Antillatoxin and kalkitoxin, ichthyotoxins from the tropical cyanobacterium Lyngbya majuscula, induce distinct temporal patterns of NMDA receptor-mediated neurotoxicity

F. W. Berman, W. H. Gerwick, Thomas F. Murray

Research output: Contribution to journalShort survey

64 Citations (Scopus)

Abstract

Curacin-A, antillatoxin and kalkitoxin, natural products from the marine cyanobacterium Lyngbya majuscula, were tested for neurotoxicity in primary cultures of rat cerebellar granule neurons. Curacin-A was non-toxic, whereas antillatoxin and kalkitoxin produced concentration-dependent cytotoxicity with LC50 values of 20.1±6.4 and 3.86±1.91 nM, respectively. Antillatoxin neurotoxicity was produced acutely, whereas kalkitoxin caused a delayed neurotoxic response. The cytotoxicity produced by both antillatoxin and kalkitoxin was prevented by the non-competitive NMDA receptor antagonists dextrorphan and MK-801. Copyright (C) 1999 Elsevier Science Ltd.

Original languageEnglish
Pages (from-to)1645-1648
Number of pages4
JournalToxicon
Volume37
Issue number11
DOIs
StatePublished - Nov 1999
Externally publishedYes

Fingerprint

Cyanobacteria
N-Methyl-D-Aspartate Receptors
Cytotoxicity
Dextrorphan
Dizocilpine Maleate
Biological Products
Neurons
Rats
antillatoxin
kalkitoxin
curacin A

All Science Journal Classification (ASJC) codes

  • Toxicology

Cite this

Antillatoxin and kalkitoxin, ichthyotoxins from the tropical cyanobacterium Lyngbya majuscula, induce distinct temporal patterns of NMDA receptor-mediated neurotoxicity. / Berman, F. W.; Gerwick, W. H.; Murray, Thomas F.

In: Toxicon, Vol. 37, No. 11, 11.1999, p. 1645-1648.

Research output: Contribution to journalShort survey

@article{2f735d1d23da4113884483cd91d78c51,
title = "Antillatoxin and kalkitoxin, ichthyotoxins from the tropical cyanobacterium Lyngbya majuscula, induce distinct temporal patterns of NMDA receptor-mediated neurotoxicity",
abstract = "Curacin-A, antillatoxin and kalkitoxin, natural products from the marine cyanobacterium Lyngbya majuscula, were tested for neurotoxicity in primary cultures of rat cerebellar granule neurons. Curacin-A was non-toxic, whereas antillatoxin and kalkitoxin produced concentration-dependent cytotoxicity with LC50 values of 20.1±6.4 and 3.86±1.91 nM, respectively. Antillatoxin neurotoxicity was produced acutely, whereas kalkitoxin caused a delayed neurotoxic response. The cytotoxicity produced by both antillatoxin and kalkitoxin was prevented by the non-competitive NMDA receptor antagonists dextrorphan and MK-801. Copyright (C) 1999 Elsevier Science Ltd.",
author = "Berman, {F. W.} and Gerwick, {W. H.} and Murray, {Thomas F.}",
year = "1999",
month = "11",
doi = "10.1016/S0041-0101(99)00108-7",
language = "English",
volume = "37",
pages = "1645--1648",
journal = "Toxicon",
issn = "0041-0101",
publisher = "Elsevier Limited",
number = "11",

}

TY - JOUR

T1 - Antillatoxin and kalkitoxin, ichthyotoxins from the tropical cyanobacterium Lyngbya majuscula, induce distinct temporal patterns of NMDA receptor-mediated neurotoxicity

AU - Berman, F. W.

AU - Gerwick, W. H.

AU - Murray, Thomas F.

PY - 1999/11

Y1 - 1999/11

N2 - Curacin-A, antillatoxin and kalkitoxin, natural products from the marine cyanobacterium Lyngbya majuscula, were tested for neurotoxicity in primary cultures of rat cerebellar granule neurons. Curacin-A was non-toxic, whereas antillatoxin and kalkitoxin produced concentration-dependent cytotoxicity with LC50 values of 20.1±6.4 and 3.86±1.91 nM, respectively. Antillatoxin neurotoxicity was produced acutely, whereas kalkitoxin caused a delayed neurotoxic response. The cytotoxicity produced by both antillatoxin and kalkitoxin was prevented by the non-competitive NMDA receptor antagonists dextrorphan and MK-801. Copyright (C) 1999 Elsevier Science Ltd.

AB - Curacin-A, antillatoxin and kalkitoxin, natural products from the marine cyanobacterium Lyngbya majuscula, were tested for neurotoxicity in primary cultures of rat cerebellar granule neurons. Curacin-A was non-toxic, whereas antillatoxin and kalkitoxin produced concentration-dependent cytotoxicity with LC50 values of 20.1±6.4 and 3.86±1.91 nM, respectively. Antillatoxin neurotoxicity was produced acutely, whereas kalkitoxin caused a delayed neurotoxic response. The cytotoxicity produced by both antillatoxin and kalkitoxin was prevented by the non-competitive NMDA receptor antagonists dextrorphan and MK-801. Copyright (C) 1999 Elsevier Science Ltd.

UR - http://www.scopus.com/inward/record.url?scp=0033231630&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033231630&partnerID=8YFLogxK

U2 - 10.1016/S0041-0101(99)00108-7

DO - 10.1016/S0041-0101(99)00108-7

M3 - Short survey

VL - 37

SP - 1645

EP - 1648

JO - Toxicon

JF - Toxicon

SN - 0041-0101

IS - 11

ER -