Abstract
Apoptosis, or controlled cell death, is a normal part of cellular lifespan. Cell death of cochlear hair cells causes deafness; an apoptotic process that is not well understood. Worldwide, 1.3 billion humans suffer some form of hearing loss, while 360 million suffer debilitating hearing loss as a direct result of the absence of these cochlear hair cells (Worldwide Hearing, 2014). Much is known about apoptosis in other systems and in other cell types thanks to studies done since the mid-20th century. Here we review current literature on apoptosis in general, and causes of deafness and cochlear hair cells loss as a result of apoptosis. The family of B-cell lymphoma (Bcl) proteins are among the most studied and characterized. We will review current literature on the Bcl2 and Bcl6 protein interactions in relation to apoptosis and their possible roles in vulnerability and survival of cochlear hair cells.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 151-164 |
| Number of pages | 14 |
| Journal | Journal of Otology |
| Volume | 12 |
| Issue number | 4 |
| DOIs | |
| State | Published - Dec 1 2017 |
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All Science Journal Classification (ASJC) codes
- Otorhinolaryngology
Cite this
Apoptosis in inner ear sensory hair cells. / Morrill, Seth; He, David Z.
In: Journal of Otology, Vol. 12, No. 4, 01.12.2017, p. 151-164.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Apoptosis in inner ear sensory hair cells
AU - Morrill, Seth
AU - He, David Z.
PY - 2017/12/1
Y1 - 2017/12/1
N2 - Apoptosis, or controlled cell death, is a normal part of cellular lifespan. Cell death of cochlear hair cells causes deafness; an apoptotic process that is not well understood. Worldwide, 1.3 billion humans suffer some form of hearing loss, while 360 million suffer debilitating hearing loss as a direct result of the absence of these cochlear hair cells (Worldwide Hearing, 2014). Much is known about apoptosis in other systems and in other cell types thanks to studies done since the mid-20th century. Here we review current literature on apoptosis in general, and causes of deafness and cochlear hair cells loss as a result of apoptosis. The family of B-cell lymphoma (Bcl) proteins are among the most studied and characterized. We will review current literature on the Bcl2 and Bcl6 protein interactions in relation to apoptosis and their possible roles in vulnerability and survival of cochlear hair cells.
AB - Apoptosis, or controlled cell death, is a normal part of cellular lifespan. Cell death of cochlear hair cells causes deafness; an apoptotic process that is not well understood. Worldwide, 1.3 billion humans suffer some form of hearing loss, while 360 million suffer debilitating hearing loss as a direct result of the absence of these cochlear hair cells (Worldwide Hearing, 2014). Much is known about apoptosis in other systems and in other cell types thanks to studies done since the mid-20th century. Here we review current literature on apoptosis in general, and causes of deafness and cochlear hair cells loss as a result of apoptosis. The family of B-cell lymphoma (Bcl) proteins are among the most studied and characterized. We will review current literature on the Bcl2 and Bcl6 protein interactions in relation to apoptosis and their possible roles in vulnerability and survival of cochlear hair cells.
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UR - http://www.scopus.com/inward/citedby.url?scp=85047004763&partnerID=8YFLogxK
U2 - 10.1016/j.joto.2017.08.001
DO - 10.1016/j.joto.2017.08.001
M3 - Review article
VL - 12
SP - 151
EP - 164
JO - Journal of Otology
JF - Journal of Otology
SN - 1672-2930
IS - 4
ER -