Antipsychotic-like profile of CIQ isomers in animal models of schizophrenia

Pushparaj Gawai, Rohit Upadhyay, Sukanya G. Gakare, Lopmudra Sarode, Shashank M. Dravid, Rajesh R. Ugale

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Earlier, we have shown the efficacy of racemic (±) CIQ, a positive allosteric modulator of GluN2C/2D receptor against MK-801 induced impairment of prepulse inhibition as well as working memory. The present study investigated the antipsychotic-like profile of different CIQ (±, +,-) isomers against schizophrenia-like symptoms in series of behavioural animal models like apomorphine climbing, social isolation behaviour and NMDA receptor antagonist MK-801 induced cognitive deficits. Further, we also tested CIQ (±, +,-) isomers in neurodevelopmental model against MK-801induced deficits using open field test, Y-maze test and novel object recognition test. CIQ (±, +,-) isomers decreased climbing behaviour, increased social interaction and improved the MK-801 induced deficits in working memory in Y-maze. Further, CIQ (±, +) but not CIQ (-) improved the recognition memory in novel object recognition test as well as reduced hyperlocomotion and stereotyped behaviour. We conclude that CIQ (±, +) but not CIQ (-) exhibit the significant antipsychotic-like profile.

Original languageEnglish (US)
Pages (from-to)524-534
Number of pages11
JournalBehavioural Pharmacology
Volume31
Issue number6
DOIs
StatePublished - Sep 1 2020

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Psychiatry and Mental health

Fingerprint Dive into the research topics of 'Antipsychotic-like profile of CIQ isomers in animal models of schizophrenia'. Together they form a unique fingerprint.

Cite this