - Objectives This prospective, randomized, double-blind, placebo-controlled study compared the efficacy and safety of amiodarone and sotalol in the prevention of atrial fibrillation (AF) following open heart surgery. Background The incidence of supraventricular arrhythmias following open heart surgery ranges from 20% to 40%, with AF being the most common. Both amiodarone and sotalol have been shown to be effective in reducing postoperative arrhythmias, but no direct comparison of these agents has been conducted. Methods A total of 160 patients were randomized, of whom 134 underwent coronary artery bypass graft surgery (CABG) alone, 17 underwent CABG and concomitant aortic valve replacement surgery (AVR), 9 underwent AVR only, and 1 patient's surgery was canceled. Patients with signs or symptoms of congestive heart failure (CHF), ejection fraction ≤30%, estimated creatinine clearance

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