Antillatoxin and kalkitoxin, ichthyotoxins from the tropical cyanobacterium Lyngbya majuscula, induce distinct temporal patterns of NMDA receptor-mediated neurotoxicity

F. W. Berman; W. H. Gerwick; T. F. Murray

doi:10.1016/S0041-0101(99)00108-7

Antillatoxin and kalkitoxin, ichthyotoxins from the tropical cyanobacterium Lyngbya majuscula, induce distinct temporal patterns of NMDA receptor-mediated neurotoxicity

F. W. Berman, W. H. Gerwick, T. F. Murray

Research output: Contribution to journal › Article › peer-review

78 Scopus citations

Abstract

Curacin-A, antillatoxin and kalkitoxin, natural products from the marine cyanobacterium Lyngbya majuscula, were tested for neurotoxicity in primary cultures of rat cerebellar granule neurons. Curacin-A was non-toxic, whereas antillatoxin and kalkitoxin produced concentration-dependent cytotoxicity with LC₅₀ values of 20.1±6.4 and 3.86±1.91 nM, respectively. Antillatoxin neurotoxicity was produced acutely, whereas kalkitoxin caused a delayed neurotoxic response. The cytotoxicity produced by both antillatoxin and kalkitoxin was prevented by the non-competitive NMDA receptor antagonists dextrorphan and MK-801. Copyright (C) 1999 Elsevier Science Ltd.

Original language	English (US)
Pages (from-to)	1645-1648
Number of pages	4
Journal	Toxicon
Volume	37
Issue number	11
DOIs	https://doi.org/10.1016/S0041-0101(99)00108-7
State	Published - Nov 1999
Externally published	Yes

All Science Journal Classification (ASJC) codes

Toxicology

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10.1016/S0041-0101(99)00108-7

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@article{2f735d1d23da4113884483cd91d78c51,

title = "Antillatoxin and kalkitoxin, ichthyotoxins from the tropical cyanobacterium Lyngbya majuscula, induce distinct temporal patterns of NMDA receptor-mediated neurotoxicity",

abstract = "Curacin-A, antillatoxin and kalkitoxin, natural products from the marine cyanobacterium Lyngbya majuscula, were tested for neurotoxicity in primary cultures of rat cerebellar granule neurons. Curacin-A was non-toxic, whereas antillatoxin and kalkitoxin produced concentration-dependent cytotoxicity with LC50 values of 20.1±6.4 and 3.86±1.91 nM, respectively. Antillatoxin neurotoxicity was produced acutely, whereas kalkitoxin caused a delayed neurotoxic response. The cytotoxicity produced by both antillatoxin and kalkitoxin was prevented by the non-competitive NMDA receptor antagonists dextrorphan and MK-801. Copyright (C) 1999 Elsevier Science Ltd.",

author = "Berman, {F. W.} and Gerwick, {W. H.} and Murray, {T. F.}",

note = "Funding Information: This work was supported in part through a pilot project grant from the Marine/Freshwater Biomedical Sciences Center of Oregon State University (ES03850). The authors also thank Dr. Paul Franklin for making us aware of his unpublished data regarding the cytotoxicity of antillatoxin. ",

year = "1999",

month = nov,

doi = "10.1016/S0041-0101(99)00108-7",

language = "English (US)",

volume = "37",

pages = "1645--1648",

journal = "Toxicon",

issn = "0041-0101",

publisher = "Elsevier Limited",

number = "11",

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TY - JOUR

T1 - Antillatoxin and kalkitoxin, ichthyotoxins from the tropical cyanobacterium Lyngbya majuscula, induce distinct temporal patterns of NMDA receptor-mediated neurotoxicity

AU - Berman, F. W.

AU - Gerwick, W. H.

AU - Murray, T. F.

N1 - Funding Information: This work was supported in part through a pilot project grant from the Marine/Freshwater Biomedical Sciences Center of Oregon State University (ES03850). The authors also thank Dr. Paul Franklin for making us aware of his unpublished data regarding the cytotoxicity of antillatoxin.

PY - 1999/11

Y1 - 1999/11

N2 - Curacin-A, antillatoxin and kalkitoxin, natural products from the marine cyanobacterium Lyngbya majuscula, were tested for neurotoxicity in primary cultures of rat cerebellar granule neurons. Curacin-A was non-toxic, whereas antillatoxin and kalkitoxin produced concentration-dependent cytotoxicity with LC50 values of 20.1±6.4 and 3.86±1.91 nM, respectively. Antillatoxin neurotoxicity was produced acutely, whereas kalkitoxin caused a delayed neurotoxic response. The cytotoxicity produced by both antillatoxin and kalkitoxin was prevented by the non-competitive NMDA receptor antagonists dextrorphan and MK-801. Copyright (C) 1999 Elsevier Science Ltd.

AB - Curacin-A, antillatoxin and kalkitoxin, natural products from the marine cyanobacterium Lyngbya majuscula, were tested for neurotoxicity in primary cultures of rat cerebellar granule neurons. Curacin-A was non-toxic, whereas antillatoxin and kalkitoxin produced concentration-dependent cytotoxicity with LC50 values of 20.1±6.4 and 3.86±1.91 nM, respectively. Antillatoxin neurotoxicity was produced acutely, whereas kalkitoxin caused a delayed neurotoxic response. The cytotoxicity produced by both antillatoxin and kalkitoxin was prevented by the non-competitive NMDA receptor antagonists dextrorphan and MK-801. Copyright (C) 1999 Elsevier Science Ltd.

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U2 - 10.1016/S0041-0101(99)00108-7

DO - 10.1016/S0041-0101(99)00108-7

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AN - SCOPUS:0033231630

VL - 37

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JO - Toxicon

JF - Toxicon

SN - 0041-0101

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ER -

Antillatoxin and kalkitoxin, ichthyotoxins from the tropical cyanobacterium Lyngbya majuscula, induce distinct temporal patterns of NMDA receptor-mediated neurotoxicity

Abstract

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