AmpC and OprD are not involved in the mechanism of imipenem hypersusceptibility among Pseudomonas aeruginosa isolates overexpressing the mexCD-oprJ efflux pump

Daniel J. Wolter, Nancy D. Hanson, Philip D. Lister

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Abstract

Pseudomonas aeruginosa strains that overexpress mexCD-oprJ become hypersusceptible to imipenem. Disruption of AmpC induction has been suggested to cause this phenotype. However, data from this study demonstrate that hypersusceptibility to imipenem can develop without changes in ampC expression or AmpC activity. Furthermore, hypersusceptibility is not caused by changes in expression of the outer membrane porin, OprD.

Original languageEnglish
Pages (from-to)4763-4766
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
Volume49
Issue number11
DOIs
Publication statusPublished - Nov 2005

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All Science Journal Classification (ASJC) codes

  • Pharmacology (medical)

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