Antimicrobial peptides of the brevinin-2 family isolated from gastric tissue of the frog, Rana esculenta

Yuqi Wang, Floyd C. Knoop, Isabelle Remy-Jouet, Catherine Delarue, Hubert Vaudry, J. Michael Conlon

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Four structurally related peptides with potent growth-inhibitory activity towards Escherichia coli were isolated from an extract of the stomach of the European green frog Rana esculenta, and were identified as members of the brevinin-2 family. Two peptides, termed brevinin-2Eg (GIMDTLKNLA10 KTAGKGALQS20 LLNHASCK LS30GQC) and brevinin-2Eh (GIMDTLKNLA10 KTAGKGALQS20 LLNHASCKL S30 KQC) have not been described previously. One peptide is identical to brevinin-2Ec, previously isolated from R. esculenta skin secretions, and one peptide is identical to brevinin-2Ef whose structure has been deduced from a cloned cDNA prepared from a R. esculenta skin cDNA library. The data demonstrate that certain peptides of the brevinin-2 family, like the magainins in the toad, Xenopus laevis, may play an important role in protecting the gastrointestinal tract of Ranid frogs against microbial invasion.

Original languageEnglish (US)
Pages (from-to)600-603
Number of pages4
JournalBiochemical and Biophysical Research Communications
Volume253
Issue number3
DOIs
StatePublished - Dec 30 1998

Fingerprint

Rana esculenta
Anura
Stomach
Tissue
Peptides
Skin
Rana clamitans
Magainins
Xenopus laevis
Gene Library
Escherichia coli
Gastrointestinal Tract
Complementary DNA
Growth

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

Antimicrobial peptides of the brevinin-2 family isolated from gastric tissue of the frog, Rana esculenta. / Wang, Yuqi; Knoop, Floyd C.; Remy-Jouet, Isabelle; Delarue, Catherine; Vaudry, Hubert; Conlon, J. Michael.

In: Biochemical and Biophysical Research Communications, Vol. 253, No. 3, 30.12.1998, p. 600-603.

Research output: Contribution to journalArticle

Wang, Yuqi ; Knoop, Floyd C. ; Remy-Jouet, Isabelle ; Delarue, Catherine ; Vaudry, Hubert ; Conlon, J. Michael. / Antimicrobial peptides of the brevinin-2 family isolated from gastric tissue of the frog, Rana esculenta. In: Biochemical and Biophysical Research Communications. 1998 ; Vol. 253, No. 3. pp. 600-603.
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AU - Vaudry, Hubert

AU - Conlon, J. Michael

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