Abstract
Aripirazole is a novel antipsychotic that functions as a partial agonist at the dopamine D2 receptor and, thus, might theoretically worsen psychosis. We report a series of four clinical cases of exacerbation of psychosis related to initiation of aripiprazole therapy. Cases 1 and 2 demonstrated the worsening of psychosis following initiation of aripiprazole (15-30 mg daily) while tapering off the previous atypical antipsychotic. Cases 3 and 4 demonstrated worsening of psychosis following the addition of aripiprazole (15-30 mg daily) to an atypical antipsychotic. In two out of the four cases, discontinuation of arpiprazole resulted In improvement of psychotic symptoms. Although the cases presented are suggestive of a relationship between initiation of aripiprazole therapy and worsening of psychosis, further research is needed to clarify any potential association.
Original language | English (US) |
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Pages (from-to) | 45-48 |
Number of pages | 4 |
Journal | International Clinical Psychopharmacology |
Volume | 19 |
Issue number | 1 |
DOIs | |
State | Published - Jan 1 2004 |
All Science Journal Classification (ASJC) codes
- Psychiatry and Mental health
- Pharmacology (medical)