Abstract
Context: Decreased calcitriol production due to impaired renal function may be a significant risk factor for falls in normal aging population. Objective: The objective of the study was to examine the association between creatinine clearance (CrCl) and the incidence of falls and fallers in groups treated with placebo, calcitriol, estrogen therapy (ET)/estrogen + progestin therapy (HT), and calcitriol + ET/HT. Design: This was a 3-yr, double-blind, placebo-controlled study designed to test the efficacy of calcitriol and ET/HT on bone loss and falls with analysis by intention to treat and post hoc. Setting: The study was conducted at an academic outpatient center. Participants: Four hundred eighty-nine normal elderly women aged 65-77 yr; 415 women completed the study. Intervention: Subjects were randomized to placebo, calcitriol 0.25 μg twice a day, ET daily (conjugated equine estrogens 0.625 mg), HT (conjugated equine estrogen 0.625 mg + medroxyprogesterone acetate 2.5 mg) and calcitriol + ET/HT. Main Outcome Measures: Cumulative number of falls and fallers were compared between groups with 24-h urine CrCl less than 60 and 60 ml/min or greater. Results: Calcitriol treatment decreased the number of fallers and falls. Low CrCl less than 60 ml/min was a predictor of the number of falls per person but not fallers in the placebo group (P = 0.007). In the low CrCl group (
| Original language | English |
|---|---|
| Pages (from-to) | 51-58 |
| Number of pages | 8 |
| Journal | Journal of Clinical Endocrinology and Metabolism |
| Volume | 92 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 2007 |
Fingerprint
All Science Journal Classification (ASJC) codes
- Biochemistry
- Endocrinology, Diabetes and Metabolism
Cite this
An age-related decrease in creatinine clearance is associated with an increase in number of falls in untreated women but not in women receiving calcitriol treatment. / Gallagher, John Christopher G.; Rapuri, Prema B.; Smith, Lynette M.
In: Journal of Clinical Endocrinology and Metabolism, Vol. 92, No. 1, 01.2007, p. 51-58.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - An age-related decrease in creatinine clearance is associated with an increase in number of falls in untreated women but not in women receiving calcitriol treatment
AU - Gallagher, John Christopher G.
AU - Rapuri, Prema B.
AU - Smith, Lynette M.
PY - 2007/1
Y1 - 2007/1
N2 - Context: Decreased calcitriol production due to impaired renal function may be a significant risk factor for falls in normal aging population. Objective: The objective of the study was to examine the association between creatinine clearance (CrCl) and the incidence of falls and fallers in groups treated with placebo, calcitriol, estrogen therapy (ET)/estrogen + progestin therapy (HT), and calcitriol + ET/HT. Design: This was a 3-yr, double-blind, placebo-controlled study designed to test the efficacy of calcitriol and ET/HT on bone loss and falls with analysis by intention to treat and post hoc. Setting: The study was conducted at an academic outpatient center. Participants: Four hundred eighty-nine normal elderly women aged 65-77 yr; 415 women completed the study. Intervention: Subjects were randomized to placebo, calcitriol 0.25 μg twice a day, ET daily (conjugated equine estrogens 0.625 mg), HT (conjugated equine estrogen 0.625 mg + medroxyprogesterone acetate 2.5 mg) and calcitriol + ET/HT. Main Outcome Measures: Cumulative number of falls and fallers were compared between groups with 24-h urine CrCl less than 60 and 60 ml/min or greater. Results: Calcitriol treatment decreased the number of fallers and falls. Low CrCl less than 60 ml/min was a predictor of the number of falls per person but not fallers in the placebo group (P = 0.007). In the low CrCl group (
AB - Context: Decreased calcitriol production due to impaired renal function may be a significant risk factor for falls in normal aging population. Objective: The objective of the study was to examine the association between creatinine clearance (CrCl) and the incidence of falls and fallers in groups treated with placebo, calcitriol, estrogen therapy (ET)/estrogen + progestin therapy (HT), and calcitriol + ET/HT. Design: This was a 3-yr, double-blind, placebo-controlled study designed to test the efficacy of calcitriol and ET/HT on bone loss and falls with analysis by intention to treat and post hoc. Setting: The study was conducted at an academic outpatient center. Participants: Four hundred eighty-nine normal elderly women aged 65-77 yr; 415 women completed the study. Intervention: Subjects were randomized to placebo, calcitriol 0.25 μg twice a day, ET daily (conjugated equine estrogens 0.625 mg), HT (conjugated equine estrogen 0.625 mg + medroxyprogesterone acetate 2.5 mg) and calcitriol + ET/HT. Main Outcome Measures: Cumulative number of falls and fallers were compared between groups with 24-h urine CrCl less than 60 and 60 ml/min or greater. Results: Calcitriol treatment decreased the number of fallers and falls. Low CrCl less than 60 ml/min was a predictor of the number of falls per person but not fallers in the placebo group (P = 0.007). In the low CrCl group (
UR - http://www.scopus.com/inward/record.url?scp=33846077677&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33846077677&partnerID=8YFLogxK
U2 - 10.1210/jc.2006-1153
DO - 10.1210/jc.2006-1153
M3 - Article
C2 - 17032712
AN - SCOPUS:33846077677
VL - 92
SP - 51
EP - 58
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
SN - 0021-972X
IS - 1
ER -