Abstract
Curacin-A, antillatoxin and kalkitoxin, natural products from the marine cyanobacterium Lyngbya majuscula, were tested for neurotoxicity in primary cultures of rat cerebellar granule neurons. Curacin-A was non-toxic, whereas antillatoxin and kalkitoxin produced concentration-dependent cytotoxicity with LC50 values of 20.1±6.4 and 3.86±1.91 nM, respectively. Antillatoxin neurotoxicity was produced acutely, whereas kalkitoxin caused a delayed neurotoxic response. The cytotoxicity produced by both antillatoxin and kalkitoxin was prevented by the non-competitive NMDA receptor antagonists dextrorphan and MK-801. Copyright (C) 1999 Elsevier Science Ltd.
Original language | English (US) |
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Pages (from-to) | 1645-1648 |
Number of pages | 4 |
Journal | Toxicon |
Volume | 37 |
Issue number | 11 |
DOIs | |
State | Published - Nov 1999 |
Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Toxicology