An update on DNA-based BRCA1/BRCA2 genetic counseling in hereditary breast cancer

Henry T. Lynch, Patrice Watson, Susan Tinley, Carrie Snyder, Carolyn Durham, Jane Lynch, Yulia Kirnarsky, Olga Serova, Gilbert Lenoir, Caryn Lerman, Steven A. Narod

Research output: Contribution to journalArticle

69 Citations (Scopus)

Abstract

The identification of BRCA1 and BRCA2 mutations has enabled physicians to identify persons at high risk for carcinoma of the breast and ovary in hereditary breast-ovarian cancer (HBOC) families. Many physicians have limited knowledge about the effective translation of these new discoveries into clinical practice settings. This problem is further confounded by the limited number of genetic counselors who have experience with cancer genetics. Genetic counseling about DNA test results was provided to 420 patients from 37 HBC/HBOC families. Descriptive data were collected and recorded about their responses to questions posed immediately before and after test results were disclosed. Findings disclosed a significant tendency of patients to overestimate rather than underestimate their risk (P <.001) prior to receiving results. The chief reason for declining to receive results was fear of insurance discrimination. The primary reason that patients sought test results was for their children. Most women reported that, if testing identified them as mutation carriers, they would consider lifetime surveillance and prophylactic surgery. Responses to DNA test results were varied and often unpredictable. Counseling by an appropriately educated and skilled professional is essential to assist people in making decisions regarding testing and health management.

Original languageEnglish
Pages (from-to)91-98
Number of pages8
JournalCancer Genetics and Cytogenetics
Volume109
Issue number2
DOIs
StatePublished - Mar 1999

Fingerprint

Genetic Counseling
Breast Neoplasms
Ovarian Neoplasms
DNA
Physicians
Mutation
Insurance
Fear
Counseling
Ovary
Decision Making
Health
Neoplasms

All Science Journal Classification (ASJC) codes

  • Cancer Research
  • Genetics
  • Molecular Biology

Cite this

An update on DNA-based BRCA1/BRCA2 genetic counseling in hereditary breast cancer. / Lynch, Henry T.; Watson, Patrice; Tinley, Susan; Snyder, Carrie; Durham, Carolyn; Lynch, Jane; Kirnarsky, Yulia; Serova, Olga; Lenoir, Gilbert; Lerman, Caryn; Narod, Steven A.

In: Cancer Genetics and Cytogenetics, Vol. 109, No. 2, 03.1999, p. 91-98.

Research output: Contribution to journalArticle

Lynch, HT, Watson, P, Tinley, S, Snyder, C, Durham, C, Lynch, J, Kirnarsky, Y, Serova, O, Lenoir, G, Lerman, C & Narod, SA 1999, 'An update on DNA-based BRCA1/BRCA2 genetic counseling in hereditary breast cancer', Cancer Genetics and Cytogenetics, vol. 109, no. 2, pp. 91-98. https://doi.org/10.1016/S0165-4608(98)00165-4
Lynch, Henry T. ; Watson, Patrice ; Tinley, Susan ; Snyder, Carrie ; Durham, Carolyn ; Lynch, Jane ; Kirnarsky, Yulia ; Serova, Olga ; Lenoir, Gilbert ; Lerman, Caryn ; Narod, Steven A. / An update on DNA-based BRCA1/BRCA2 genetic counseling in hereditary breast cancer. In: Cancer Genetics and Cytogenetics. 1999 ; Vol. 109, No. 2. pp. 91-98.
@article{c6b370ea11434c0ba80d35d4d8860d5a,
title = "An update on DNA-based BRCA1/BRCA2 genetic counseling in hereditary breast cancer",
abstract = "The identification of BRCA1 and BRCA2 mutations has enabled physicians to identify persons at high risk for carcinoma of the breast and ovary in hereditary breast-ovarian cancer (HBOC) families. Many physicians have limited knowledge about the effective translation of these new discoveries into clinical practice settings. This problem is further confounded by the limited number of genetic counselors who have experience with cancer genetics. Genetic counseling about DNA test results was provided to 420 patients from 37 HBC/HBOC families. Descriptive data were collected and recorded about their responses to questions posed immediately before and after test results were disclosed. Findings disclosed a significant tendency of patients to overestimate rather than underestimate their risk (P <.001) prior to receiving results. The chief reason for declining to receive results was fear of insurance discrimination. The primary reason that patients sought test results was for their children. Most women reported that, if testing identified them as mutation carriers, they would consider lifetime surveillance and prophylactic surgery. Responses to DNA test results were varied and often unpredictable. Counseling by an appropriately educated and skilled professional is essential to assist people in making decisions regarding testing and health management.",
author = "Lynch, {Henry T.} and Patrice Watson and Susan Tinley and Carrie Snyder and Carolyn Durham and Jane Lynch and Yulia Kirnarsky and Olga Serova and Gilbert Lenoir and Caryn Lerman and Narod, {Steven A.}",
year = "1999",
month = "3",
doi = "10.1016/S0165-4608(98)00165-4",
language = "English",
volume = "109",
pages = "91--98",
journal = "Cancer Genetics and Cytogenetics",
issn = "0165-4608",
publisher = "Elsevier Inc.",
number = "2",

}

TY - JOUR

T1 - An update on DNA-based BRCA1/BRCA2 genetic counseling in hereditary breast cancer

AU - Lynch, Henry T.

AU - Watson, Patrice

AU - Tinley, Susan

AU - Snyder, Carrie

AU - Durham, Carolyn

AU - Lynch, Jane

AU - Kirnarsky, Yulia

AU - Serova, Olga

AU - Lenoir, Gilbert

AU - Lerman, Caryn

AU - Narod, Steven A.

PY - 1999/3

Y1 - 1999/3

N2 - The identification of BRCA1 and BRCA2 mutations has enabled physicians to identify persons at high risk for carcinoma of the breast and ovary in hereditary breast-ovarian cancer (HBOC) families. Many physicians have limited knowledge about the effective translation of these new discoveries into clinical practice settings. This problem is further confounded by the limited number of genetic counselors who have experience with cancer genetics. Genetic counseling about DNA test results was provided to 420 patients from 37 HBC/HBOC families. Descriptive data were collected and recorded about their responses to questions posed immediately before and after test results were disclosed. Findings disclosed a significant tendency of patients to overestimate rather than underestimate their risk (P <.001) prior to receiving results. The chief reason for declining to receive results was fear of insurance discrimination. The primary reason that patients sought test results was for their children. Most women reported that, if testing identified them as mutation carriers, they would consider lifetime surveillance and prophylactic surgery. Responses to DNA test results were varied and often unpredictable. Counseling by an appropriately educated and skilled professional is essential to assist people in making decisions regarding testing and health management.

AB - The identification of BRCA1 and BRCA2 mutations has enabled physicians to identify persons at high risk for carcinoma of the breast and ovary in hereditary breast-ovarian cancer (HBOC) families. Many physicians have limited knowledge about the effective translation of these new discoveries into clinical practice settings. This problem is further confounded by the limited number of genetic counselors who have experience with cancer genetics. Genetic counseling about DNA test results was provided to 420 patients from 37 HBC/HBOC families. Descriptive data were collected and recorded about their responses to questions posed immediately before and after test results were disclosed. Findings disclosed a significant tendency of patients to overestimate rather than underestimate their risk (P <.001) prior to receiving results. The chief reason for declining to receive results was fear of insurance discrimination. The primary reason that patients sought test results was for their children. Most women reported that, if testing identified them as mutation carriers, they would consider lifetime surveillance and prophylactic surgery. Responses to DNA test results were varied and often unpredictable. Counseling by an appropriately educated and skilled professional is essential to assist people in making decisions regarding testing and health management.

UR - http://www.scopus.com/inward/record.url?scp=0032988715&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032988715&partnerID=8YFLogxK

U2 - 10.1016/S0165-4608(98)00165-4

DO - 10.1016/S0165-4608(98)00165-4

M3 - Article

VL - 109

SP - 91

EP - 98

JO - Cancer Genetics and Cytogenetics

JF - Cancer Genetics and Cytogenetics

SN - 0165-4608

IS - 2

ER -