An inositol phosphate as a calcium absorption enhancer in rats

Xin Shen; Connie M. Weaver; Anna Kempa-Steczko; Berdine R. Martin; Brian Q. Phillippy; Robert P. Heaney

doi:10.1016/S0955-2863(98)00020-5

An inositol phosphate as a calcium absorption enhancer in rats

Xin Shen, Connie M. Weaver, Anna Kempa-Steczko, Berdine R. Martin, Brian Q. Phillippy, Robert P. Heaney

Department of Medicine

Research output: Contribution to journal › Article

14 Scopus citations

Abstract

Certain inositol phosphate breakdown compounds have been shown to chelate and increase the solubility of minerals. A rat model using femur uptake of ⁴⁵Ca was tested for its ability to screen the effect of inositol phosphytate breakdown products on enhancing calcium absorption. Phytate was shown to inhibit calcium absorption in a dose-related manner. A significant enhancing effect of 1,2,3,6-tetraphosphate on calcium absorption was found at the highest level studies (P <0.05), which suggests that this compound may ne a candidate for enhancing calcium absorption.

Original language	English
Pages (from-to)	298-301
Number of pages	4
Journal	Journal of Nutritional Biochemistry
Volume	9
Issue number	5
DOIs	https://doi.org/10.1016/S0955-2863(98)00020-5
Publication status	Published - May 1998

Fingerprint

All Science Journal Classification (ASJC) codes

Biochemistry
Endocrinology, Diabetes and Metabolism

Cite this

Shen, X., Weaver, C. M., Kempa-Steczko, A., Martin, B. R., Phillippy, B. Q., & Heaney, R. P. (1998). An inositol phosphate as a calcium absorption enhancer in rats. Journal of Nutritional Biochemistry, 9(5), 298-301. https://doi.org/10.1016/S0955-2863(98)00020-5

@article{2ab1574e5ad34369b2f1732071c270b6,

title = "An inositol phosphate as a calcium absorption enhancer in rats",

abstract = "Certain inositol phosphate breakdown compounds have been shown to chelate and increase the solubility of minerals. A rat model using femur uptake of 45Ca was tested for its ability to screen the effect of inositol phosphytate breakdown products on enhancing calcium absorption. Phytate was shown to inhibit calcium absorption in a dose-related manner. A significant enhancing effect of 1,2,3,6-tetraphosphate on calcium absorption was found at the highest level studies (P <0.05), which suggests that this compound may ne a candidate for enhancing calcium absorption.",

author = "Xin Shen and Weaver, {Connie M.} and Anna Kempa-Steczko and Martin, {Berdine R.} and Phillippy, {Brian Q.} and Heaney, {Robert P.}",

year = "1998",

month = "5",

doi = "10.1016/S0955-2863(98)00020-5",

language = "English",

volume = "9",

pages = "298--301",

journal = "Journal of Nutritional Biochemistry",

issn = "0955-2863",

publisher = "Elsevier Inc.",

number = "5",

}

TY - JOUR

T1 - An inositol phosphate as a calcium absorption enhancer in rats

AU - Shen, Xin

AU - Weaver, Connie M.

AU - Kempa-Steczko, Anna

AU - Martin, Berdine R.

AU - Phillippy, Brian Q.

AU - Heaney, Robert P.

PY - 1998/5

Y1 - 1998/5

N2 - Certain inositol phosphate breakdown compounds have been shown to chelate and increase the solubility of minerals. A rat model using femur uptake of 45Ca was tested for its ability to screen the effect of inositol phosphytate breakdown products on enhancing calcium absorption. Phytate was shown to inhibit calcium absorption in a dose-related manner. A significant enhancing effect of 1,2,3,6-tetraphosphate on calcium absorption was found at the highest level studies (P <0.05), which suggests that this compound may ne a candidate for enhancing calcium absorption.

AB - Certain inositol phosphate breakdown compounds have been shown to chelate and increase the solubility of minerals. A rat model using femur uptake of 45Ca was tested for its ability to screen the effect of inositol phosphytate breakdown products on enhancing calcium absorption. Phytate was shown to inhibit calcium absorption in a dose-related manner. A significant enhancing effect of 1,2,3,6-tetraphosphate on calcium absorption was found at the highest level studies (P <0.05), which suggests that this compound may ne a candidate for enhancing calcium absorption.

UR - http://www.scopus.com/inward/record.url?scp=0032078188&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032078188&partnerID=8YFLogxK

U2 - 10.1016/S0955-2863(98)00020-5

DO - 10.1016/S0955-2863(98)00020-5

M3 - Article

AN - SCOPUS:0032078188

VL - 9

SP - 298

EP - 301

JO - Journal of Nutritional Biochemistry

JF - Journal of Nutritional Biochemistry

SN - 0955-2863

IS - 5

ER -

Access to Document

10.1016/S0955-2863(98)00020-5