Anti-interleukin-4 inhibits immunoglobulin E production in a murine model of atopic asthma

Chang Yi Zhou, I. Caroline Crocker, Gary Koenig, F. Antonio Romero, Robert G. Townley

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Abstract

Immunoglobulin E (IgE) plays an important role in allergy, acting as an initiating factor and being involved in its persistence and exacerbations. As interleukin-4 (IL-4) is critical in IgE synthesis, we propose that treatment of mice with monoclonal anti-IL-4 (11B11) prior to active sensitization with ovalbumin will inhibit IgE synthesis, therefore arresting the allergic process at an early stage. Mice treated with 11B11 and sensitized with saline or ovalbumin had significantly less serum IgE than their respective control groups which were treated with saline (p <0.05). This study suggests that anti-IL-4 may be a prophylactic agent in asthma and allergic disease.

Original languageEnglish (US)
Pages (from-to)195-201
Number of pages7
JournalJournal of Asthma
Volume34
Issue number3
DOIs
StatePublished - Jan 1 1997

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All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Immunology and Allergy
  • Pulmonary and Respiratory Medicine

Cite this

Zhou, C. Y., Caroline Crocker, I., Koenig, G., Antonio Romero, F., & Townley, R. G. (1997). Anti-interleukin-4 inhibits immunoglobulin E production in a murine model of atopic asthma. Journal of Asthma, 34(3), 195-201. https://doi.org/10.3109/02770909709068189