Antimicrobial interference with bacterial mechanisms of pathogenicity: Effect of sub-MIC azithromycin on gonococcal piliation and attachment to human epithelial cells

G. L. Gorby, Z. A. McGee

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

The effects of subinhibitory concentrations of azithromycin (CP-62,993) on the piliation and attachment properties of Neisseria gonorrhoeae were examined. Subinhibitory concentrations of azithromycin significantly reduced the percentage of gonococci that expressed assembled pili on their surfaces by decreasing pilin subunit synthesis and substantially decreased gonococcal adherence to human mucosal cells.

Original languageEnglish (US)
Pages (from-to)2445-2448
Number of pages4
JournalAntimicrobial agents and chemotherapy
Volume34
Issue number12
DOIs
StatePublished - 1990

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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