An update on Lynch syndrome

Henry T. Lynch, Thomas Smyrk

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Recent advances in hereditary nonpolyposis colorectal cancer (HNPCC) have been made based on the discovery early in this decade that germline mutations in genes responsible for repair of DNA mismatches formed the molecular basis for the syndrome. Several studies during the past year described the prevalence of germline mutations in those deemed at risk for HNPCC and helped define who should be tested for such mutations. Investigators are also beginning to make connections between genotype and phenotype; it appears that certain mutations are more likely than others to generate a broad spectrum of extracolonic tumors. Carcinogenetic mechanisms in HNPCC also received attention; evidence continues to accumulate that the critical somatic mutations driving malignant transformation in HNPCC (and in sporadic colorectal cancer with microsatellite instability) are different from the critical mutations seen in most colon cancers. Finally, several contributions dealt with the complicated question of how to manage germline carriers and affected individuals.

Original languageEnglish
Pages (from-to)349-356
Number of pages8
JournalCurrent Opinion in Oncology
Volume10
Issue number4
StatePublished - 1998

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Hereditary Nonpolyposis Colorectal Neoplasms
Mutation
Germ-Line Mutation
Microsatellite Instability
DNA Mismatch Repair
Colonic Neoplasms
Colorectal Neoplasms
Genotype
Research Personnel
Phenotype
Genes
Neoplasms

All Science Journal Classification (ASJC) codes

  • Cancer Research

Cite this

An update on Lynch syndrome. / Lynch, Henry T.; Smyrk, Thomas.

In: Current Opinion in Oncology, Vol. 10, No. 4, 1998, p. 349-356.

Research output: Contribution to journalArticle

Lynch, HT & Smyrk, T 1998, 'An update on Lynch syndrome', Current Opinion in Oncology, vol. 10, no. 4, pp. 349-356.
Lynch, Henry T. ; Smyrk, Thomas. / An update on Lynch syndrome. In: Current Opinion in Oncology. 1998 ; Vol. 10, No. 4. pp. 349-356.
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