Abstract
Curacin-A, antillatoxin and kalkitoxin, natural products from the marine cyanobacterium Lyngbya majuscula, were tested for neurotoxicity in primary cultures of rat cerebellar granule neurons. Curacin-A was non-toxic, whereas antillatoxin and kalkitoxin produced concentration-dependent cytotoxicity with LC50 values of 20.1±6.4 and 3.86±1.91 nM, respectively. Antillatoxin neurotoxicity was produced acutely, whereas kalkitoxin caused a delayed neurotoxic response. The cytotoxicity produced by both antillatoxin and kalkitoxin was prevented by the non-competitive NMDA receptor antagonists dextrorphan and MK-801. Copyright (C) 1999 Elsevier Science Ltd.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1645-1648 |
| Number of pages | 4 |
| Journal | Toxicon |
| Volume | 37 |
| Issue number | 11 |
| DOIs | |
| State | Published - Nov 1999 |
| Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Toxicology
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Berman, F. W., Gerwick, W. H., & Murray, T. F. (1999). Antillatoxin and kalkitoxin, ichthyotoxins from the tropical cyanobacterium Lyngbya majuscula, induce distinct temporal patterns of NMDA receptor-mediated neurotoxicity. Toxicon, 37(11), 1645-1648. https://doi.org/10.1016/S0041-0101(99)00108-7