Antiepileptic Drugs

Antiepileptic Drug Mechanisms

Timothy Simeone, J. M. Rho

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Antiepileptic drugs (AEDs) represent the mainstay of epilepsy treatment, but we do not yet fully understand the mechanistic basis for their actions. A detailed knowledge of the molecular and cellular effects of AEDs is of paramount importance in our efforts to develop novel compounds with improved efficacy and safety profiles. There are three major classes of molecular targets on neuronal cell membranes believed to be relevant for the clinical actions of AEDs: (1) voltage-gated sodium and calcium channels; (2) γ-aminobutyric acid (GABAA) receptors; and (3) ionotropic glutamate receptors. AEDs exert their effects principally on one or more of these targets.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Basic Epilepsy Research
PublisherElsevier Inc.
Pages59-66
Number of pages8
ISBN (Print)9780123739612
DOIs
StatePublished - Jan 1 2009

Fingerprint

Anticonvulsants
Voltage-Gated Sodium Channels
Ionotropic Glutamate Receptors
GABA-A Receptors
Calcium Channels
Epilepsy
Cell Membrane
Safety

All Science Journal Classification (ASJC) codes

  • Medicine(all)
  • Neuroscience(all)

Cite this

Simeone, T., & Rho, J. M. (2009). Antiepileptic Drugs: Antiepileptic Drug Mechanisms. In Encyclopedia of Basic Epilepsy Research (pp. 59-66). Elsevier Inc.. https://doi.org/10.1016/B978-012373961-2.00160-0

Antiepileptic Drugs : Antiepileptic Drug Mechanisms. / Simeone, Timothy; Rho, J. M.

Encyclopedia of Basic Epilepsy Research. Elsevier Inc., 2009. p. 59-66.

Research output: Chapter in Book/Report/Conference proceedingChapter

Simeone, T & Rho, JM 2009, Antiepileptic Drugs: Antiepileptic Drug Mechanisms. in Encyclopedia of Basic Epilepsy Research. Elsevier Inc., pp. 59-66. https://doi.org/10.1016/B978-012373961-2.00160-0
Simeone T, Rho JM. Antiepileptic Drugs: Antiepileptic Drug Mechanisms. In Encyclopedia of Basic Epilepsy Research. Elsevier Inc. 2009. p. 59-66 https://doi.org/10.1016/B978-012373961-2.00160-0
Simeone, Timothy ; Rho, J. M. / Antiepileptic Drugs : Antiepileptic Drug Mechanisms. Encyclopedia of Basic Epilepsy Research. Elsevier Inc., 2009. pp. 59-66
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