Antimicrobial peptides of the brevinin-2 family isolated from gastric tissue of the frog, Rana esculenta

Yuqi Wang, Floyd C. Knoop, Isabelle Remy-Jouet, Catherine Delarue, Hubert Vaudry, J. Michael Conlon

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17 Scopus citations

Abstract

Four structurally related peptides with potent growth-inhibitory activity towards Escherichia coli were isolated from an extract of the stomach of the European green frog Rana esculenta, and were identified as members of the brevinin-2 family. Two peptides, termed brevinin-2Eg (GIMDTLKNLA10 KTAGKGALQS20 LLNHASCK LS30GQC) and brevinin-2Eh (GIMDTLKNLA10 KTAGKGALQS20 LLNHASCKL S30 KQC) have not been described previously. One peptide is identical to brevinin-2Ec, previously isolated from R. esculenta skin secretions, and one peptide is identical to brevinin-2Ef whose structure has been deduced from a cloned cDNA prepared from a R. esculenta skin cDNA library. The data demonstrate that certain peptides of the brevinin-2 family, like the magainins in the toad, Xenopus laevis, may play an important role in protecting the gastrointestinal tract of Ranid frogs against microbial invasion.

Original languageEnglish (US)
Pages (from-to)600-603
Number of pages4
JournalBiochemical and Biophysical Research Communications
Volume253
Issue number3
DOIs
StatePublished - Dec 30 1998

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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