Antiallergic properties of the second-generation H1 antihistamines during the early and late reactions to antigen

Robert G. Townley

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Some of the second-generation H1 antihistamines reduce the bronchoconstrictor response after exercise and antigen challenge. For example, terfenadine causes a slight but significant increase in forced expiratory volume after 1 second. At doses of 120 and 240 mg, terfenadine has a protective effect against asthma induced by ultrasonic nebulized distilled water and cold air hyperventilation challenge. Certain other newer antihistamines, such as ketotifen, azelastine, and cetirizine, have additional antiallergy properties. These effects include inhibition of eosinophil, basophil, and neutrophil migration and platelet-activating factor-induced eosinophil accumulation in skin. The ability of cetirizine (and perhaps other antihistamines) to inhibit these responses at usual therapeutic doses may be useful in investigating the late allergic reaction.

Original languageEnglish
Pages (from-to)720-725
Number of pages6
JournalJournal of Allergy and Clinical Immunology
Volume90
Issue number4 PART 2
DOIs
StatePublished - 1992

Fingerprint

Non-Sedating Histamine H1 Antagonists
Cetirizine
Terfenadine
Anti-Allergic Agents
Histamine Antagonists
azelastine
Eosinophils
Bronchoconstrictor Agents
Ketotifen
Antigens
Hyperventilation
Basophils
Platelet Activating Factor
Forced Expiratory Volume
Ultrasonics
Hypersensitivity
Neutrophils
Asthma
Air
Skin

All Science Journal Classification (ASJC) codes

  • Immunology
  • Immunology and Allergy

Cite this

Antiallergic properties of the second-generation H1 antihistamines during the early and late reactions to antigen. / Townley, Robert G.

In: Journal of Allergy and Clinical Immunology, Vol. 90, No. 4 PART 2, 1992, p. 720-725.

Research output: Contribution to journalArticle

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