Aortic baroreceptor characteristics in dogs with chronic high output failure

M. J. Niebauer, M. J. Holmberg, I. H. Zucker

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


It has been shown that the arterial baroreflex is depressed in heart failure. The role of alterations in afferent discharge as a possible mechanism for this depression has not been investigated previously. Single unit aortic baroreceptor activity was recorded from six normal dogs and from nine dogs, each with a chronic aorto-caval fistula (AVF). At the time of the acute experiment, mean arterial blood pressure (MABP) was not significantly different in the two groups of dogs; however, pulse pressure was significantly higher in the AVF dogs (45.7±2.4 mm Hg vs, 24.4±2.0 mm Hg; p

Original languageEnglish (US)
Pages (from-to)111-122
Number of pages12
JournalBasic Research in Cardiology
Issue number2
StatePublished - Mar 1 1986
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)


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