Antiviral therapy for chronic hepatitis C in 2014

Manogna Nookathota, Sandeep Mukherjee

Research output: Contribution to journalReview article

5 Scopus citations

Abstract

An all-oral therapy for treating hepatitis C (HCV) is now available for the most common genotypes although interferon-based therapy is still recommended for interferon-eligible patients with HCV genotype 1. For most patients, a prior history of treatment or presence of cirrhosis does not appear to significantly impact eradication rates with direct acting antivirals (DAA). The promising results from the numerous clinical trials of DAA's for HCV together with their tolerability represent a tremendous advance in our management of this disease, particularly as treatment is often well-tolerated, associated with few side effects and significantly shortened in duration. We will review several of the peer-reviewed landmark studies of DAA's for the treatment HCV and conclude with an expert commentary and five year view.

Original languageEnglish
Pages (from-to)499-505
Number of pages7
JournalExpert Review of Clinical Pharmacology
Volume7
Issue number4
DOIs
Publication statusPublished - 2014

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All Science Journal Classification (ASJC) codes

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Medicine(all)

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