Aortic baroreceptor characteristics in dogs with chronic high output failure

M. J. Niebauer, Mark Jeffrey Holmberg, I. H. Zucker

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Abstract

It has been shown that the arterial baroreflex is depressed in heart failure. The role of alterations in afferent discharge as a possible mechanism for this depression has not been investigated previously. Single unit aortic baroreceptor activity was recorded from six normal dogs and from nine dogs, each with a chronic aorto-caval fistula (AVF). At the time of the acute experiment, mean arterial blood pressure (MABP) was not significantly different in the two groups of dogs; however, pulse pressure was significantly higher in the AVF dogs (45.7±2.4 mm Hg vs, 24.4±2.0 mm Hg; p

Original languageEnglish
Pages (from-to)111-122
Number of pages12
JournalBasic Research in Cardiology
Volume81
Issue number2
DOIs
Publication statusPublished - Mar 1986
Externally publishedYes

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All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

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