An inositol phosphate as a calcium absorption enhancer in rats

Xin Shen; Connie M. Weaver; Anna Kempa-Steczko; Berdine R. Martin; Brian Q. Phillippy; Robert P. Heaney

doi:10.1016/S0955-2863(98)00020-5

An inositol phosphate as a calcium absorption enhancer in rats

Xin Shen, Connie M. Weaver, Anna Kempa-Steczko, Berdine R. Martin, Brian Q. Phillippy, Robert P. Heaney

Department of Medicine

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Certain inositol phosphate breakdown compounds have been shown to chelate and increase the solubility of minerals. A rat model using femur uptake of ⁴⁵Ca was tested for its ability to screen the effect of inositol phosphytate breakdown products on enhancing calcium absorption. Phytate was shown to inhibit calcium absorption in a dose-related manner. A significant enhancing effect of 1,2,3,6-tetraphosphate on calcium absorption was found at the highest level studies (P <0.05), which suggests that this compound may ne a candidate for enhancing calcium absorption.

Original language	English (US)
Pages (from-to)	298-301
Number of pages	4
Journal	Journal of Nutritional Biochemistry
Volume	9
Issue number	5
DOIs	https://doi.org/10.1016/S0955-2863(98)00020-5
State	Published - May 1998

All Science Journal Classification (ASJC) codes

Endocrinology, Diabetes and Metabolism
Biochemistry
Molecular Biology
Nutrition and Dietetics
Clinical Biochemistry

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10.1016/S0955-2863(98)00020-5

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title = "An inositol phosphate as a calcium absorption enhancer in rats",

abstract = "Certain inositol phosphate breakdown compounds have been shown to chelate and increase the solubility of minerals. A rat model using femur uptake of 45Ca was tested for its ability to screen the effect of inositol phosphytate breakdown products on enhancing calcium absorption. Phytate was shown to inhibit calcium absorption in a dose-related manner. A significant enhancing effect of 1,2,3,6-tetraphosphate on calcium absorption was found at the highest level studies (P <0.05), which suggests that this compound may ne a candidate for enhancing calcium absorption.",

author = "Xin Shen and Weaver, {Connie M.} and Anna Kempa-Steczko and Martin, {Berdine R.} and Phillippy, {Brian Q.} and Heaney, {Robert P.}",

note = "Funding Information: This research was supported by PHS Grant 39221.",

year = "1998",

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T1 - An inositol phosphate as a calcium absorption enhancer in rats

AU - Shen, Xin

AU - Weaver, Connie M.

AU - Kempa-Steczko, Anna

AU - Martin, Berdine R.

AU - Phillippy, Brian Q.

AU - Heaney, Robert P.

N1 - Funding Information: This research was supported by PHS Grant 39221.

PY - 1998/5

Y1 - 1998/5

N2 - Certain inositol phosphate breakdown compounds have been shown to chelate and increase the solubility of minerals. A rat model using femur uptake of 45Ca was tested for its ability to screen the effect of inositol phosphytate breakdown products on enhancing calcium absorption. Phytate was shown to inhibit calcium absorption in a dose-related manner. A significant enhancing effect of 1,2,3,6-tetraphosphate on calcium absorption was found at the highest level studies (P <0.05), which suggests that this compound may ne a candidate for enhancing calcium absorption.

AB - Certain inositol phosphate breakdown compounds have been shown to chelate and increase the solubility of minerals. A rat model using femur uptake of 45Ca was tested for its ability to screen the effect of inositol phosphytate breakdown products on enhancing calcium absorption. Phytate was shown to inhibit calcium absorption in a dose-related manner. A significant enhancing effect of 1,2,3,6-tetraphosphate on calcium absorption was found at the highest level studies (P <0.05), which suggests that this compound may ne a candidate for enhancing calcium absorption.

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An inositol phosphate as a calcium absorption enhancer in rats

Abstract

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