Antimicrobial interference with bacterial mechanisms of pathogenicity

Effect of sub-MIC azithromycin on gonococcal piliation and attachment to human epithelial cells

Gary L. Gorby, Z. A. McGee

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

The effects of subinhibitory concentrations of azithromycin (CP-62,993) on the piliation and attachment properties of Neisseria gonorrhoeae were examined. Subinhibitory concentrations of azithromycin significantly reduced the percentage of gonococci that expressed assembled pili on their surfaces by decreasing pilin subunit synthesis and substantially decreased gonococcal adherence to human mucosal cells.

Original languageEnglish
Pages (from-to)2445-2448
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
Volume34
Issue number12
StatePublished - 1990

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Antibiosis
Azithromycin
Neisseria gonorrhoeae
Virulence
Epithelial Cells
Fimbriae Proteins

All Science Journal Classification (ASJC) codes

  • Pharmacology (medical)

Cite this

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abstract = "The effects of subinhibitory concentrations of azithromycin (CP-62,993) on the piliation and attachment properties of Neisseria gonorrhoeae were examined. Subinhibitory concentrations of azithromycin significantly reduced the percentage of gonococci that expressed assembled pili on their surfaces by decreasing pilin subunit synthesis and substantially decreased gonococcal adherence to human mucosal cells.",
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AB - The effects of subinhibitory concentrations of azithromycin (CP-62,993) on the piliation and attachment properties of Neisseria gonorrhoeae were examined. Subinhibitory concentrations of azithromycin significantly reduced the percentage of gonococci that expressed assembled pili on their surfaces by decreasing pilin subunit synthesis and substantially decreased gonococcal adherence to human mucosal cells.

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