Analysis of the mouse transcriptome for genes involved in the function of the nervous system

Stefano Gustincich, Serge Batalov, Kirk Beisel, Hidemasa Bono, Piero Carninci, Colin F. Fletcher, Sean Grimmond, Nobutaka Hirokawa, Erich D. Jarvis, Tim Jegla, Yuka Kawasawa, Julianna LeMieux, Harukata Miki, Elio Raviola, Rohan D. Teasdale, Naoko Tominaga, Ken Yagi, Andreas Zimmer, Takahiro Arakawa, Kazunori WakiJun Kawai, Yoshihide Hayashizaki, Yasushi Okazaki

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Abstract

We analyzed the mouse Representative Transcript and Protein Set for molecules involved in brain function. We found full-length cDNAs of many known brain genes and discovered new members of known brain gene families, including Family 3 G-protein coupled receptors, voltage-gated channels, and connexins. We also identified previously unknown candidates for secreted neuroactive molecules. The existence of a large number of unique brain ESTs suggests an additional molecular complexity that remains to be explored. A list of genes containing CAG stretches in the coding region represents a first step in the potential identification of candidates for hereditary neurological disorders.

Original languageEnglish
Pages (from-to)1395-1401
Number of pages7
JournalGenome Research
Volume13
Issue number6 B
DOIs
Publication statusPublished - Jun 1 2003

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All Science Journal Classification (ASJC) codes

  • Genetics

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Analysis of the mouse transcriptome for genes involved in the function of the nervous system. / Gustincich, Stefano; Batalov, Serge; Beisel, Kirk; Bono, Hidemasa; Carninci, Piero; Fletcher, Colin F.; Grimmond, Sean; Hirokawa, Nobutaka; Jarvis, Erich D.; Jegla, Tim; Kawasawa, Yuka; LeMieux, Julianna; Miki, Harukata; Raviola, Elio; Teasdale, Rohan D.; Tominaga, Naoko; Yagi, Ken; Zimmer, Andreas; Arakawa, Takahiro; Waki, Kazunori; Kawai, Jun; Hayashizaki, Yoshihide; Okazaki, Yasushi.

In: Genome Research, Vol. 13, No. 6 B, 01.06.2003, p. 1395-1401.

Research output: Contribution to journalArticle