AmpC and OprD are not involved in the mechanism of imipenem hypersusceptibility among Pseudomonas aeruginosa isolates overexpressing the mexCD-oprJ efflux pump

Daniel J. Wolter, Nancy D. Hanson, Philip D. Lister

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Pseudomonas aeruginosa strains that overexpress mexCD-oprJ become hypersusceptible to imipenem. Disruption of AmpC induction has been suggested to cause this phenotype. However, data from this study demonstrate that hypersusceptibility to imipenem can develop without changes in ampC expression or AmpC activity. Furthermore, hypersusceptibility is not caused by changes in expression of the outer membrane porin, OprD.

Original languageEnglish
Pages (from-to)4763-4766
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
Volume49
Issue number11
DOIs
StatePublished - Nov 2005

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Imipenem
Pseudomonas aeruginosa
Porins
Phenotype
Membranes

All Science Journal Classification (ASJC) codes

  • Pharmacology (medical)

Cite this

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abstract = "Pseudomonas aeruginosa strains that overexpress mexCD-oprJ become hypersusceptible to imipenem. Disruption of AmpC induction has been suggested to cause this phenotype. However, data from this study demonstrate that hypersusceptibility to imipenem can develop without changes in ampC expression or AmpC activity. Furthermore, hypersusceptibility is not caused by changes in expression of the outer membrane porin, OprD.",
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AU - Lister, Philip D.

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AB - Pseudomonas aeruginosa strains that overexpress mexCD-oprJ become hypersusceptible to imipenem. Disruption of AmpC induction has been suggested to cause this phenotype. However, data from this study demonstrate that hypersusceptibility to imipenem can develop without changes in ampC expression or AmpC activity. Furthermore, hypersusceptibility is not caused by changes in expression of the outer membrane porin, OprD.

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